https://proteopedia.org/api.php?action=feedcontributions&feedformat=atom&user=Alyssa+Schwartz 2026-09-25T10:03:03Z User contributions MediaWiki 1.43.8 https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065650 2014-11-19T18:44:56Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> &lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;<br /> ==Structure==<br /> <br /> <br /> ==Function==<br /> <br /> Integrins are a class of surface proteins that bind to extracellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin. Integrin adhesion to the extra cellular matrix is key for cell ability to adhere, migrate and proliferate in both 2D and 3D systems. These will eventually form adhesion complexes, which regulate actomyocin polymerization. During migration, cells continually form new focal adhesions at the leading edge of the cell and release adhesion complexes at the back of the cell, enabling forward movement.<br /> <br /> Here are the &lt;scene name='60/609772/N-acetyl-d-glucosamine/2'&gt;N-acetyl-d-glucosamine locations!&lt;/scene&gt; N-acetyl-D-glucosamine may regulate integrin signaling during cancer cell migration.[1]<br /> <br /> ==Integrins and cancer==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies how cells process chemical and physical cues from the extracellular matrix and how these interactions play a role in the progression of cardiovascular disease and cancer. We aim to understand the downstream signaling pathways activated when cells use their integrins to bind to matrix and how this translates to the disease of interest. <br /> <br /> ==References==<br /> [1] C. Saravanan, F. Liu, I.K. Gipson and N. Panjwani1. Galectin-3 promotes lamellipodia formation in epithelial cells by interacting with complex N-glycans on 31 integrin. Journal of Cell Science 122, 3684-3693 Published by The Company of Biologists (2009). doi:10.1242/jcs.045674.</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065617 2014-11-19T18:09:59Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> &lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;<br /> ==Structure==<br /> <br /> <br /> Here are the &lt;scene name='60/609772/N-acetyl-d-glucosamine/2'&gt;N-acetyl-d-glucosamine locations!&lt;/scene&gt;<br /> ==Function==<br /> <br /> Integrins are a class of surface proteins that bind to extra cellular matrix components and transmit chemical and mechanical cues to internal signaling pathways. Integrin beta 1 binds many proteins when dimerized with an alpha subunit, including collagen, laminin and fibronectin. <br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies how cells process chemical and physical cues from the extracellular matrix, and how these interactions play a role in disease progression. By creating synthetic microenvironments, we are able to have tight control of cell-matirx interactions, allowing us to better understand how cells use their integrins to bind to matrix, and what downstream signaling pathways this binding sets off. <br /> <br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065596 2014-11-19T18:04:46Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> &lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;<br /> ==Structure==<br /> <br /> <br /> Here are the &lt;scene name='60/609772/N-acetyl-d-glucosamine/2'&gt;N-acetyl-d-glucosamine locations!&lt;/scene&gt;<br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies ...<br /> <br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065591 2014-11-19T18:04:04Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> &lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;<br /> ==Structure==<br /> <br /> <br /> Here are the N-acetyl-d-glucosamine locations! &lt;scene name='60/609772/N-acetyl-d-glucosamine/2'&gt;TextToBeDisplayed&lt;/scene&gt;<br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies ...<br /> <br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065566 2014-11-19T17:45:35Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> &lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;<br /> ==Integrin Beta 1==<br /> <br /> <br /> ==Structure==<br /> <br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies ...<br /> <br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065561 2014-11-19T17:44:18Z

<p>Alyssa Schwartz: </p> <hr /> <div>&lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> ==Integrin Beta 1==<br /> &lt;StructureSection load='3rec' size='350'&gt;<br /> <br /> ==Structure==<br /> <br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies ...<br /> <br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065545 2014-11-19T17:40:16Z

<p>Alyssa Schwartz: </p> <hr /> <div>&lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> ==Integrin Beta 1==<br /> &lt;StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''&gt;<br /> <br /> ==Structure==<br /> <br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==<br /> The [http://www.peytonlab.org/ Peyton lab] studies ...<br /> <br /> &lt;/StructureSection&gt;<br /> ==References==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065536 2014-11-19T17:34:51Z

<p>Alyssa Schwartz: </p> <hr /> <div>&lt;Structure load='3VI4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /&gt;One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration<br /> <br /> ==Structure==<br /> <br /> ==Function==<br /> <br /> ==Disease==<br /> <br /> ==Studying Integrin Beta-1'' in vitro''==<br /> <br /> ==Peyton Lab Research Interests==</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065468 2014-11-19T17:25:00Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins and allows for 3D ''in vitro'' cell migration</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=Molecular_Playground/IntegrinBeta1&diff=2065467 2014-11-19T17:24:45Z

<p>Alyssa Schwartz: </p> <hr /> <div>One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].<br /> Molecular Playground banner: '''&quot;<br /> <br /> '''Banner:''' Integrin Beta 1 binds to ECM proteins allows for 3D ''in vitro'' cell migration</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=User:Alyssa_Schwartz/Sandbox_1&diff=2060524 2014-11-19T00:10:03Z

<p>Alyssa Schwartz: New page: ==Your Heading Here (maybe something like &#039;Structure&#039;)== &lt;StructureSection load=&#039;1stp&#039; size=&#039;340&#039; side=&#039;right&#039; caption=&#039;Caption for this structure&#039; scene=&#039;&#039;&gt; This is a default text for you...</p> <hr /> <div>==Your Heading Here (maybe something like 'Structure')==<br /> &lt;StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''&gt;<br /> This is a default text for your page '''Alyssa Schwartz/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &amp;lt; and &amp;gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia &lt;ref&gt;DOI 10.1002/ijch.201300024&lt;/ref&gt; or to the article describing Jmol &lt;ref&gt;PMID:21638687&lt;/ref&gt; to the rescue.<br /> <br /> == Function ==<br /> <br /> == Disease ==<br /> Cancer<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to &lt;scene name=&quot;/12/3456/Sample/1&quot;&gt;color&lt;/scene&gt; by Group, and another to make &lt;scene name=&quot;/12/3456/Sample/2&quot;&gt;a transparent representation&lt;/scene&gt; of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> &lt;/StructureSection&gt;<br /> == References ==<br /> &lt;references/&gt;</div>

Alyssa Schwartz https://proteopedia.org/index.php?title=User:Alyssa_Schwartz&diff=2060523 2014-11-19T00:09:06Z

<p>Alyssa Schwartz: </p> <hr /> <div>* Full Real Name:Alyssa Schwartz<br /> <br /> * Position:graduate student<br /> <br /> * Institution (NO ABBREVIATIONS):University of Massachusetts Amherst<br /> <br /> * City, State/Province, Country:Amherst, MA, USA<br /> <br /> * Field of Expertise or Study:Chemical Engineering<br /> <br /> *[[User:Alyssa Schwartz/Sandbox 1]]</div>

Alyssa Schwartz