Uridine 5'-monophosphate synthase

spinqualitylabelsall models Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP 2qcd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Uridine 5’-monophosphate synthase (UMPS) is a bifunctional enzyme which catalyzes the formation of uridine monophosphate (UMP). UMPS N-terminal domain is an orotate phosphoribosyltransferase (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is orotidine 5’-phosphate decarboxylase (OPD) or OMP decarboxylase which decarboxylates OMP to form UMP. Potent inhibitors of OPD are BMP – a barbituric acid derivative and xanthosine-5'-monophosphate (XMP). Disease Defects in UMPS result in the hereditary rare metabolic disease orotic aciduria. UMPS deficiency in Holstein cattle results in an autosomal disorder which causes early embryonic death of offspring. Structural highlights UMPS contains UMP in its nucleotide-binding pocket (the surface of chain B doesn't shown). Water molecules are shown as red spheres. 3D structures of uridine 5'-monophosphate synthase Uridine 5'-monophosphate synthase 3D structures

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