Proteopedia - User contributions [en]

https://proteopedia.org/api.php?action=feedcontributions&feedformat=atom&user=Ellie+Siech Proteopedia - User contributions [en] 2026-09-25T12:19:13Z User contributions MediaWiki 1.43.8 https://proteopedia.org/index.php?title=Acetylcholine_Receptor_and_its_Reaction_to_Cobra_Venom&diff=2893178 Acetylcholine Receptor and its Reaction to Cobra Venom 2018-04-30T20:15:26Z

<p>Ellie Siech: New page: ==Acetylcholine receptor and its reaction to cobra venom == <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> ==Structure== The acetylcho...</p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. The cobra toxin is 73 amino acid residues long in a single chain. The cobra toxin changes shape as it binds to the acetylcholine receptor. The blue indicates the amino acids that participate in binding to the receptor. <scene name='77/778333/Cobra_toxin_3/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> Cobra Venom Reactions. (n.d.). Retrieved from http://www.umich.edu/~elements/fogler&gurmen/html/web_mod/cobra/reaction.htm<br /> <br /> B., T., H., T., & M. (n.d.). Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Retrieved from https://www.rcsb.org/structure/1YI5<br /> <br /> Effects of Cobra Venom in Detail. (n.d.). Retrieved from http://www.umich.edu/~elements/5e/web_mod/cobra/venom2.htm<br /> <br /> U., & N. (n.d.). Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution. Retrieved from https://www.rcsb.org/structure/2BG9<br /> <br /> P., K., T., J., C., C., & Y. (n.d.). Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). Retrieved from https://www.rcsb.org/structure/1TXA<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2893158 Sandbox Reserved 1453 2018-04-30T20:06:41Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. The cobra toxin is 73 amino acid residues long in a single chain. The cobra toxin changes shape as it binds to the acetylcholine receptor. The blue indicates the amino acids that participate in binding to the receptor. <scene name='77/778333/Cobra_toxin_3/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> Cobra Venom Reactions. (n.d.). Retrieved from http://www.umich.edu/~elements/fogler&gurmen/html/web_mod/cobra/reaction.htm<br /> <br /> B., T., H., T., & M. (n.d.). Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Retrieved from https://www.rcsb.org/structure/1YI5<br /> <br /> Effects of Cobra Venom in Detail. (n.d.). Retrieved from http://www.umich.edu/~elements/5e/web_mod/cobra/venom2.htm<br /> <br /> U., & N. (n.d.). Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution. Retrieved from https://www.rcsb.org/structure/2BG9<br /> <br /> P., K., T., J., C., C., & Y. (n.d.). Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). Retrieved from https://www.rcsb.org/structure/1TXA<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2893087 Sandbox Reserved 1453 2018-04-30T19:29:41Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. The cobra toxin is 73 amino acid residues long in a single chain. The cobra toxin changes shape as it binds to the acetylcholine receptor. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> Cobra Venom Reactions. (n.d.). Retrieved from http://www.umich.edu/~elements/fogler&gurmen/html/web_mod/cobra/reaction.htm<br /> <br /> B., T., H., T., & M. (n.d.). Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Retrieved from https://www.rcsb.org/structure/1YI5<br /> <br /> Effects of Cobra Venom in Detail. (n.d.). Retrieved from http://www.umich.edu/~elements/5e/web_mod/cobra/venom2.htm<br /> <br /> U., & N. (n.d.). Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution. Retrieved from https://www.rcsb.org/structure/2BG9<br /> <br /> P., K., T., J., C., C., & Y. (n.d.). Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). Retrieved from https://www.rcsb.org/structure/1TXA<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2893065 Sandbox Reserved 1453 2018-04-30T19:13:06Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. The cobra toxin changes shape as it binds to the acetylcholine receptor. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. The second image depicts an individual toxin binding with one chain on the receptor, both in the same color. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>Cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> Cobra Venom Reactions. (n.d.). Retrieved from http://www.umich.edu/~elements/fogler&gurmen/html/web_mod/cobra/reaction.htm<br /> <br /> B., T., H., T., & M. (n.d.). Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Retrieved from https://www.rcsb.org/structure/1YI5<br /> <br /> Effects of Cobra Venom in Detail. (n.d.). Retrieved from http://www.umich.edu/~elements/5e/web_mod/cobra/venom2.htm<br /> <br /> U., & N. (n.d.). Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution. Retrieved from https://www.rcsb.org/structure/2BG9<br /> <br /> P., K., T., J., C., C., & Y. (n.d.). Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). Retrieved from https://www.rcsb.org/structure/1TXA<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889181 Sandbox Reserved 1453 2018-04-20T00:33:56Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> Cobra Venom Reactions. (n.d.). Retrieved from http://www.umich.edu/~elements/fogler&gurmen/html/web_mod/cobra/reaction.htm<br /> <br /> B., T., H., T., & M. (n.d.). Crystal structure of a Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. Retrieved from https://www.rcsb.org/structure/1YI5<br /> <br /> Effects of Cobra Venom in Detail. (n.d.). Retrieved from http://www.umich.edu/~elements/5e/web_mod/cobra/venom2.htm<br /> <br /> U., & N. (n.d.). Refined Structure of the Nicotinic Acetylcholine Receptor at 4A Resolution. Retrieved from https://www.rcsb.org/structure/2BG9<br /> <br /> P., K., T., J., C., C., & Y. (n.d.). Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah). Retrieved from https://www.rcsb.org/structure/1TXA<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889180 Sandbox Reserved 1453 2018-04-20T00:20:09Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> This representation shows each molecule of the <scene name='77/778333/Venom_receptor_piece/1'>cobra toxin binding to one chain of the receptor</scene>. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889179 Sandbox Reserved 1453 2018-04-20T00:15:21Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell.<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. There must be five molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889178 Sandbox Reserved 1453 2018-04-20T00:08:52Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/3'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889163 Sandbox Reserved 1453 2018-04-19T21:08:59Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/6'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889159 Sandbox Reserved 1453 2018-04-19T21:05:51Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <scene name='77/778333/Cobra_toxin/1'>Cobra Toxin</scene><br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889158 Sandbox Reserved 1453 2018-04-19T21:01:05Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. This molecule was generated by overlaying the receptor and venom using Swiss PDB viewer magic fit. The RMS (root mean square difference) of this overlay if 12.21 angstroms involving 185 different atoms. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889157 Sandbox Reserved 1453 2018-04-19T20:51:03Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889156 Sandbox Reserved 1453 2018-04-19T20:50:01Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Venom_Receptor_Overlay.jpg]]<Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889155 Sandbox Reserved 1453 2018-04-19T20:47:31Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Venom_Receptor_Overlay.jpg]]<Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889154 Sandbox Reserved 1453 2018-04-19T20:46:31Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Example.jpg]]<Structure load='Example' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889153 Sandbox Reserved 1453 2018-04-19T20:45:41Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Venom_Receptor_Overlay.jpg]]<Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889152 Sandbox Reserved 1453 2018-04-19T20:45:19Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Venom_Receptor_Overlay.jpg]]<Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=File:Venom_receptor_overlay.pdb&diff=2889150 File:Venom receptor overlay.pdb 2018-04-19T20:42:09Z

