Proteopedia - User contributions [en]

CBI Molecules

2011-05-04T18:30:08Z

Erika M. Saffer:

These are molecules under study by members of the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program].
Many of the molecules we study are featured at the [http://www.molecularplayground.org/ Molecular Playground]. Follow the links below to read nontechnical descriptions in Proteopedia.

UMass CBI Members, add your molecules to the list (which is alphabetical by CBI research mentor); follow the instructions below the list.

It's great to build on a previous entry, but you must leave the earlier one intact and make a copy that you improve and mark as new. Later we will retain the new one with a merged author list.

Fall 2010: New entries are due 12/10/10. Please append the designation (new Fall 2010) to your new entries.

Spring 2011: New entries are due 5/4/11. Please append the designation (new Spring 2011) to your new entries

Bhatia Lab
: '''[[Molecular Playground/Alginate]]''', David Griffin

: '''[[Molecular Playground/Alginate-Fall2010]]''', Joe White, David Griffin (new Fall 2010)

: '''[[Molecular Playground/Poly(ethylene glycol)]]''', Erika M. Saffer (new Spring 2011)

[http://chamberslab.com/wp/ Chambers Lab]

: '''[[Molecular Playground/Glutamate Receptor]]''', Amanda Hussey, Steve McCarron, Rosie Combs-Bachmann, Mariel Feliciano

[http://openwetware.org/wiki/Chien Chien Lab]

: '''[[Molecular Playground/Hexameric ClpX]]''', Joanne Lau (new Fall 2010)

Forbes Lab

: '''[[Molecular Playground/TRAIL]]''', Charley Swofford

: '''[[Molecular Playground/CheR]]''', Miaomin Zhang (new Spring 2011)

[http://www.biochem.umass.edu/garman/index.html Garman Lab]

: '''[[Molecular Playground/Human Protective Protein Cathepsin A]]''', Yadilette Rivera-Colon

: '''[[Molecular Playground/Human PPCA]]''', Nilima Kolli

[http://people.chem.umass.edu/gieraschlab/ Gierasch Lab]

: '''[[CRABP I ( Cellular Retinoic Acid Binding Protein )|Molecular Playground/CRABP I]]''', Kristine Faye Pobre, Mylene Ferrolino,Mangai Periasamy
:: Best Overall CBI Molecule 2010

[http://people.chem.umass.edu/jhardy/ Hardy Lab]

: '''[[Molecular Playground/Caspase-7 Dynamics]]'''

: '''[[Molecular Playground/Caspase-9 Regulation]]''', Kristen Huber

: '''[[Molecular Playground/Caspase-6 (new)]]''', Elih Velazquez

: '''[[Molecular Playground/Influenza A M2 transmembrane domain]]''', Samantha Nicholls

: '''[[Molecular Playground/Dengue Virus Protease]]''', Muslum Yildiz

Hebert Lab

: '''[[Molecular_Playground/ERMan1]]''', Johan Sunryd

[http://people.biochem.umass.edu/aheuck/aph.html Heuck Lab]

: '''[[Molecular_Playground/Pcr H]]''', Fabian Romano (new Fall 2011)

Kaltashov Lab

: '''[[Molecular Playground/Velaglucerase]]''', Adriana Kita

Knapp lab

:'''[[Molecular Playground/Prolyl Hydroxylase Domain (PHD) Enzyme]]''', Cristina Martin
:: Best CBI Molecule Proteopedia Page 2010

: '''[[Molecular Playground/FIH]]''', Cornelius Taabazuing, Breanne Holmes, John Hangasky

[http://www.chem.umass.edu/~cmartin/ Martin Lab]

: '''[[Molecular Playground/T7 RNA Polymerase (7 mer int)]]''', Ankit Vahia
: '''[[Molecular Playground/T7 RNAP Conformations]]''', Luis E. Ramirez-Tapia (new Fall 2010)

[http://robertsgroup.ecs.umass.edu/ Roberts Lab]

