Proteopedia - User contributions [en]

Molecular Playground/Trypsin

2010-05-14T16:18:52Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='Trypsin catalytic site' />

<scene name='Molecular_Playground/Trypsin/Trypsin/5'>Trypsin</scene>

==Trypsin==
Trypsin is a serine protease that is used as a tool to aid in protein
identification by cleaving the protein on the c-terminal of Lysine and
arginine residues resulting in peptides with lower molecular weights.

Banner: Scene shows the catalytic site where trypsin cleaves amide bonds

Molecular Playground/TRAIL

2010-05-14T13:43:34Z

David Griffin:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,338]' frame='true' align='right'
caption='TRAIL' />

<scene name='User:Charles_Swofford/Sandbox_1/1/21'>TRAIL</scene>

Molecular Playground Banner: TRAIL, a novel cancer therapeutic

TRAIL, or tumor-necrosis factor apoptosis-inducing ligand, is a member of the TNF superfamily that has attracted attention for its specificity towards cancer cells with limited toxicity towards most normal cells. TRAIL is a type II transmembrane protein with an extracellular domain that can be proteolyticly cleaved, and which forms a homotrimer that binds three monomeric death receptors (DRs). It binds to DR4 and DR5, which elicit signal transduction of caspase-8 mediated apoptosis via the death receptor pathway, or it can bind to the decoy receptors (DcR1, DcR2, or osteoprotegerin) which have truncated or non-functional intracellular death domains. Receptor binding by TNFα can stimulate both pro-apoptotic signals (via caspase-8) and anti-apoptotic signals (via NFκB). However, TRAIL has attenuated induction of NFκB, leading to a pronounced death signal via a p53-independent mechanism. In addition, the antagonistic decoy receptors are widely-expressed in normal tissues and confer a resistance to TRAIL-mediated apoptosis.

This scene shows only the extracellular domain of TRAIL. Each beta-sheet is shown in a different color and the bright green loop designates the section of the protein which is responsible for binding with the various death receptors.

Molecular Playground/Alginate

2010-05-12T17:18:21Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has thus found numerous applications as a biomaterial for cellular engineering. Owing to its unique physical properties, alginate hydrogels have been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and as a vector for the targeted delivery of anti-cancer drugs.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source. The ratio of G/M in the chain influences the strength of alginate hydrogels and can be tuned by combining alginate obtained from different organisms. The rotating molecule to the right is an example of a short chain of sodium alginate.

Molecular Playground banner: A short, linear chain of sodium alginate.

Molecular Playground/Alginate

2010-05-02T23:19:24Z

David Griffin:

CBI Molecules

2010-05-02T23:12:27Z

David Griffin:

These are molecules under study by members of the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program].
Many of the molecules we study are featured at the [http://www.molecularplayground.org/ Molecular Playground]. Follow the links below to read nontechnical descriptions in Proteopedia.

UMass CBI Members, add your molecules to the list; follow the instructions below the list.

'''[[Molecular Playground/Bacterial Chemotaxis Receptors]]''', [http://people.chem.umass.edu/thompson/index.html Thompson] & [http://www.chem.umass.edu/~rmweis/weislab/ Weis] laboratories

'''[[6-deoxyerythronolide B synthase (DEBS)|Molecular Playground/6-Deoxyerythronolide B Synthase]]''', Schnarr lab (Tsung-Yi Lin)

'''[[Molecular Playground/Lysozime ]]''', Daniella Gonzalez, Thayumanavan Research Group

'''[[Molecular Playground/Beta-galactosidase]]''', Judy Ventura, Thayumanavan Research group

'''[[Molecular Playground/TRAIL]]''', Charley Swofford

'''[[Molecular Playground/Taxol]]''', [http://robertsgroup.ecs.umass.edu/ Roberts Research Group] (Rohan Patil)

'''[[Molecular Playground/Human Protective Protein Cathepsin A]]''', Yadilette Rivera-Colon, [http://www.biochem.umass.edu/garman/index.html Garman Research Group]

'''[[Molecular Playground/YKL-40]]''', Ralph A. Francescone III, [http://www.bio.umass.edu/mcb/faculty/Shao.html Shao Lab]

