https://proteopedia.org/api.php?action=feedcontributions&feedformat=atom&user=Chad+SorensonProteopedia - User contributions [en]2026-10-05T19:48:18ZUser contributionsMediaWiki 1.43.8https://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012554Chad Sorenson sandbox 12009-11-02T03:50:01Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The structure on the bottom right shows pRb bound to E2F. Here, pRb is the green and blue structures. It is the same structure as above, but with added E2F sequences. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012538Chad Sorenson sandbox 12009-11-02T03:12:52Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The structure on the bottom right shows pRb bound to E2F. Here, pRb is the green and blue structures. It is the same structure as above, but with added E2F sequences. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
<scene name='Chad_Sorenson_sandbox_1/E2f_2/1'>TextToBeDisplayed</scene><br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012537Chad Sorenson sandbox 12009-11-02T03:09:38Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The structure on the bottom right shows pRb bound to E2F. Here, pRb is the green and blue structures. It is the same structure as above, but with added E2F sequences. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
<scene name='Chad_Sorenson_sandbox_1/E2f_2/1'>TextToBeDisplayed</scene><br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012536Chad Sorenson sandbox 12009-11-02T03:02:02Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The structure on the bottom right shows pRb bound to E2F. Here, pRb is the green and blue structures. It is the same structure as above, but with added E2F sequences. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012535Chad Sorenson sandbox 12009-11-02T02:59:12Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1012534Chad Sorenson sandbox 12009-11-02T02:54:10Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that regulates cell growth. It does this by preventing the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. Because of the absence of pRb, these cells have a very high change of becoming cancerous. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. It has been shown that mutations in the Rb gene could lead to reduced levels of pRb in other cancers including: Small Cell Lung Carcinomas (SCLC), bladder, breast, and a few others. <br />
<br />
<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
1. Horowitz, J. M., Park, S., Bogenmann, E., Cheng, J., Yandell, D., Kaye, F., Minna, J., Dryja, T., and Weinberg, R. (1990) ''Proc. Natl. Acad. Sci.'' Vol. 87, pp 2775-2779.<br />
2. http://en.wikipedia.org/wiki/Retinoblastoma_protein<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011993Chad Sorenson sandbox 12009-10-29T15:41:09Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
<scene name='Chad_Sorenson_sandbox_1/E2f/1'>TextToBeDisplayed</scene><br />
<br />
{{STRUCTURE_1o9k| PDB=1o9k | SCENE= }} <br />
<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011991Chad Sorenson sandbox 12009-10-29T15:40:13Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
<scene name='Chad_Sorenson_sandbox_1/E2f/1'>TextToBeDisplayed</scene><br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011989Chad Sorenson sandbox 12009-10-29T15:38:23Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011979Chad Sorenson sandbox 12009-10-29T15:20:33Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011978Chad Sorenson sandbox 12009-10-29T15:19:45Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
----<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011977Chad Sorenson sandbox 12009-10-29T15:15:26Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
[['''BACKGROUND''']]<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
[['''EXPERIMENTAL OBSERVATIONS IN TUMORS''']]<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011973Chad Sorenson sandbox 12009-10-29T15:10:08Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
Several genetics studies have been done on the RB gene and on its affect on many different types of cancer. In retinoblastoma tumors, there is no evidence of any pRb in these tumor cells. It has been concluded that RB gene inactivation is universal in all retinoblastomas and that pRb is rapidly degraded in these tumors. The inactivation of the RB gene is universal in retinoblastomas, but it plays a factor in many other cancers as well. <br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011972Chad Sorenson sandbox 12009-10-29T15:01:41Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in many types of cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''EXPERIMENTAL OBSERVATIONS IN TUMORS'''<br />
<br />
<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011970Chad Sorenson sandbox 12009-10-29T14:58:44Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/E2f_and_prb/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''Experimental Observations in Tumors'''<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011969Chad Sorenson sandbox 12009-10-29T14:52:04Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F <scene name='Chad_Sorenson_sandbox_1/Prb_and_e2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''Experimental Observations in Tumors'''<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011967Chad Sorenson sandbox 12009-10-29T14:51:01Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). You can see pRb bound to E2F me='Chad_Sorenson_sandbox_1/Prb_and_e2f/1'>here</scene>. The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''Experimental Observations in Tumors'''<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011927Chad Sorenson sandbox 12009-10-29T04:07:57Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''Experimental Observations in Tumors'''<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011899Chad Sorenson sandbox 12009-10-29T02:40:02Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
[[<br />
'''BACKGROUND''']]<br />
<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
[[<br />
'''Experimental Observations in Tumors''']]<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011898Chad Sorenson sandbox 12009-10-29T02:39:09Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
'''Experimental Observations in Tumors'''<br />