<p>Ellie Siech: uploaded a new version of "Image:Venom receptor overlay.pdb"</p> <hr /> <div>== Licensing ==<br /> {{PD-self}}</div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889149 Sandbox Reserved 1453 2018-04-19T20:40:08Z

<p>Ellie Siech: </p> <hr /> <div>[[Image:Venom_Receptor_Overlay.jpg]]<Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=File:Venom_receptor_overlay.pdb&diff=2889119 File:Venom receptor overlay.pdb 2018-04-19T19:52:04Z

<p>Ellie Siech: uploaded a new version of "Image:Venom receptor overlay.pdb"</p> <hr /> <div>== Licensing ==<br /> {{PD-self}}</div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889118 Sandbox Reserved 1453 2018-04-19T19:50:30Z

<p>Ellie Siech: </p> <hr /> <div><Structure load='Venom_receptor_overlay.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=File:Venom_receptor_overlay.pdb&diff=2889117 File:Venom receptor overlay.pdb 2018-04-19T19:46:46Z

<p>Ellie Siech: </p> <hr /> <div>== Licensing ==<br /> {{PD-self}}</div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889114 Sandbox Reserved 1453 2018-04-19T19:28:37Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889110 Sandbox Reserved 1453 2018-04-19T19:25:38Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <scene name='77/778333/Cobra_snake_venom/2'>Text To Be Displayed</scene>{{Sandbox_Reserved_Telford2018}}<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <scene name='77/778333/Cobra_snake_venom/1'>Cobra Venom</scene><br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889108 Sandbox Reserved 1453 2018-04-19T19:22:04Z

<p>Ellie Siech: </p> <hr /> <div>==Acetylcholine receptor and its reaction to cobra venom ==<br /> <scene name='77/778333/Cobra_snake_venom/2'>Text To Be Displayed</scene>{{Sandbox_Reserved_Telford2018}}<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889107 Sandbox Reserved 1453 2018-04-19T19:21:25Z

<p>Ellie Siech: </p> <hr /> <div><br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889105 Sandbox Reserved 1453 2018-04-19T19:19:03Z

<p>Ellie Siech: </p> <hr /> <div><scene name='77/778333/Cobra_snake_venom/2'>Text To Be Displayed</scene>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/2'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889101 Sandbox Reserved 1453 2018-04-19T19:09:59Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> <scene name='77/778333/Cobra_snake_venom/1'>Cobra Venom Interaction with Acetylcholine Receptor</scene><br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889099 Sandbox Reserved 1453 2018-04-19T19:01:31Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine Receptor</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <scene name='77/778333/Cobra_snake_venom/1'>Cobra Venom</scene><br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889098 Sandbox Reserved 1453 2018-04-19T19:00:50Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <scene name='77/778333/Cobra_snake_venom/1'>Cobra Venom</scene><br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889077 Sandbox Reserved 1453 2018-04-19T04:08:58Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <scene name='77/778333/Cobra_venom/1'>Cobra Venom</scene><br /> == Cobra Toxin interaction with Acetylcholine ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2889076 Sandbox Reserved 1453 2018-04-19T04:04:58Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> The acetylcholine receptor is composed of five alpha helical chains each with about 370 amino acids. This is a transmembrane protein forming a funnel into the cytosol of the cell. Alpha and beta receptors<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function as a Signal Molecule Receptor ==<br /> The neurotransmitter acetylcholine is released into the synaptic cleft and is bound to the acetylcholine receptor. Consequently, the receptor changes conformation to release potassium ions into the cytoplasm of the cell while sodium ions are ejected from the cell through the receptor acting as an ion-gated channel. This change in ion concentration causes a change in the membrane potential of the cell. The release of sodium into extracellular matrix causes a release of more acetylcholine in a neighboring cell continuing the action potential across nerve cells. Nerve cell communication is also in control of muscle contraction. When the action potential traveling down the nerve cell reaches muscle tissue, the muscle cell responds by triggering a release in calcium to allow for muscle contraction for the organism to move.