Undecaprenyl pyrophosphate synthase

spinqualitylabelsall models Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code 1x07). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Undecaprenyl pyrophosphate synthase or isoprenyl transferase or poly-cis-prenyltransferase or ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific) (UPPS) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall. UPPS or NUS1 is a subunit of cis-prenyltransferase. Bisphosphonate drugs are UPP inhibitors. Relevance UPPS inhibitors are investigated as potential antibacterials. Structural highlights The active site of UPPS (water molecules are shown as red spheres) contains an octahedrally coordinated Mg+2 ion bound to the pyrophosphate group of isopentenyl pyrophosphate. 3D structures of undecaprenyl pyrophosphate synthase Undecaprenyl pyrophosphate synthase 3D structures

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