<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011897Chad Sorenson sandbox 12009-10-29T02:28:13Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein (pRb)is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. <br />
<br />
Retinoblastoma protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>). At the interface of these two domains, there is a pocket that is able to bind and inhibit E2F (transcription factor). The role of E2F is to promote the cell into the S phase. Since pRb binds E2F, then it inhibits the cell from entering the S phase. pRb is active when it is not phosphorylated, however when cyclin-dependent kinases (CDK) and cyclins phosphorylate pRb it inactivates the protein. Once it becomes phosphorylated, it releases E2F and then the cell can enter the S phase.<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011895Chad Sorenson sandbox 12009-10-29T02:15:48Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. The protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene> and <br />
<scene name='Chad_Sorenson_sandbox_1/Domain_b/1'>Domain B</scene>).<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011892Chad Sorenson sandbox 12009-10-29T02:10:41Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer. The protein has two main domains (<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>Domain A</scene>)<br />
<br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011891Chad Sorenson sandbox 12009-10-29T01:51:12Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer.<br />
<br />
<scene name='Chad_Sorenson_sandbox_1/Domain_a/2'>TextToBeDisplayed</scene><br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011889Chad Sorenson sandbox 12009-10-29T01:45:25Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
'''BACKGROUND'''<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. This protein is one that is commonly mutated in cancer. The retinoblastoma gene that codes for the protein is a tumor suppressor gene, or a gene that protects a cell from one step on the path to cancer. One can tell early in one's life if they possess mutations in this gene because often mutations in this gene cause the person to develop retinoblastoma cancer, hence the name retinoblastoma. While retinoblastoma cancer is located in the eye, the protein is found in all cells in the human body. It is currently unknown why early mutations in this gene cause retinoblastoma cancer.<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011888Chad Sorenson sandbox 12009-10-29T01:37:53Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
<br />
== '''RETINOBLASTOMA PROTEIN''' ==<br />
<br />
<br />
BACKGROUND<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. <br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011887Chad Sorenson sandbox 12009-10-29T01:36:57Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
'''RETINOBLASTOMA PROTEIN'''<br />
<br />
BACKGROUND<br />
<br />
Retinoblastoma protein is a regulatory protein that prevents the cell from replicating damaged DNA. It thus keeps the cell in the G1 phase and does not allow the cell to enter the S phase with damaged DNA. <br />
<br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011885Chad Sorenson sandbox 12009-10-29T01:31:27Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:1gux.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_1gux", creates the "Structure Box" on the page.<br />
You may change the PDB parameter (which sets the PDB file loaded into the applet) <br />
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_1gux| PDB=1gux | SCENE= }} <br />
<br />
===RB POCKET BOUND TO E7 LXCXE MOTIF===<br />
<br />
<br />
<!-- <br />
The line below this paragraph, {{ABSTRACT_PUBMED_9495340}}, adds the Publication Abstract to the page <br />
(as it appears on PubMed at http://www.pubmed.gov), where 9495340 is the PubMed ID number.<br />
--><br />
{{ABSTRACT_PUBMED_9495340}}<br />
<br />
==About this Structure==<br />
1GUX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUX OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:9495340</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Human papillomavirus]]<br />
[[Category: Lee, J O.]]<br />
[[Category: Pavletich, N P.]]<br />
[[Category: Russo, A A.]]<br />
[[Category: Retinoblastoma]]<br />
[[Category: Tumor suppressor protein]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:09:11 2009''</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011876Chad Sorenson sandbox 12009-10-29T00:44:39Z<p>Chad Sorenson: </p>
<hr />
<div>{{Seed}}<br />
[[Image:2r7g.png|left|200px]]<br />
<br />
<!--<br />
The line below this paragraph, containing "STRUCTURE_2r7g", creates the "Structure Box" on the page.<br />
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),<br />
or leave the SCENE parameter empty for the default display.<br />
--><br />
{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
<br />
===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A (<scene name='Chad_Sorenson_sandbox_1/Domain_a/1'>(Domain A)</scene>)and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=1011875Chad Sorenson sandbox 12009-10-29T00:31:42Z<p>Chad Sorenson: </p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
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===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A (<scene name='Chad_Sorenson_sandbox_1/Domain_a/1'>(Domain A)</scene>)and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br />
<br />
<scene name='Chad_Sorenson_sandbox_1/20-25/1'>TextToBeDisplayed</scene></div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=998788Chad Sorenson sandbox 12009-09-22T04:15:55Z<p>Chad Sorenson: </p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
<br />
===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A (<scene name='Chad_Sorenson_sandbox_1/Domain_a/1'>(Domain A)</scene>)and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=998787Chad Sorenson sandbox 12009-09-22T04:15:26Z<p>Chad Sorenson: </p>
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[[Image:2r7g.png|left|200px]]<br />
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
<br />
===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=998786Chad Sorenson sandbox 12009-09-22T04:12:16Z<p>Chad Sorenson: </p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