<br /> == Cobra Toxin ==<br /> Cobra venom has several detrimental effects on their prey. This toxin blocks the acetylcholine receptor which causes paralysis of the muscles, including the diaphragm which leads to asphyxiation. Only about 1/3 of the acetylcholine receptors need to be blocked to cease function of the diaphragm resulting in death in as little as thirty minutes. <br /> <scene name='77/778333/Cobra_venom/1'>Cobra Venom</scene><br /> == Cobra Toxin interaction with Acetyl Choline ==<br /> When cobra venom is introduced into the body is moves along the bloodstream to a diaphragm muscle. It works as a postsynaptic neurotoxin by interacting with OH group leaving the acetyl choline channel open which releases ions used in creating an action potential. Without the ions the diaphragm muscle can not be activated to contract and will not move so an individual can not take a breath. <br /> == Anti-Venom ==<br /> There are only two ways to save a life after being infected with cobra venom the first being an artificial respirator to contract and expand the lungs until the diaphragm is able to start an action potential and contract on its own. The other option to a quick administration of an anti-venom. Anti-venom acts to bind the venom both in the receptor and in the bloodstream and allows for it to be excreted out of the body.<br /> <br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2885549 Sandbox Reserved 1453 2018-04-12T18:12:10Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function ==<br /> <br /> == Response to Cobra Venom ==<br /> <scene name='77/778333/Cobra_venom/1'>Cobra Venom</scene><br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2885538 Sandbox Reserved 1453 2018-04-12T00:13:06Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Acetylcholine receptor and its reaction to cobra venom ==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function ==<br /> <br /> == Disease ==<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2885425 Sandbox Reserved 1453 2018-04-11T19:29:15Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Your Heading Here (maybe something like 'Structure')==<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.<br /> You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.<br /> ==Structure==<br /> <scene name='77/778333/Acetylcholine/5'>Acetylcholine</scene><br /> <br /> == Function ==<br /> <br /> == Disease ==<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2885418 Sandbox Reserved 1453 2018-04-11T19:25:45Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Structure==<br /> <scene name='77/778333/Acetylcholine/4'>Acetylcholine</scene><br /> == Function ==<br /> <br /> == Disease ==<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1453&diff=2885413 Sandbox Reserved 1453 2018-04-11T19:20:41Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> ==Structure==<br /> <scene name='77/778333/Acetylcholine/1'>Acetylcholine</scene><br /> == Function ==<br /> <br /> == Disease ==<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1446&diff=2885411 Sandbox Reserved 1446 2018-04-11T19:15:24Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> Uricase<br /> <StructureSection load='4ej4' size='340' side='right' caption='Caption for this structure' scene=''><br /> <br /> <br /> Uricase is an enzyme that catalyzes the conversion or uric acid to allantoin. Uric acid is<br /> an acidic waste product that your body passes through urine. It is a normal byproduct of the<br /> breakdown of foods that contain purines. Normally, the kidneys filter out uric acid from your<br /> blood; if too much builds up, it can lower the pH of your blood and urine and lead to a painful<br /> joint condition called gout and other complications. The reason I chose uricase is because it<br /> monitors the uric acid levels in our body. Interestingly, humans have naturally selected to<br /> terminate uricase. Because of the absence of uricase in humans, we may go through many<br /> complications caused by uric acid build up. Scientists are studying why natural selection would<br /> allow the accumulation of uric acid even though there are psychological complications of<br /> crystalized monosodium urate acutely causing liver and kidney damage or chronically causing<br /> gout.<br /> ==Structure==<br /> <scene name='77/778326/Acetylcholine_receptor/1'>Acetylcholine Structure</scene><br /> <br /> == Function ==<br /> <br /> == Disease ==<br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech https://proteopedia.org/index.php?title=Sandbox_Reserved_1446&diff=2885407 Sandbox Reserved 1446 2018-04-11T19:05:37Z