: '''[[Molecular Playground/Taxol]]''', Rohan Patil, Sarah Wilson

: '''[[Molecular Playground/Insulin]]''', Whitney Stoppel

[http://www.umass.edu/rotellogroup/ Rotello Lab]

: '''[[Reverse transcriptase|Molecular Playground/Reverse Transcriptase]]''', Daniel Moyano-Marino

: '''[[Molecular Playground/Pancreatic Lipase]]''', Rui Tang

: '''[[Molecular playground/Chymotrypsin]]''', Brad

: '''[[Molecular Playground/Targeting Peptide]]''', David Solfiell

Schnarr Lab

: '''[[6-deoxyerythronolide_B_synthase_(DEBS)|Molecular Playground/6-Deoxyerythronolide B Synthase]]''', Tsung-Yi Lin, Jon Amoroso

: '''[[Molecular Playground/ACP apo]]''', Gitanjeli Prasad

Thayumanavan Lab

: '''[[Molecular Playground/Lysozime ]]''', Daniella Gonzalez

: '''[[Molecular Playground/Beta-galactosidase]]''', Judy Ventura

: '''[[User:Krishna Reddy Ragupathi|Molecular Playground/Carbonic Anhydrase]]''', Krishna Reddy Raghupathi

: '''[[User:Rami Rajasekhar Reddy|Molecular Playground/Avidin]]''', Rami Rajasekar Reddy

: '''[[Molecular Playground/Biotin binding avidin]]''', Diego Amado

: '''[[User:Jiaming Zhuang|Molecular Playground/MMP12]]''', Jiaming Zhuang

: ''' [[User:Jing Guo|Molecular Playground/Gluconase]]''', Jing Guo

: '''[[Molecular Playground/Glutathione Reductase]]''', Reuben Chacko

Thayumanavan & Vachet Labs

: '''[[Molecular Playground/Trypsin]]''', Gladys Murage

[http://people.chem.umass.edu/thompson/index.html Thompson] & [http://www.chem.umass.edu/~rmweis/weislab/ Weis] Labs

: '''[[Molecular Playground/Bacterial Chemotaxis Receptors]]''', Lynmarie K. Thompson, Shiela M. Jones

: '''[[Molecular Playground/cytoplasmic domain of a serine chemotaxis receptor]]''', Meili Yang

[http://www.chem.umass.edu/~vachet/index.html Vachet Lab]

: '''[[Molecular playground/beta 2 microglobulin]]''', Nick Borotto
:: Best CBI Molecule Jmol scenes 2010

: '''[[Molecular Playground/Myoglobin]]''', Yuping Zhou

:'''[[Molecular Playground/ Copper-Zinc Superoxide Dismutase]]''', Shaynah Browne (NEW FALL 2010)

Other Molecules of interest

: '''[[Molecular Playground/PcrA Helicase]]''', Luis E Ramirez-Tapia, [http://www.chem.umass.edu/~cmartin/ Martin Lab]

Other Laboratories

: '''[[Molecular Playground/YKL-40]]''', Ralph A. Francescone III, [http://www.bio.umass.edu/mcb/faculty/Shao.html Shao Lab]

: '''[[Molecular Playground/BLG|Molecular Playground/β-lactoglobulin]]''', Daniel Seeman, Dubin Lab

: '''[[Molecular Playground/ADAM13]]''', Genevieve Abbruzzese, Alfandari Lab

Instructions:

'''Congratulations to the prize-winning CBI molecules noted above! These also provide great examples to follow. Another prize for best CBI Molecules page and/or scene will be awarded in spring 2011!'''

Choose a molecule that is part of your research project.

1. If you don't already have one, request a Proteopedia account and log in. If you are new to Proteopedia, click Help in the navigation box on the left to get started.

2. Make yourself a sandbox page in which you will develop your CBI Molecule scene and description (Enter "User:your name/sandbox 1" (omit quotes) in the search box, then follow instructions to edit this page. See example [[User:Lynmarie K Thompson/Sandbox 1]]).