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===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
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{{ABSTRACT_PUBMED_17974914}}</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=998785Chad Sorenson sandbox 12009-09-22T04:11:11Z<p>Chad Sorenson: </p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
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===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
<!-- <br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br />
--></div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=998784Chad Sorenson sandbox 12009-09-22T04:09:35Z<p>Chad Sorenson: </p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
<br />
===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
<br />
<br />
<!-- <br />
Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain<br />
Publication Abstract from PubMed<br />
<br />
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A (<scene name='Chad_Sorenson_sandbox_1/Domain_a/1'>(Domain A)</scene>) and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.<br />
<br />
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor., Liu X, Marmorstein R, Genes Dev. 2007 Nov 1;21(21):2711-6. PMID:17974914<br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Chad_Sorenson_sandbox_1&diff=994750Chad Sorenson sandbox 12009-09-10T14:20:25Z<p>Chad Sorenson: New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2r7g", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the P...</p>
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{{STRUCTURE_2r7g| PDB=2r7g | SCENE= }} <br />
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===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===<br />
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{{ABSTRACT_PUBMED_17974914}}</div>Chad Sorensonhttps://proteopedia.org/index.php?title=Ann_Taylor_sandbox_8&diff=990831Ann Taylor sandbox 82009-09-01T14:56:37Z<p>Chad Sorenson: </p>
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[[Image:3d06.jpg|left|200px]]<br />
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{{STRUCTURE_3d06| PDB=3d06 | SCENE= }} <br />
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===Human p53 core domain with hot spot mutation R249S (I)===<br />
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<br />
Publication Abstract from PubMed<br />
--------------------------------------------------------------------------------<br />
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The tumor suppressor protein p53 is mutated in more than 50% of invasive cancers. About 30% of the mutations are found in six major "hot spot" codons located in its DNA binding core domain. To gain structural insight into the deleterious effects of such mutations and their rescue by suppressor mutations, we determined the crystal structures of the p53 core domain incorporating the hot spot mutation <scene name='Ann_Taylor_sandbox_8/R249s/1'>R249S</scene>, the core domain incorporating R249S and a second-site suppressor mutation H168R (referred to as the double mutant R249S/H168R) and its sequence-specific complex with DNA and of the triple mutant R249S/H168R/T123A. The structural studies were accompanied by transactivation and apoptosis experiments. The crystal structures show that the region at the vicinity of the mutation site in the R249S mutant displays a range of conformations [wild-type (wt) and several mutant-type conformations] due to the loss of stabilizing interactions mediated by R249 in the wt protein. As a consequence, the protein surface that is critical to the formation of functional p53-DNA complexes, through protein-protein and protein-DNA interactions, is largely distorted in the mutant conformations, thus explaining the protein's "loss of function" as a transcription factor. The structure of this region is restored in both R249S/H168R and R249S/H168R/T123A and is further stabilized in the complex of R249S/H168R with DNA. Our functional data show that the introduction of H168R as a second-site suppressor mutation partially restores the transactivation capacity of the protein and that this effect is further amplified by the addition of a third-site mutation T123A. These findings together with previously reported data on wt and mutant p53 provide a structural framework for understanding p53 dysfunction as a result of oncogenic mutations and its rescue by suppressor mutations and for a potential drug design aimed at restoring wt activity to aberrant p53 proteins. <br />
<br />
Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations., Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z, J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 <br />
<br />
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. <br />
<br />
<br />
==Disease==<br />
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]]<br />
<br />
==About this Structure==<br />
3D06 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D06 OCA]. <br />
<br />
==Reference==<br />
<ref group="xtra">PMID:18996393</ref><references group="xtra"/><br />
[[Category: Homo sapiens]]<br />
[[Category: Frolow, F.]]<br />
[[Category: Rozenberg, H.]]<br />
[[Category: Shakked, Z.]]<br />
[[Category: Shimon, L J.W.]]<br />
[[Category: Suad, O.]]<br />
[[Category: Acetylation]]<br />
[[Category: Activator]]<br />
[[Category: Alternative splicing]]<br />
[[Category: Anti-oncogene]]<br />
[[Category: Apoptosis]]<br />
[[Category: Cell cycle]]<br />
[[Category: Covalent protein-rna linkage]]<br />
[[Category: Cytoplasm]]<br />
[[Category: Disease mutation]]<br />
[[Category: Dna-binding]]<br />
[[Category: Endoplasmic reticulum]]<br />
[[Category: Glycoprotein]]<br />
[[Category: Host-virus interaction]]<br />
[[Category: Li-fraumeni syndrome]]<br />
[[Category: Loop-sheet-helix motif]]<br />
[[Category: Metal-binding]]<br />
[[Category: Methylation]]<br />
[[Category: Mutant protein]]<br />
[[Category: Nucleus]]<br />
[[Category: P53]]<br />
[[Category: Phosphoprotein]]<br />
[[Category: Polymorphism]]<br />
[[Category: Transcription]]<br />
[[Category: Transcription regulation]]<br />
[[Category: Ubl conjugation]]<br />
[[Category: Zinc]]<br />
<br />
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:44:12 2009''</div>Chad Sorenson