Tailspike protein

spinqualitylabelsall models Glycosylated tailspike protein from bacteriophage P222 complex with octasaccharide (PDB code 3th0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The tailspike protein (TSP) of bacteriophage is a trimeric protein which serves as the receptor-binding protein of the bacteriophage to its bacterial host. O-antigen polysaccharides found on the outer surface of bacteria are the natural substrates for TSP. Relevance Bacteriophage research is becoming important due to the problem of antibiotics resistance. TSP binding to pathogenic bacteria can be used for their detection. Structural highlights The C-terminal domain (CTD) (residues 109-end) of TSP is responsible for the attachment of the tailspike protein to the O-antigen moiety on bacterial cell surface. The 3D structure of an octasaccharide bound to CTP of TSP shows numerous hydrophobic interactions as well as defined water molecules forming hydrogen bonds to the antigen. 3D structures of tailspike protein Tailspike protein 3D structures

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