Thiamin phosphate synthase

spinqualitylabelsall models Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code 2tps) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thiamin phosphate synthase (TPS) or thiamin-phosphate pyrophosphorylase catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate. Relevance Thiamin is an essential component of human diet. Thiamin deficiency is associated with neurodegenerative diseases, delirium, obesity and results in beriberi and in the alcoholic brain disease Korsakoff's syndrome. TPS is involved in thiamin biosynthesis. Structural highlights The active site pocket of TPS is formed by three loop regions. TPS reaction products thiamin phosphate and pyrophosphate interact with various residues of the protein as well as with each other. Active site pocket. Mg coordination site. Water molecules are shown as red spheres. Pyrophosphate binding site. Thiamin phosphate binding site. Whole active site. 3D structures of thiamin phosphate synthase Updated on 18-August-2024 1g4e, 3o16 - BsTPS (mutant) - Bacillus subtilis 1g4p - BsTPS (mutant) + Thz-P 1g67, 1g69, 1g6c - BsTPS (mutant) + Thz-P + PPi 1g4t - BsTPS + thiamine phosphate derivative 1g4s - BsTPS (mutant) + thiamine phosphate derivative 2tps - BsTPS + thiamine phosphate + PPi 3o15 - BsTPS + thiazole phosphate derivative + PPi 3o63 - TPS + Pi - Mycobacterium tuberculosis 1xi3 - TPS - Pyrococcus furiosus 3ceu - TPS - Bacterioides thetaiotamicron

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