T-cell receptor

spinqualitylabelsall models T-cell receptorα chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) 2xna. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function T-cell receptors (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have γ+δ subumits. TCR NKT reside in Natural Killer T-cells. T-cell receptor α chain, β chain complex with enterotoxin and Na+ ion (2xna). For more details see SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex. Relevance Genes encoding antigen-specific receptors into T cells can redirect their functional activity against targets including virally infected or cancer cells. This technique is currently developed by several biotechnology companies and implemented in therapy. 3D structures of T-cell receptor T-cell receptor 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky