Transcriptional activator 3D structures

3D Structures of transcriptional activator

Updated on 29-March-2026 - For a general description of the protein see Transcriptional activator

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• Gcn4 TA See Gcn4
• Gcn5 TA
  • 1e6i – yTA brododomain + histone H4 peptide - yeast
  • 1ygh – yTA histone acetyltransferase domain
• C-Myb TA; domains – DBD ; DBD repeat 1 38-89; repeat 2 90-141; repeat 3 142-193; transcription activation 291-315
  • 1mse, 1msf – mTA DBD 90-193 + DNA – NMR - mouse
  • 1mbe, 1mbf – mTA DBD repeat 1 + DNA - NMR
  • 1mbg, 1mbh – mTA DBD repeat 2 + DNA - NMR
  • 1mbj, 1mbk – mTA DBD repeat 3 + DNA - NMR
  • 1h88 – mTA DBD + DNA + CCAAT/enhancer binding protein β
  • 1h89 – mTA DBD + DNA + CAAT/enhancer binding protein β
  • 1guu – mTA DBD repeat 1
  • 1gv2 – mTA DBD repeat 2,3
  • 1gv5 – mTA DBD repeat 2
  • 1gvd – mTA DBD repeat 2 (mutant)
  • 1idy, 1idz – mTA DBD repeat 3 (mutant) - NMR
  • 1sb0, 2agh – mTA transcription activation domain + CREB-binding protein - NMR
  • 6dmx, 6dnq – mTA transcription activation domain + CREB-binding protein p3ptide + Bzip factor
• Psp operon TA
  • 2bjw – EcTA AAA domain – Escherichia coli
  • 4qnr – EcTA AAA domain (mutant) + ATP
  • 4qos – EcTA AAA domain (mutant) + ADP
  • 2c98 – EcTA AAA domain + ADP
  • 2c99 – EcTA AAA domain + AMPPNP
  • 2vii – EcTA AAA domain + AMP + Mg
  • 5nss – EcTA in RNA polymerase complex – Cryo EM
• TenA TA
  • 1tyh, 1yaf – BsTA – Bacillus subtilis
  • 2qzc – TA – Sulfolobus solfataricus
  • 3no6 – TA – Staphylococcus epidermidis
  • 1yak – BsTA + pyrimidine derivative
  • 2qcx – BsTA (mutant) + pyrimidine derivative
  • 1udd – TA – Pyrococcus horikishii
• LasR TA or transcriptional regulator LasR
  • 6mww – PaTA – Pseudomonas aeruginosa
  • 2uv0 – PaTA LBD residues 1-173
  • 3ix3, 6mvn, 6mvm – PaTA LBD + oxo-dodecanoyl-homoserine lactone
  • 3ix4, 3ix8, 3jpu, 6d6a, 6d6b, 6d6c, 6d6d, **6d6p, 6d6l, 6d6m, 6d6o, 6d6n – PaTA LBD + benzoate derivative
  • 6mwl – PaTA + oxothiolan derivative
  • 6mwh – PaTA + acetamide derivative
  • 4ng2 – PaTA LBD + protein
  • 6mwz – PaTA (mutant) + peptide
  • 6v7w, 6v7x – PaTA + Aqs1
• CadC TA
  • 3ly7, 3lya – EcTA periplasmic domain 188-512
  • 3ly8, 3ly9 – EcTA periplasmic domain (mutant)
  • 5ju7 – EcTA DBD 2-107
• Mal-Rpel TA
  • 2v51, 2v52 – mTA residues 16-41 + actin
  • 2yje, 2yjf – mTA Rpel domain + actin
• Brg1 TA
  • 5ea1 – hTA bromodomain 1418-1536 - human
  • 3uvd – hTA bromodomain - NMR
  • 2grc, 3uvd, 5dkd, 6zs2 – hTA bromodomain + inhibitor
  • 6hr2 – hTA bromodomain + ElonginB + ElonginC + pVHL
  • 2i8b – TA C terminal – Zaire ebolavirus
  • 3v7o – TA C terminal – Reston ebolavirus
• Flagelar TA
  • 1g8e – EcTA FlhD
  • 2avu – EcTA FlhC+FLHD
  • 5hxg – StTA FlhD + STM1697
• Tipa TA
  • 1ny9 – SlTA antibiotic binding domain – Streptomyces lividans - NMR
  • 2mbz, 2mc0 - SlTA antibiotic binding domain + thiopeptide - NMR
  • 1r8d – BsTA
• Rfah TA
  • 2oug – EcTA
  • 2lcl – EcTA C terminal - NMR
  • 5ond – EcTA + DNA
• SoxR TA or redox-sensitive transcriptional activator
  • 2zhh – EcTA
  • 2zhg – EcTA + DNA
  • 6tf4 – VcTA C terminal - Vibrio cholera - NMR
• GlxR TA
  • 3r6s – CgTA +cAMP – Corynebacterium glutamicum
  • 4byy – CgTA
• OxyR TA or hydrogen peroxide-inducible genes activator
  • 3t22, 3ho7, 3uki – TA regulatory domain – Porphyromonas gingivalis
  • 7l4s – TA regulatory domain – Shewnella oneidensis
  • 4y0m – PaTA regulatory domain
  • 4x6g, 4xws – PaTA regulatory domain (mutant)
  • 1i69, 1i6a – EcTA regulatory domain (mutant)
  • 6g1d – CgTA regulatory domain (mutant)
  • 6g1b, 6g4r – CgTA regulatory domain + H2O2
  • 5x0v – VvTA - Vibrio vulnificus
  • 5b70, 5b7d, 5b7h, 5x0q – VvTA (mutant)
  • 3jv9 – NmTA – Neisseria meningitidis
• PlcR TA
  • 4fsc – BtTA - Bacillus thuringiensis
  • 2qfc – BtTA + PapR peptide
  • 3u3w – BtTA + DNA + PapR peptide
• VirB TA or virulence regulon transcriptional activator VirB
  • 3vwb, 3w2a, 3w3c – TA core domain + DNA – Shigella flexneri
• MafA TA
  • 4eot – hTA DBD
• CysB TA or Cys regulon transcriptional activator CysB
  • 4gwo, 4gxa, 4lon, 4lp2 – StTA C terminal – Salmonella typhimurium
  • 4lq2, 4lq5, 4m4g – StTA C terminal + acetylserine
  • 1al3 – TA cofactor binding domain – Klebsiella aerogenes
  • 5z50 – PaTA regulatory domain
  • 5z4y, 5z4z – PaTA NTD domain
• HlyU TA
  • 4k2e, 4ooi – VcTA
  • 3jth – VvTA
  • 5znx – VvTA + inhibitor
• ToxR TA
  • 6uue, 6utc – VvTA
  • 7nmb, 7nn6 – VcTA - NMR
  • 8b4b, 8b4c, 8b4d, 8b4e – VcTA + DNA
  • 8alo – VcTA + ToxS
• LysR TA
  • 5x0o – VvTA
  • 5x0n – VvTA (mutant)
  • 3t1b, 3szp – VcTA
  • 6tpr, 6z07, 6z17, 6z5k, 6yz3, 7o2t, 7o2u – PaTA + antagonist
  • 6yiz, 7nbw – PaTA + agonist
  • 5z7h – SaTA
  • 4pzj – TA – Eggerthella lenta
  • 3hhf, 3hhg, 4ab5 – NmTA
  • 3fzj – TA – Comamonas testosteroni
  • 1ixc, 1iz1 – CnTA – Cupriavidus necator
  • 5xxp, 7d98 – CnTA + DNA
  • 1uth, 2y7r, 5ae4 – TA – Burkholderia cepacia
  • 7trv, 7trw – TA LBD – Yersinia pestis
  • 7erp, 7erq – CsTA regulatory domain – Cronobacter sakazakii
  • 7fdf – CsTA regulatory domain (mutant)
• Aft2 TA
  • 4lmg – yTA + DNA
• Mga TA
  • 5way – SpTA – Streptococcus pneumoniae
• Spt7 TA
  • 6t9k, 6t9i – yTA in SAGA – Cryo EM
• Quorum-sensing TA or TraR
  • 5l07 – YeTA – Yersinia enterocolitica
  • 5l09 – YeTA + THF derivative
  • 1l3l – AtTA + pheromone + DNA – Agrobacterium tumefaciens
  • 1h0m – AtTA + auto-inducer + DNA
• MexT TA
  • 6l33 – PaTA regulatory domain
• ComR TA
  • 5juf, 6qer – StTA – Streptococcus thermophilus
  • 5jub – StTA + DNA
  • 5fd4 – TA – Streptococcus suis
  • 7n10, 7n1n – SmTA DBD + Prx – Streptococcus mutans
  • 6hu8 – SvTA – Streptococcus vestibularis
  • 6hua – SvTA + peptide
• FasR TA
  • 6o6p – MtTA + DNA – Mycobacterium tuberculosis
  • 6o6o – MtTA + myristic acid
  • 6o6n – MtTA + arachinoyl-CoA
• ModE TA
  • 1o7l, 1h9s – EcTA + Mo
  • 1b9m, 1b9n, 1h9r – EcTA + Ni
• TetR family TA
  • 1z77, 2id6, 2iek, 1zkg, 4i76, 3ih2, 3ih3, 3ih4 – TmTA – Thermotoga maritima
  • 4i6z – TmTA + DNA
  • 1zk8, 2fq4, 4me9 – BcTA – Bacillus cereus
  • 3cwr – TA – Rhodspirillum rubrum
  • 1z0x – EfTA – Enterococcus faecalis
  • 3c2b – AfTA – Agrobacterium fabrum
  • 2o7t – CgTA
  • 2g7s – AtTA
  • 3gzi – TA – Shewanella loihica
  • 2qib, 2zcx, 7ky1 – ScTA – Streptomyces coelicolor
  • 2hyt – TA – Pectobacterium atrosepticum
  • 3cdl – PsTA – Pseudomonas syringae
  • 3kkc – SaTA – Streptococcus agalactiae
  • 3nnr – TA – Marinobacter aquaeolei
  • 3on4 – TA – Legionella pneumophila
  • 3f1b – RjTA – Rhodococcus jostii
  • 3eup – TA – Cytophaga hutchinsonii
  • 3egq – TA – Archaeoglobus fulgidus
  • 4hku – LmTA – Listeria monocytogenes
  • 3nrg, 3qbm – TA – Chlotoflexus aurantiacus
  • 6nsr – PaTA (mutant) + DNA
  • 4jkz – MsTA – Mycobacterium smegmatis
  • 6el2 – SacTA – Sulfolobus acidocaldarius
  • 6en8 – SacTA + DNA
• TetR/AcrR family TA
  • 2rae – RjTA
  • 3lhq – StTA
  • 3b81 – CpTA – Clostridium acetobutylicum
  • 3dcf – TA – Thermobifida fusca
  • 3mvp – SmTA
  • 5d18, 5d19, 6a4l, 6a4w – MtTA
  • 2eh3 – TA – Aquifex aeolicus
  • 3vuq – TtTA – Thermus thermophilus
  • 7eqe – SgTA – Streptococcus griseus
  • 7eqf – SgTA + ligand
  • 5gp9, 5gpa – BhTA – Bacillus halodurans
  • 5gpc – BhTA + DNA
  • 6g87 – BdTA – Bradyrhizobium diazoefficiens
  • 6g8h – BdTA + naringenin
  • 6g8g – BdTA + genistein
• GntR family TA
  • 3l5z – BcTA
  • 3ddv – EfTA
  • 3fms, 3sxy – TmTA
  • 3c7j – PsTA
  • 2di3, 2p19 – CgTA
  • 3tqn – TA – Coxiella burnetii
