Thioredoxin Reductase

spinqualitylabelsall models Human Thioredoxin reductase dimer (cyan, green) complex with thioredoxin (yellow, pink), glycerol and FAD (PDB entry 3qfa) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thioredoxin Reductase or glutaredoxin domain-containing protein (TrxR) is an enzyme which reduces thioredoxin using NADPH. TrxR-1 is cystolic while TrxR-2 is mitochondrial. TrxR-3 is highly expressed in testis. For more details see: User:Sarah Abdalla/Thioredoxin Reductase Glucocorticoids Steroid Hormones and their receptors Disease Mutations in TrxR-2 are associated with familial glucocorticoid deficiency. Structural highlights TrxR and Trx form an intramolecular Cys-Cys bond. FAD binding site. Water molecules are shown as red spheres. 3D Structures of Thioredoxin Reductase Thioredoxin reductase 3D structures

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