Tetracycline repressor protein

spinqualitylabelsall models Tetracycline repressor protein complex with tetracycline and Mg+2 ion (green), 2trt Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Tetracycline repressor protein (TetR) causes the resistance of bacterial cells to antibiotics like tetracycline (TC). TetR binds TC with higher affinity than the ribosome thus preventing TC from binding there and inhibiting the pathogenic bacteria protein synthesis. HTH-type TetR is a prokaryotic TetR which contains a DNA-binding Helix-Turn-Helix domain of ca. 60 residues. Structural highlights TetR binds DNA with a helix-turn-helix motif. The inhibitor TC binds in the active site to several TetR side chains and to an octahedraly-coordinated Mg+2 ion . Water molecules are shown as red spheres. Mg coordination site. 3D Structures of tetracycline repressor protein Tetracycline repressor protein 3D structures

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