  • 6za0, 6za3, 7za7 – AfTA
  • 6z74, 6zab – AfTA + DNA
  • 7u5q – TA – Brucella melitensis
  • 6sbs – SacTA
  • 3h5o – TA – Chromobacterium violaceum
  • 6az6, 7b5t, 7b5y, 7b5w – SaTA
  • 7b5u – SaTA + diAMP
  • 7oz3 – SaTA + DNA – Cryo EM
  • 4r1h – LmTA
  • 3ihu – TA – Ralstonia eutropha
  • 3lhe – TA – Bacillus anthracis
  • 3f8m – MsTA
• MarR family TA or multiple antibiotic resistance protein
  • 3boq, 3cjn, 3e6m – RpTA - Ruegeria pomeryi
  • 3s2w – TA – Methanosarcina mazei
  • 3bpv – TA – Methanobacterium thermoautotrophicum
  • 2fbk – DrTA – Deinococcus radiodurans
  • 5dd8 – DrTA (mutant)
  • 2fa5 – TA – Xanthomonas campestris
  • 3g3z, 5aiq – NmTA
  • 5aip – NmTA + hydroxyphenylacetate
  • 5e1w – DmTA – Dihalococcoides mccartyi
  • 5e1z, 5e1x, 5e20 – DmTA + phenol derivative
  • 6c28 – RpTA + coumaroyl-CoA – Rhodopseudomonas palustris
  • 3fm5 – RjTA
  • 1z91 – BsTA
  • 4b8x – ScTA
  • 4yif – MtTA
  • 3vb2, 3voe, 4jba – EcTA
  • 3vod – EcTA (mutant)
  • 5h3r – EcTA (mutant) + DNA
  • 5eri – CdTA – Clostridium difficile
  • 7dvn – TA + effector – Paenisporosarcina
  • 3u2r – TA – Planctopirus limnophilus
  • 2rdp – TA – Bacillus stearothermophilus
• MerR family TA or mercuric resistance operon regulatory protein
  • 3hh0 – BcTA
  • 3gpv – BtTA
  • 4ua1, 4ua2 – TA – Bacillus megaterium
  • 5crl – PaTA
  • 5gpe – TA – Cupriavidus metallidurans
  • 3cnb – TA – Colwellia psychrerythraea
  • 6d90 – HiTA – Haemophilia influenzae
  • 5d8c – HiTA + DNA
  • 6xl6, 6xla, 6xlk – EcTA + DNA – Cryo EM
  • 6xl5, 6xl9, 6xlj – EcTA in RNP complex – Cryo EM
• AsnC family TA
  • 3i4p – AfTA
  • 2cg4 – EcTA
• AraC family TA or arabinose operon regulatory protein
  • 3gra – PpTA – Pseudomonas putida
  • 3cu5 – TA – Lacnoclostridium phytofermentans
  • 5chh – PaTA
  • 2ara – EcTA
  • 1xja – EcTA dimerization domain (mutant)
  • 2k9s – EcTA DBD - NMR
  • 2arc – EcTA + arabinose
  • 2aac – EcTA + fucose
• LacI family TA
  • 3kjx, 3e3m – RpTA
  • 3jy6 – TA - Lactobacillus brevis
  • 6chk – LcTA - Lactobacillus casei
  • 4rk5, 4rk4 – LcTA + sugar
  • 4rk0, 4rk1 – EfTA + ribose
  • 3h5t – CgTA
  • 3kke – MsTA
  • 4rkq, 4rkr – TA - Arthrobacter
• PadR family TA
  • 5zhv, 5zi8, 5zhc – MtTA
  • 5zqh – SpTA
  • 5x12, 7cbv – BsTA
  • 5x13, 5y8t – BsTA + coumaric acid
  • 5x14 – BsTA + ferulic acid
  • 6abq, 6abt – LmTA
  • 5dym – CdTA
• TrmB TA or tRNA (guanine-N(7)-) methyltransferase
  • 2f5t – TA – Thermococcus litoralis
  • 3qph – PfTA + sucrose – Pyrococcus furiosus
• IclR TA
  • 1mkm – TmTA
  • 2o99, 2o9a – EcTA C-terminal
  • 1td5 – EcTA LBD
  • 7cuo – TA + hydroxybenzoate – Microbacterium hydrocarbonoxydans
    
    
• BgaR TA
  • 6nwo – CpTA – Clostridium perfringens
  • 6nx3, 6nwj, 6nwm, 6nwh – CpTA + pyranose derivative
• SlyA TA
  • 1lj9 – EfTA
  • 3qpt – StTA
  • 3q5f – StTA + DNA
  • 4aih – YpTA – Yersinia pseudotuberculosis
  • 4aij, 4aik – YpTA + DNA
• CouR TA
  • 5cyv, 6c28 – RjTA + coumaroyl-CoA – Rhodococcus jostii
  • 6c9t – RpTA
  • 6c2s – RpTA + DNA
• CueR TA
  • 1q07, 1q06, 1q05 – EcTA
• LuxR TA
  • 6wae – VvTA
  • 6wai, 6wah, 6wag, 6waf – VvTA (mutant)
• LuxT TA
  • 3b4s, 3ljl – VpTA
• ClgR TA or Clp gene regulator
  • 5woq – MsTA
  • 3f51, 3f52 – CgTA
• LmrR TA
  • 3f8b, 6i8n – LlTA – Lactococcus lactis
  • 3f8c, 3f8f – LlTA + drug
  • 6vwe, 6do0 – LlTA + Rh complex
  • 6r1l – LlTA + Cu + phenanthroline
  • 4zzd – LlTA + riboflavine
  • 6fuu – LlTA + heme
• MvfR TA
  • 4jvc, 6z17 – PaTA
  • 4jvd, 4jvi, 6q7u, 6q7v, 6tpr, 6yiz, 6yz3, 6z07, **6z17, 6z5k, 7nbw, 7o2t, 7o2u – PaTA + inhibitor
  • 6b8a, 6q7w – PaTA LBD 94-295 + inhibitor
• HdfR TA
  • 6wn5 – TA – Klebsiella pneumoniae
• McbR TA
  • 4p9f – EcTA
  • 4ab5 – MnTA
  • 4ab6 – MnTA (mutant)
• MetR TA
  • 5fo5 – EcTA DBD
• YvhJ TA
  • 3nxh – BsTA
• CgmR TA
  • 2yve, 2zoy – CgTA
  • 2zoz – CgTA + ethidium
  • 2yvh – CgTA + DNA
• AraR TA or arabinose metabolism transcriptional repressor
  • 5bs6, 5dd4 – BtTA – Bacterioides thetaiotaomicron
  • 3tb6 – BtTA effector-binding domain 71-362 + arabinose
  • 5ddg – BtTA + DNA
  • 5deq – BtTA 1-225 + arabinose
  • 4egy, 4egz, 4h0e, 5d4r, 5d4s – BsTA DBD 1-68 + DNA
• CarH TA or light-dependent transcriptional regulator
  • 5c8a, 5c8d, 5c8e, 5c8f – TtTA + cobalamin derivative
• ZitR TA or zinc transport transcriptional regulator
  • 5yhx – LlTA
  • 5yhy, 5yhz, 5yi0, 5yi1, 6fi9 – LlTA (mutant)
  • 5yi2 – LlTA + DNA
  • 5yi3 – LlTA (mutant) + DNA
• LsrR TA
  • 4l4y – EcTA
  • 4l4z, 4l50, 4l51, 4l5i, 4l5j – EcTA + ligand
• TA II
  • 8igr – EcTA in transcription activation complex – Cryo EM
• TA RAMA
  • 7bef, 7beg – EcTA in transcription activation complex – Cryo EM
• PrfA TA or listeriolysin positive regulatory factor A
  • 1omi, 2beo – LmTA
  • 2bgc, 6qvy, 6qvz, 6qw1, 6qw2 – LmTA (mutant)
  • 5lej, 5x6d – LmTA + DNA
  • 5lek, 6qwf, 6qwh, 6qwk, 6qwm – LmTA (mutant) + DNA
  • 5f1r, 6eut, 6euu, 6euz, 6ev0, 6exk, 6exl, 6exm, 6t5i – LmTA + inhibitor
  • 5lrs, 5x6e – LmTA + DNA + glutathione
  • 5lrr – LmTA + glutathione
