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Function
Thrombospondin (TSP) are glycoproteins released in response to thrombin stimulation. TSP is a transient component of extracellular matrix in developing tissues[1].
Relevance
TSP-1 and TSP-2 are potent inhibitors of angiogenesis and thus are studied in cancer treatments[2].
Disease
TSP-2 mutation is associated with coronary artery disease[3].
Structural highlights
The N-terminal of TSP-1 mediates its interaction with integrins during cell adhesion, with lipoproteinreceptor-related protein during uptake and clearance and with fibrinogen during platelet aggregation. The arginine and lysine side chains of the N-terminal interact with the heparin sulfate groups[4].
- ↑ Adams JC. Thrombospondin-1. Int J Biochem Cell Biol. 1997 Jun;29(6):861-5. PMID:9304800
- ↑ Lawler PR, Lawler J. Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med. 2012 May;2(5):a006627. doi:, 10.1101/cshperspect.a006627. PMID:22553494 doi:https://dx.doi.org/10.1101/cshperspect.a006627
- ↑ Carlson CB, Liu Y, Keck JL, Mosher DF. Influences of the N700S thrombospondin-1 polymorphism on protein structure and stability. J Biol Chem. 2008 Jul 18;283(29):20069-76. Epub 2008 May 22. PMID:18499674 doi:10.1074/jbc.M800223200
- ↑ Tan K, Duquette M, Liu JH, Zhang R, Joachimiak A, Wang JH, Lawler J. The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin. Structure. 2006 Jan;14(1):33-42. PMID:16407063 doi:10.1016/j.str.2005.09.017
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3D structures of thrombospondin
Updated on 19-August-2024
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- Thrombospondin-1
- 1ux6 – hTSP-1 C-terminal (mutant) 831-1170 + Ca - human
- 1lsl, 3r6b – hTSP-1 repeats 2-3 434-547
- 1z78, 2erf, 2es3, 2ouh, 2ouj – hTSP-1 N-terminal 25-233
- 7yyk – hTSP-1 378-547
- 1za4 – hTSP-1 N-terminal + heparin
- Thrombospondin-2
- 1yo8 – hTSP-2 C-terminal
- 2rhp – hTSP-2 signature domain (mutant)
References