3. Follow the format of the sample CBI molecule page [[Molecular Playground/Bacterial Chemotaxis Receptors]]. Easiest way to do this is to copy this page (in editing mode), paste it into your sandbox page, keep the first paragraph about CBI molecules, and then edit to describe and display your molecule. Your goal is to make this an interesting, nontechnical description of the molecule. If multiple people in one group work on the same molecule, you can each make different scenes for the same CBI molecule and each describe them on the same proteopedia page. Talk with each other about your plans so you are not duplicating efforts.

4. Create an attractive scene for your molecule: use the scene authoring tools in the edit mode to create the view you like, then copy the wiki text into your window.

5. Choose a "green scene" on your Proteopedia page to suggest for display at the Molecular Playground and specify a "banner" which will be projected with the molecule. This should be a short, one-line headline for your scene that includes the name of the molecule and what is important about the scene or the molecule. Remember to design this for the general public, including non-scientists. My example is: "Molecular Playground banner: A bacterial chemotaxis receptor protein used by bacteria to "smell" their environment."

6. When you are happy with your sandbox page, make yourself a permanent Proteopedia page, which will be editable by others. Enter "Molecular Playground/your molecule" (omit quotes) in the search box, then follow the instructions to create a new page with this title. Copy the content of your sandbox to this new page.

7. When you have finished the final version of your page and scene, edit this CBI Molecules page to add a listing and link for your molecule, following the "Bacterial chemotaxis receptors" example above. Please list your lab group, with your name in parentheses. That way more than one name can be associated with a Molecular Playground page (if there are several students on the Molecular Playground page, please indicate your scene with your initials). It would be great to link the lab names to web pages too.

Molecular Playground/Poly(ethylene glycol)

2011-05-04T18:26:05Z

Erika M. Saffer: New page: One of the CBI Molecules being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at th...

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW), PDB files obtained from HIC-UP, http://xray.bmc.uu.se/hicup/
' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T18:18:46Z

Erika M. Saffer:

Erika M. Saffer/sandbox1

2011-05-04T18:08:00Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW), PDB file obtained from HIC-UP, http://xray.bmc.uu.se/hicup/
' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T18:03:31Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW)' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

NOTE: PDB files obtained from Hetero-compound Information Centre-Uppsala (HIC-UP), http://xray.bmc.uu.se/hicup/

Erika M. Saffer/sandbox1

2011-05-04T18:01:22Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW), PDB files obtained from Hetero-compound Information Centre-Uppsala (HIC-UP), http://xray.bmc.uu.se/hicup/' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T18:00:37Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW), PDB files obtained from Hetero-compound Information Centre-Uppsala (HIC-UP), <http://xray.bmc.uu.se/hicup/>' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:36:12Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW)' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:33:56Z

Erika M. Saffer:

<applet size='[450,355]' frame='true' align='right'
caption='Poly(ethylene glycol) (400 MW)' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'/>

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:30:20Z

Erika M. Saffer:

<applet size='[450,350]' frame='true' align='right'
caption='Poly(ethylene glycol), MW 400' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/2'>

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:29:27Z

Erika M. Saffer:

<applet size='[450,350]' frame='true' align='right'
caption='Poly(ethylene glycol), MW 400' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/1'/>

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:27:43Z

Erika M. Saffer:

<applet size='[450,350]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:26:39Z

Erika M. Saffer:

<applet size='[450,338]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/2'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:24:00Z

Erika M. Saffer:

<applet size='[450,338]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:'Erika_M._Saffer/sandbox1/Peg_400mw/1'>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Peg_400mw/1'>polymer</scene>. The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:19:56Z

Erika M. Saffer:

<applet size='[450,500]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Peg_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'>polymer</scene>.The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:09:28Z

Erika M. Saffer:

<applet size='[450,500]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:Erika M. Saffer/sandbox1/Poly_ethylene_glycol/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Ethylene_glycol_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'>polymer</scene>.The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T17:08:44Z

Erika M. Saffer:

<applet size='[600,338]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:Erika M. Saffer/sandbox1/Poly_ethylene_glycol/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Ethylene_glycol_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'>polymer</scene>.The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

Erika M. Saffer/sandbox1

2011-05-04T16:39:16Z

Erika M. Saffer:

<applet size='[450,338]' frame='true' align='right'
<caption='Poly(ethylene glycol), MW 400' scene='User:Erika M. Saffer/sandbox1/Poly_ethylene_glycol/1'/>
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Ethylene_glycol_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'>polymer</scene>.The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

When PEG is crosslinked with a hydrophobic polymer, it will self assemble into micellular structures when in aqueous solution. Micelles can be used for drug encapsulation as well as for drug delivery vehicles.

Erika M. Saffer/sandbox1

2011-05-04T16:34:28Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its <scene name='Erika_M._Saffer/sandbox1/Ethylene_glycol_monomer/1'>monomer</scene>, ethylene glycol (C2H6O2). During polymerization, the ethylene glycol monomers chemically link together to form a long chain, referred to as a <scene name='Erika_M._Saffer/sandbox1/Poly_ethylene_glycol/1'>polymer</scene>.The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

When PEG is crosslinked with a hydrophobic polymer, it will self assemble into micellular structures when in aqueous solution. Micelles can be used for drug encapsulation as well as for drug delivery vehicles.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

File:P6g msd.pdb

2011-05-04T16:18:14Z

Erika M. Saffer:

Erika M. Saffer/sandbox1

2011-05-04T16:15:47Z

Erika M. Saffer:

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide)(PEO), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its monomer, ethylene glycol (C2H6O2)<scene name='Erika_M._Saffer/sandbox1/Ethylene_glycol_monomer/1'>TextToBeDisplayed</scene>. During polymerization, the ethylene glycol monomers become chemically linked together, forming a long chain (polymer). The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

When PEG is crosslinked with a hydrophobic polymer, it will self assemble into micellular structures when in aqueous solution. Micelles can be used for drug encapsulation as well as for drug delivery vehicles.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

File:Edo clean.pdb

2011-05-04T16:03:54Z

Erika M. Saffer:

File:Edo exp.pdb

2011-05-04T16:01:14Z

Erika M. Saffer:

File:Edo msd.pdb

2011-05-04T15:53:06Z

Erika M. Saffer:

Erika M. Saffer/sandbox1

2011-05-04T15:50:13Z

One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].

Poly(ethylene glycol) (PEG), also referred to as poly(ethylene oxide), is a synthetic, hydrophilic polymer. Due to its unique physical and chemical properties, it has found use in a wide range of applications from industrial manufacturing processes to pharmaceutical formulations. In recent year, PEG has been investigated for use as tissue engineering scaffolds, biocompatible hydrogels, and as drug delivery vehicles.

PEG is formed from several repeating units of its monomer, ethylene glycol. During polymerization, the ethylene glycol monomers become chemically linked together, forming a long chain (polymer). The polymerization process can be controlled, allowing for the formation of a wide range of molecular weights. PEG is biocompatible at low molecular weights. When these polymers are end functionalized, they can crosslink with one another and form a network. Due to the hydrophilic nature of PEG, when this network is in the presence of water it will swell to form a hydrogel. The physical properties of these hydrogels make them excellent candidates for use as tissue engineering scaffolds and in other biomaterial applications.

When PEG is crosslinked with a hydrophobic polymer, it will self assemble into micellular structures when in aqueous solution. Micelles can be used for drug encapsulation as well as for drug delivery vehicles.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

User:Erika M. Saffer

2011-05-04T15:45:23Z

Erika M. Saffer:

I am currently a PhD candidate in Chemical Engineering at the University of Massachusetts Amherst. My thesis research involves the characeterization of PEG-based hydrogels for biomaterial and tissue engineering applications.
*[[Erika M. Saffer/sandbox1]]

User:Erika M. Saffer

2011-05-04T15:43:37Z

Erika M. Saffer: