Proteopedia - User contributions [en]

Tdp-43

2018-03-17T21:36:06Z

Gerry Lushington:

TDP-43 helical stabilizers
<StructureSection load='2n2cligalza0.pdb.gz' size='350' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037571/)' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils.

== Function ==

'''Tdp-43''' or '''TAR DNA-binding protein 43''' is a heterogeneous nuclear ribonucleoprotein which has crucial roles in gene expression and alternative splicing, stress response, neuronal functions such as neurite outgrowth and many other cellular processes<ref>PMID:17981595</ref>.

== Disease ==

Tdp-43 mutations were found ion familial and sporadic ALS patients<ref>PMID:18309045</ref>. Phosphorylated Tdp-43 is deposited as cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration and ALS<ref>PMID:18546284</ref>.

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein.
</StructureSection>

== 3D Structures of Tdp-43 ==

Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

[[2cqg]] – hTDP-43 RRM1 domain – human - NMR 
[[1wf0]] – hTDP-43 RRM2 domain - NMR 
[[5mrg]], [[2n4p]], [[5x4f]] – hTDP-43 N-terminal domain - NMR 
[[5mdi]] – hTDP-43 N-terminal domain 
[[2n2c]], [[2n3x]] – hTDP-43 prion-like helix - NMR 
[[2n4g]], [[2n4h]] – hTDP-43 prion-like helix (mutant) - NMR 
[[4y0f]], [[4iuf]] – hTDP-43 RRM1 domain + DNA 
[[4y00]] – hTDP-43 RRM1 domain (mutant) + DNA 
[[4bs2]] – hTDP-43 RRM1+RRM2 domains + RNA - NMR 
[[3d2w]] – TDP-43 RRM2 domain + DNA - mouse 

== References ==
<references/>

Tdp-43

2016-03-03T16:05:30Z

Gerry Lushington:

TDP-43 helical stabilizers
<StructureSection load='2n2cligalza0.pdb.gz' size='600' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T15:07:36Z

Gerry Lushington:

TDP-43 helical stabilizers
<StructureSection load='2n2cligalza0.pdb.gz' size='340' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

File:2n2cligalza0.pdb.gz

2016-03-03T15:06:51Z

Gerry Lushington: Compound A is the best current binder to the healthy helical tdp-43

Compound A is the best current binder to the healthy helical tdp-43

Tdp-43

2016-03-03T14:57:42Z

Gerry Lushington:

TDP-43 helical stabilizers
<StructureSection load='2n2c_ligalza0.pdb' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T14:57:05Z

Gerry Lushington:

TDP-43 helical stabilizers
<StructureSection load='2n2c_ligalza0.pdb.gz' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T14:52:40Z

Gerry Lushington:

<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />TDP-43 helical stabilizers
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T14:52:05Z

Gerry Lushington:

<Structure load='2n2c_ligalza0.pdb.gz' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />TDP-43 helical stabilizers
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

File:2n2c ligalza0.pdb.gz

2016-03-03T14:51:32Z

Gerry Lushington: (Compound A is the best current binder to the healthy helical tdp-43)

(Compound A is the best current binder to the healthy helical tdp-43)

Tdp-43

2016-03-03T14:30:57Z

Gerry Lushington:

<Structure load='2n2c_ligalza0' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />TDP-43 helical stabilizers
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T14:29:09Z

Gerry Lushington:

<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />TDP-43 helical stabilizers
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils.<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T14:28:08Z

Gerry Lushington:

<Structure load='http://proteopedia.org/wiki/index.php/Image:2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />TDP-43 helical stabilizers
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils.<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T13:39:22Z

Gerry Lushington:

<Structure load='http://proteopedia.org/wiki/index.php/Image:2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils.<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Tdp-43

2016-03-03T13:37:09Z

Gerry Lushington: New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is the healthy helical co...

==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils.<Structure load='2n2c_ligalza0.pdb' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> '''Tdp-43'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

File:2n2c ligalza0.pdb

2016-03-02T15:12:41Z

Gerry Lushington: Compound A is the best current binder to the healthy helical tdp-43

Compound A is the best current binder to the healthy helical tdp-43