  • 6hck – LmTA + peptide
• HTH-type TA or helix-turn-helix-type
  • 2uxu – PpTA TtgR + naringenin
  • 2uxh – PpTA TtgR + quercetin
  • 2uxi – PpTA TtgR + phloretin
  • 6ugl, 6kju – VcTA + pyrazine derivative<br />
  • 2bv6 – SaTA MgrA – Staphylococcus aureus
  • 5hs5, 5ywj, 6k8e – SaTA SarX
  • 3hrm, 3hse – SaTA SarZ
  • 6r1p – MtTA EthR
  • 1ysq – EcTA YiaJ
  • 2qop, 3bcg – EcTA AcrR
  • 6ldi, 6xh7, 6xh8, 7c17 – EcTA CueR in transcription activation complex – Cryo EM
  • 4wls, 4wlw – EcTA CueR + DNA
  • 4x1e – EcTA RutR
  • 4xk4, 4jyk – EcTA RutR + uracil derivative
  • 2hxr – EcTA CynR LBD
  • 3hfu – EcTA CynR LBD + N3
  • 8bob – EcTA MalT + MalY – Cryo EM
  • 2gfn – RjTA Rha1
  • 1i1g – PfTA LrpA
  • 7cla – TA SkgA – Caulobacter vibrioides
  • 7bzd – BsTA HxlR
  • 7bze – BsTA HxlR (mutant)
  • 7bzg – BsTA HxlR + DNA
  • 7amn, 7amt – TA LuxR + DNA – Vibrio alginolyticus
  • 2dtz, 2hq5 – SaTA QacR (mutant)
  • 3bqz, 3br0, 3btc, 3btl – SaTA QacR (mutant) + malachite green
  • 3br1, 3br2, 3bt9, 3btj – SaTA QacR (mutant) + dequalinium
  • 3bti – SaTA QacR (mutant) + berberine
  • 1qvu,3br3, 3pm1 – SaTA QacR (mutant) + ethidium
  • 1rkw, 1rpw – SaTA QacR (mutant) + pentamadine
  • 1qvt – SaTA QacR (mutant) + proflavine
  • 3br5, 3br6 – SaTA QacR (mutant) + rhodamine
  • 2gby – SaTA QacR (mutant) + berenil
  • 2g0e – SaTA QacR (mutant) + drug
  • 3k1n – AbTA BenM – Acinetobacter baylyi
  • 3k1p – AbTA BenM (mutant)
  • 2f6g, 2f6p, 2f97 – AbTA BenM effector-binding domain 81-304
  • 3m1e – AbTA BenM DBD 1-87
  • 4ihs, 4iht – AbTA BenM effector-binding domain + DNA
  • 2f78, 2f7a, 2f7c – AbTA BenM effector-binding domain + effector
  • 2h9b – EfTA BenM (mutant)
  • 2f7b, 2h98 – AbTA CatM effector-binding domain
  • 3glb – AbTA CatM effector-binding domain (mutant)
  • 2f7c – AbTA CatM effector-binding domain + muconate
  • 2cfx – BsTA LrpC
  • 2gqq – EcTA LrpC
  • 6d2s, 6cyj, 6cz6, 6cyy – MtTA PrpR
  • 2pju – EcTA PrpR
  • 5t4k, 5t4j, 5t4l, 5x03 – BsTA GabR EBO domain + pyridine derivative
  • 4mgr, 4nob, 4tv7 – BsTA GabR
  • 6uxz – BsTA GabR + agonist
  • 5u9e, 5u93 – TA RhaR regulatory domain – Bacteria latreille
  • 5z49 – TA CmpR effector-binding domain + ribulose bisphosphate – Synechococcus elongatus
  • 3kos – CfTA AmpR effector binding domain – Citrobacter freundii
  • 3kot – CfTA AmpR effector binding domain (mutant)
  • 4wkm – CfTA AmpR effector binding domain + peptide
  • 5mmh – PaTA AmpR effector binding domain
    

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