Thymidylate kinase

spinqualitylabelsall models Human thymidylate kinase complex with HIV prodrug AZTP, ADP and Mg+2 ion (green) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. For more details see Student Project 8 for UMass Chemistry 423 Spring 2015. Relevance The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite. Inhibitors of TMK are used as antibacterial agents. Structural highlights The active site of TMK contains HIV prodrug azido-thymidine, ADP and Mg+2 ion. Azido-thymidine binding site. Water molecules are shown as red spheres. Mg coordination site. ATM binding site. Whole binding site. 3D Structures of thymidylate kinase Thymidylate kinase 3D structures

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