'''[[Reverse transcriptase|Molecular Playground/Reverse Transcriptase]]''', Rotello lab (Daniel Moyano-Marino)

'''[[User:Krishna Reddy Ragupathi|Molecular Playground/Carbonic Anhydrase]]''', Thai lab (Krishna Reddy Raghupathi)

'''[[User:Rami Rajasekhar Reddy|Molecular Playground/Avidin]]''', Thai lab (Rami Rajasekar Reddy)

'''[[Molecular_Playground/ERMan1]]''', Johan Sunryd

'''[[Molecular Playground/Insulin]]''', [http://robertsgroup.ecs.umass.edu/ Roberts Research Group] (Whitney Stoppel)

'''[[Molecular Playground/T7 RNA Polymerase (7 mer int)]]''', Ankit Vahia ([http://www.chem.umass.edu/~cmartin/ Martin] lab)

'''[[Molecular Playground/Human PPCA]]''', Nilima Kolli ([http://www.biochem.umass.edu/garman/index.html Garman Lab])

'''[[Molecular Playground/Alginate]]''', Bhatia Research Group (David Griffin)

'''[[Molecular Playground/Glutamate Receptor]]''', [http://chamberslab.com/wp/ Chambers Lab] (Amanda Hussey, Steve McCarron, Rosie Combs-Bachmann, Mariel Feliciano)

'''[[Molecular Playground/Biotin binding avidin]]''', Diego Amado (Thai Lab)

'''[[Molecular Playground/FIH]]''', Knapp Lab, (Cornelius Taabazuing, Breanne Holmes, John Hangasky)

'''[[User:Jiaming Zhuang|Molecular Playground/MMP12]]''', Thai lab (Jiaming Zhuang)

'''[[Molecular Playground/Pancreatic Lipase]]''', [http://www.umass.edu/rotellogroup/ Rotello lab] (Rui Tang)

'''[[Molecular Playground/Trypsin]]''', Thai-Vachet lab (Murage, Gladys)

'''[[Molecular playground/beta 2 microglobulin]]''', Vachet lab (Nick)

''' [[User:Jing Guo|Molecular Playground/Gluconase]]''', Thai lab (Jing Guo)

'''[[Molecular playground/Chymotrypsin]]''', Rotello lab (Brad)

'''[[CRABP I ( Cellular Retinoic Acid Binding Protein )|Molecular Playground/CRABP I]]''', [http://people.chem.umass.edu/gieraschlab/ Gierasch Lab] (Kristine Faye Pobre, Mylene Ferrolino,Mangai Periasamy)

'''[[Molecular Playground/Prolyl Hydroxylase Domain (PHD) Enzyme]]''', Knapp lab (Cristina Martin)

'''[[Molecular Playground/Glutathione Reductase]]''', Thai Lab (Reuben Chacko)

'''[[Molecular Playground/Velaglucerase]]''', Adriana Kita, Kaltashov Lab

Instructions:

'''We plan to award a prize for the best CBI Molecules page and/or scene!'''

Choose a molecule that is part of your research project.

1. If you don't already have one, request a Proteopedia account and log in. If you are new to Proteopedia, click Help in the navigation box on the left to get started.

2. Make yourself a sandbox page in which you will develop your CBI Molecule scene and description (Enter "User:your name/sandbox 1" (omit quotes) in the search box, then follow instructions to edit this page. See example [[User:Lynmarie K Thompson/Sandbox 1]]).

3. Follow the format of the sample CBI molecule page [[Molecular Playground/Bacterial Chemotaxis Receptors]]. Easiest way to do this is to copy this page (in editing mode), paste it into your sandbox page, keep the first paragraph about CBI molecules, and then edit to describe and display your molecule. Your goal is to make this an interesting, nontechnical description of the molecule. If multiple people in one group work on the same molecule, you can each make different scenes for the same CBI molecule and each describe them on the same proteopedia page. Talk with each other about your plans so you are not duplicating efforts.

4. Create an attractive scene for your molecule: use the scene authoring tools in the edit mode to create the view you like, then copy the wiki text into your window.

