Proteopedia - User contributions [en]

User:Claude Sauter/GFLV

2019-01-31T16:02:10Z

Claude Sauter: New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='4v5t' size='340' side='right' caption='Grapevine fanleaf virus' scene=''> This is a default text for your p...

==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='4v5t' size='340' side='right' caption='Grapevine fanleaf virus' scene=''>
This is a default text for your page '''Claude Sauter/GFLV'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Structural highlights ==
[[4v5t]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Grapevine_fanleaf_virus Grapevine fanleaf virus].

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

</StructureSection>
== References ==
<references/>

== Publication Abstract from PubMed ==
Many animal and plant viruses rely on vectors for their transmission from host to host. Grapevine fanleaf virus (GFLV), a picorna-like virus from plants, is transmitted specifically by the ectoparasitic nematode Xiphinema index. The icosahedral capsid of GFLV, which consists of 60 identical coat protein subunits (CP), carries the determinants of this specificity. Here, we provide novel insight into GFLV transmission by nematodes through a comparative structural and functional analysis of two GFLV variants. We isolated a mutant GFLV strain (GFLV-TD) poorly transmissible by nematodes, and showed that the transmission defect is due to a glycine to aspartate mutation at position 297 (Gly297Asp) in the CP. We next determined the crystal structures of the wild-type GFLV strain F13 at 3.0 A and of GFLV-TD at 2.7 A resolution. The Gly297Asp mutation mapped to an exposed loop at the outer surface of the capsid and did not affect the conformation of the assembled capsid, nor of individual CP molecules. The loop is part of a positively charged pocket that includes a previously identified determinant of transmission. We propose that this pocket is a ligand-binding site with essential function in GFLV transmission by X. index. Our data suggest that perturbation of the electrostatic landscape of this pocket affects the interaction of the virion with specific receptors of the nematode's feeding apparatus, and thereby severely diminishes its transmission efficiency. These data provide a first structural insight into the interactions between a plant virus and a nematode vector.

Structural Insights into Viral Determinants of Nematode Mediated Grapevine fanleaf virus Transmission.,Schellenberger P, Sauter C, Lorber B, Bron P, Trapani S, Bergdoll M, Marmonier A, Schmitt-Keichinger C, Lemaire O, Demangeat G, Ritzenthaler C PLoS Pathog. 2011 May;7(5):e1002034. Epub 2011 May 19. PMID:21625570<ref>PMID:21625570</ref>

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:50:18Z

Claude Sauter:

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
The high resolution structure of a <scene name='80/807446/Rna9bp/1'>small RNA duplex</scene> (2x9) [[485d]] shows a <scene name='80/807446/Sulfate_ion/2'>binding pocket</scene> for a <scene name='80/807446/Sulfate_ion/4'>sulfate ion</scene>.

<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:46:30Z

Claude Sauter:

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
The high resolution structure of a small RNA duplex (2x9) [[485d]] shows a <scene name='80/807446/Sulfate_ion/2'>binding pocket</scene> for a <scene name='80/807446/Sulfate_ion/4'>sulfate ion</scene>.

<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:41:24Z

Claude Sauter:

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
The high resolution structure of a small RNA duplex (2x9) [[485d]] shows a <scene name='80/807446/Sulfate_ion/2'>binding pocket</scene> for a <scene name='80/807446/Sulfate_ion/3'>sulfate ion</scene>.

<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:36:07Z

Claude Sauter:

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
The high resolution structure of a small RNA duplex (2x9) [[485d]] shows a <scene name='80/807446/Sulfate_ion/2'>binding pocket</scene> for a sulfate ion.

<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:27:22Z

Claude Sauter:

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
The high resolution structure of a small RNA (2x9) [[485d]] shows a <scene name='80/807446/Sulfate_ion/1'>binding pocket</scene> for a sulfate ion.