<p>Ellie Siech: </p> <hr /> <div>{{Sandbox_Reserved_Telford2018}}<br /> Uricase<br /> <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''><br /> <br /> <br /> Uricase is an enzyme that catalyzes the conversion or uric acid to allantoin. Uric acid is<br /> an acidic waste product that your body passes through urine. It is a normal byproduct of the<br /> breakdown of foods that contain purines. Normally, the kidneys filter out uric acid from your<br /> blood; if too much builds up, it can lower the pH of your blood and urine and lead to a painful<br /> joint condition called gout and other complications. The reason I chose uricase is because it<br /> monitors the uric acid levels in our body. Interestingly, humans have naturally selected to<br /> terminate uricase. Because of the absence of uricase in humans, we may go through many<br /> complications caused by uric acid build up. Scientists are studying why natural selection would<br /> allow the accumulation of uric acid even though there are psychological complications of<br /> crystalized monosodium urate acutely causing liver and kidney damage or chronically causing<br /> gout.<br /> <br /> == Function ==<br /> <Structure load='4EJ4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><br /> == Disease ==<br /> test <scene name='77/778326/Bad_one/1'>scene</scene><br /> <br /> == Relevance ==<br /> <br /> == Structural highlights ==<br /> <br /> This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.<br /> <br /> </StructureSection><br /> == References ==<br /> <references/></div>

Ellie Siech