5. Follow instructions at [[Molecular Playground/Procedures]] as well. But don't "capture the state script for your scene"; that will be done for you (see #7). With your chosen Jmol scene for the Molecular Playground, specify a "banner", which will be projected with the molecule on the Molecular Playground. This should be a short, one-line headline for your scene that includes the name of the molecule and what is important about the scene or the molecule. Remember to design this for the general public, including non-scientists. My example is: "Molecular Playground banner: A bacterial chemotaxis receptor protein used by bacteria to "smell" their environment."

6. When you are happy with your sandbox page, make yourself a permanent Proteopedia page, which will be editable by others. Enter "Molecular Playground/your molecule" (omit quotes) in the search box, then follow the instructions to create a new page with this title. Copy the content of your sandbox to this new page.

7. When you have finished the final version of your page and scene, edit this CBI Molecules page to add a listing and link for your molecule, following the "Bacterial chemotaxis receptors" example above. Please list your lab group, with your name in parentheses. That way more than one name can be associated with a Molecular Playground page (if there are several students on the Molecular Playground page, please indicate your scene with your initials). It would be great to link the lab names to web pages too. Once this link is there, your scene is considered done, and someone will capture the state script for display on the Molecular Playground.

CBI Molecules

2010-04-30T18:08:45Z

David Griffin:

Molecular Playground/Alginate

2010-04-30T18:06:22Z

David Griffin: New page: Alginate monomers One of the CBI Molecules being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface P...

User:David Griffin/Sandbox 1

2010-04-30T18:03:18Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:57:59Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has thus found numerous applications as a biomaterial for cellular engineering. Owing to its unique physical properties, alginate hydrogels have been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source. The ratio of G/M in the chain influences the strength of alginate hydrogels and can be tuned by combining alginate obtained from different organisms. The rotating molecule to the right is an example of a short chain of sodium alginate.

User:David Griffin/Sandbox 1

2010-04-30T17:56:35Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has thus found numerous applications as a biomaterial for cellular engineering. Owing to its unique physical properties, alginate hydrogels have been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source. The ratio of G/M in the chain influences the strength of alginate hydrogels and can be tuned by combining alginate obtained from different organisms. The spinning molecule to the right is an example of a short chain of sodium alginate.

User:David Griffin/Sandbox 1

2010-04-30T17:52:51Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has found numerous applications as a biomaterial for cellular engineering. Owing to its unique physical properties, alginate hydrogels have been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source. The ratio of G/M in the chain influences the strength of alginate hydrogels and can be tuned by combining alginate obtained from different organisms. The spinning molecule to the right is an example of a short chain of sodium alginate.

User:David Griffin/Sandbox 1

2010-04-30T17:47:38Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from certain bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has found numerous applications as a biomaterial for cellular engineering.

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. The ratio of G/M in the alginate chain influences the strength of the gel and can be tuned by combining alginate obtained from different sources.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Owing to its unique physical properties, alginate hydrogels have been used for a number of biomaterial applications. Alginate has been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

The spinning molecule to the right is an example of a short chain of sodium alginate. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source.

User:David Griffin/Sandbox 1

2010-04-30T17:46:58Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from certain bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has found numerous applications as a biomaterial for cellular engineering.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. The ratio of G/M in the alginate chain influences the strength of the gel and can be tuned by combining alginate obtained from different sources.

Owing to its unique physical properties, alginate hydrogels have been used for a number of biomaterial applications. Alginate has been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

The spinning molecule to the right is an example of a short chain of sodium alginate. Alginate can vary widely in length, monomeric sequence and G/M ratio depending on the source.

User:David Griffin/Sandbox 1

2010-04-30T17:45:43Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from certain bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has found numerous applications as a biomaterial for cellular engineering.

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. The ratio of G/M in the alginate chain influences the strength of the gel and can be tuned by combining alginate obtained from different sources.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Owing to its unique physical properties, alginate hydrogels have been used for a number of biomaterial applications. Alginate has been used as a scaffold material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

The spinning molecule to the right is an example of a short chain of sodium alginate. Alginate chains vary widely in length, monomeric sequence and G/M ratio depending on the source.