<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:08:18Z

Claude Sauter: /* A SULFATE POCKET FORMED BY THREE GOU PAIRS IN THE STRUCTURE OF A NONAMERIC RNA */

==A SULFATE POCKET IN THE STRUCTURE OF A SMALL RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>

== Structural highlights ==
<table><tr><td colspan='2'>[[485d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=485D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=485D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=485d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=485d OCA], [http://pdbe.org/485d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=485d RCSB], [http://www.ebi.ac.uk/pdbsum/485d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=485d ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter/rna sulfate pocket

2019-01-31T15:07:15Z

Claude Sauter: New page: ==A SULFATE POCKET FORMED BY THREE GOU PAIRS IN THE STRUCTURE OF A NONAMERIC RNA== <StructureSection load='485d' size='340' side='right' caption='485d, resolution 0.97&A...

==A SULFATE POCKET FORMED BY THREE GOU PAIRS IN THE STRUCTURE OF A NONAMERIC RNA==
<StructureSection load='485d' size='340' side='right' caption='[[485d]], [[Resolution|resolution]] 0.97Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[485d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=485D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=485D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=485d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=485d OCA], [http://pdbe.org/485d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=485d RCSB], [http://www.ebi.ac.uk/pdbsum/485d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=485d ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the RNA duplex [r(CGUGAUCG)dC]2 has been solved at a resolution of 0.97 A. The model has been refined to R-work and R-free of 14.88% and 19.54% for 23,838 independent reflections. The base-pairing scheme forces the 5'-rC to be excluded from the helix and to be disordered. In the crystals, the sequence promotes the formation of two GoU wobble pairs that cluster around a crystallographic threefold axis in two different ways. In the first contact type, the GoU pairs are exclusively surrounded by water molecules, whereas in the other contact type, the three amino groups of the guanine residues of the symmetry-related GoU pairs trap a sulfate ion. This work provides the first example of the interaction of a GoU pair with a sulfate ion in a helical context. Despite the negative charge on the polynucleotide backbone, the guanine amino N2 is able to attract negatively charged groups that could, in the folding of complex RNA molecules, belong to a negative phosphodiester group from a neighboring strand and, in a RNA-protein complex, to a negative carboxyl group of an aspartate or glutamate side chain.

A sulfate pocket formed by three GoU pairs in the 0.97 A resolution X-ray structure of a nonameric RNA.,Masquida B, Sauter C, Westhof E RNA. 1999 Oct;5(10):1384-95. PMID:10573129<ref>PMID:10573129</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 485d" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Masquida, B]]
[[Category: Sauter, C]]
[[Category: Westhof, E]]
[[Category: Dna-rna hybrid complex]]
[[Category: Dna/rna hybrid]]
[[Category: Rna]]
[[Category: Sulfate ion]]

User:Claude Sauter

2019-01-31T15:00:28Z

Claude Sauter:

* Full Real Name: Claude Sauter [[Image:ClaudeSauter.jpg|right|200px]]

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>

User:Claude Sauter

2019-01-31T14:59:56Z

Claude Sauter:

* Full Real Name: Claude Sauter [[Image:ClaudeSauter.jpg|right|100px]]

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>

User:Claude Sauter

2019-01-31T14:58:17Z

Claude Sauter:

* Full Real Name: Claude Sauter [[Image:ClaudeSauter.jpg]]

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>

User:Claude Sauter

2019-01-31T14:57:14Z

Claude Sauter:

* Full Real Name: Claude Sauter [[Image:claudesauter.jpg]]

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>

File:ClaudeSauter.jpg

2019-01-31T14:56:24Z

Claude Sauter:

User:Claude Sauter

2019-01-31T14:53:03Z

Claude Sauter:

* Full Real Name: Claude Sauter [[Image:Example.jpg]]

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>

User:Claude Sauter

2019-01-31T14:50:47Z

Claude Sauter:

* Full Real Name: Claude Sauter

* Position: Research Director

* Institution (NO ABBREVIATIONS): Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire Cellulaire

* City, State/Province, Country: Strasbourg, France

* Field of Expertise or Study: protein/rna complexes, integrative structural biology, crystallogenesis

<html5media height="300" width="400">https://www.youtube.com/watch?v=GfOyZch6llo</html5media>