User:David Griffin/Sandbox 1

2010-04-30T17:40:38Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Alginate is a linear, organic polymer isolated from certain bacteria and algae. It has been shown to be biocompatible (non-toxic to human cells) and has found numerous applications as a biomaterial for cellular engineering.

Alginate is composed of a random sequence of mannuronic acid (M) and guluronic acid (G). Exposure to divalent cations (e.g. calcium, magnesium, etc.) chemically cross-links alginate solutions forming a gel. The ratio of G/M in the alginate chain influences the strength of the gel and can be tuned by combining alginate obtained from different sources.

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da)' scene='User:David_Griffin/Sandbox_1/Alginate_24000da/1'/>

Owing to its unique physical properties, alginate hydrogels have been used for a number of biomaterial applications. Alginate has been used as a scaffolding material for building artificial organs, as a dressing for ulcerous wounds and the targeted delivery of anti-cancer drugs.

User:David Griffin/Sandbox 1

2010-04-30T17:31:30Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:16:35Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:14:57Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:14:14Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:11:03Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:10:37Z

David Griffin:

[[Image:mandg.jpg|frame|Alginate monomers.]]

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate (24,000 Da) ' />

<scene name='User:David_Griffin/Sandbox_1/Alginate_24000da/1'>TextToBeDisplayed</scene>

File:Mandg.jpg

2010-04-30T17:08:36Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T17:00:37Z

David Griffin:

User:David Griffin/Sandbox 1

2010-04-30T15:46:31Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='Sodium Alginate Chain (24,000 Da) ' />

<scene name='User:David_Griffin/Sandbox_1/Alginate_24000da/1'>TextToBeDisplayed</scene>

User:David Griffin/Sandbox 1

2010-04-30T15:45:54Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='24,000 Da Sodium Alginate Chain' />

<scene name='User:David_Griffin/Sandbox_1/Alginate_24000da/1'>TextToBeDisplayed</scene>

User:David Griffin/Sandbox 1

2010-04-30T15:41:53Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='YYY' />

<scene name='User:David_Griffin/Sandbox_1/Alginate_24000da/1'>TextToBeDisplayed</scene>

File:Alginate 24000 Da.pdb

2010-04-30T15:36:54Z

David Griffin:

User:David Griffin/Sandbox 1

2010-03-16T15:12:11Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='YYY' />

<scene name='User:David_Griffin/Sandbox_1/1/1'>TextToBeDisplayed</scene>

<scene name='User:David_Griffin/Sandbox_1/2/1'>TextToBeDisplayed</scene>

<scene name='User:David_Griffin/Sandbox_1/3/1'>TextToBeDisplayed</scene>

User:David Griffin/Sandbox 1

2010-03-16T15:05:23Z

David Griffin:

User:David Griffin/Sandbox 1

2010-03-16T15:04:28Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='YYY' />

<scene name='User:David_Griffin/Sandbox_1/1/1'>TextToBeDisplayed</scene>
<scene name='User:David_Griffin/Sandbox_1/2/1'>TextToBeDisplayed</scene>

User:David Griffin/Sandbox 1

2010-03-16T14:47:31Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='YYY' />

<scene name='User:David_Griffin/Sandbox_1/1/1'>TextToBeDisplayed</scene>

User:David Griffin/Sandbox 1

2010-03-16T14:35:22Z

David Griffin:

<applet size='[450,338]' frame='true' align='right'
caption='YYY' />

----
--[[User:David Griffin|David Griffin]] 16:35, 16 March 2010 (IST)
----

User:David Griffin/Sandbox 1

2010-03-16T14:33:04Z

David Griffin:

User:David Griffin/Sandbox 1

2010-03-16T14:30:14Z

David Griffin: New page: any thing

any thing

User:David Griffin

2010-03-16T12:37:45Z

David Griffin:

David is a Ph.D. candidate in the Bhatia Group at the University of Massachusetts-Amherst in the Chemical Engineering department. Beginning in June of 2009 he was awarded a fellowship in the NIH-Funded CBI (Chemistry/Biology Interface) Program at UMass. David received a B.S. in Chemical Engineering from the University of Kansas in 2005.