Proteopedia - User contributions [en]

User:Gisselle Medina/Sandbox7 Leader

2016-03-02T16:57:39Z

Gisselle Medina: /* Structure */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.

==Structure==
FMDV Lpro is composed of two secondary structures:
<scene name='48/484916/Alpha_helix/1'>alpha-helix</scene> and <scene name='48/484916/Beta_sheet/1'>beta-sheet</scene>.
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>

==Structure==
FMDV Lpro is composed of two secondary structures: alpha-helix and beta sheet. Just like other papain-like cysteine proteases, Lpro catalytic site is composed of the triad Cys/His/Asn.

==Structure==
Lpro is composed of two secondary structures: a-helix and beta sheet.

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T19:44:43Z

Gisselle Medina: /* Introduction */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.

==Structure==
FMDV Lpro is composed of two secondary structures: alpha-helix and beta-sheet.
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>

==Structure==
FMDV Lpro is composed of two secondary structures: alpha-helix and beta sheet. Just like other papain-like cysteine proteases, Lpro catalytic site is composed of the triad Cys/His/Asn.

==Structure==
Lpro is composed of two secondary structures: a-helix and beta sheet.

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T19:32:14Z

Gisselle Medina: /* Introduction */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>

==Structure==
FMDV Lpro is composed of two secondary structures: alpha-helix and beta sheet. Just like other papain-like cysteine proteases, Lpro catalytic site is composed of the triad Cys/His/Asn.

==Structure==
Lpro is composed of two secondary structures: a-helix and beta sheet.

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T16:30:08Z

Gisselle Medina: /* Introduction */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>
==Structure==
Lpro is composed of two secondary structures: a-helix and beta sheet.

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T16:28:35Z

Gisselle Medina: /* Introduction */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain.It is known to block different cellular functions by different mechanisms. One of the most characterized cellular targets of Lpro is the cellular protein eukaryotic initiation factor 4G (eIF4G). During infection Lpro cleaves the translation factor eIF4G blocking the synthesis of cellular proteins. This provides a mechanism that favors viral translation.
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T15:52:22Z

Gisselle Medina: /* Introduction */

==Introduction==
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV). It is the first protein to be translated and cleaves itself from the nascent viral polyprotein chain. This protease. It is known to inhibit interferon responses by different cellular mechanisms. It is the first protein to be translated from the polyprotein
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:49:59Z

Gisselle Medina: /* Introduction */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'>
Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV).

==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:20:28Z

Gisselle Medina: /* Introduction */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'
==Structure==

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:18:29Z

Gisselle Medina: /* Introduction */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='48/484916/Starting_molecule/4'>Lb</scene'

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:12:00Z

Gisselle Medina: /* Introduction */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:07:16Z

Gisselle Medina: /* Introduction */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />

<scene name='48/484916/Starting_molecule/4'>TextToBeDisplayed</scene>

==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-29T14:03:36Z

Gisselle Medina: /* Structure */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-28T17:20:03Z

Gisselle Medina: /* Structure */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2016-02-28T17:18:50Z

Gisselle Medina: /* Structure */

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein (Lpro</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina

2016-02-28T16:31:13Z

Gisselle Medina:

I am research microbiologist at USDA/ARS in Plum Island Animal Disease Center. My field of study is to understand foot-and-mouth virus (FMDV)-host interactions. Specifically I study the role of the protease Leader during virus replication.
I also have worked in the Department of Molecular Genetics and Microbiology as well as in the Undergraduate Biology Department at Stony Brook University. There, my research focused on the study of HIV, specifically I studied the different mechanisms and pathways that the virus utilizes to successfully exit the cell for further rounds of infection.
Also, I have taught a research course for undergraduates students whose majors are in Biochemistry and Biology. This idea has come from the outreach program called SMART team offered to high school students (MSOE).
The objectives for this course are to provide the students with a portfolio that will increase their chances of getting into a research lab in such a large institution. The course offers basic knowledge of protein biochemistry and structural biology through lectures, journal clubs and usage of computer softwares that allows the visualization of molecules in 3D (RasMol). Students then joined a research lab for couple of weeks where they model a protein of interest as indicated by the principal investigator. The final model of a protein is then printed in a rapid prototyping facility where critical information can be obtained when a physical model is observed. We are hopeful that this course will serve as a filter apparatus for Faculty members when selecting undergraduate students for research projects.

*[[User:Gisselle Medina/Sandbox1 Carbonic Anhydrase]]
*[[User:Gisselle Medina/Sandbox2 Rhodopsin]]
*[[User:Gisselle Medina/Sandbox3 Glucosamine 6 Phosphate Synthase]]
*[[User:Gisselle Medina/Sandbox4 Interconnected Network of Cellular Proteins and Retroviruses]]
*[[User:Gisselle Medina/Sandbox5 Rhodopsin]]
*[[User:Gisselle Medina/Sandbox6 HIV and Tsg101]]
*[[User:Gisselle Medina/Sandbox7 Leader]]

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:25:13Z

Gisselle Medina:

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
==Structure==
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:22:13Z

Gisselle Medina:

==Introduction==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
==Structure==
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:20:18Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro'scene='48/484916/Starting_molecule/3'>TextToBeDisplayed</scene'>
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:17:33Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here'>__NOTOC__
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:14:39Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:13:26Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='550' frame='true' align='right' caption='Insert caption here' background= 'black' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:12:58Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='485' frame='true' align='right' caption='Insert caption here' background= 'black' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:12:27Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='350' frame='true' align='right' caption='Insert caption here' background= 'black' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T19:10:59Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Leader' scene='<scene name='48/484916/Starting_molecule/3'/scene>' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T18:05:03Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Leader' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T18:04:12Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='350' frame='true' align='right' caption='FMDV Leader' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T17:34:59Z

Gisselle Medina:

==Introduction==

==Structure==
<Structure load='2JQG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T12:58:52Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T12:58:01Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
The <scene name='48/484916/Starting_molecule/1'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right.

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T12:09:34Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='FMDV Lpro' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right

User:Gisselle Medina/Sandbox7 Leader

2014-05-17T11:56:36Z

Gisselle Medina:

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T18:52:53Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='FMDV Lpro' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
an α-helical<scene name='48/484916/Alpha_helix/1'>TextToBeDisplayed</scene> domain on the left and a predominantly β-sheet domain on the right

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T16:44:00Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='FMDV Lpro' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>.
an α-helical domain on the left and a predominantly β-sheet domain on the right

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T15:29:42Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='FMDV Lpro' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>
an α-helical domain on the left and a predominantly β-sheet domain on the right

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T15:28:55Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>
an α-helical domain on the left and a predominantly β-sheet domain on the right
<Structure load='2JQG' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T15:22:50Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>
an α-helical domain on the left and a predominantly β-sheet domain on the right

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T14:54:54Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

User:Gisselle Medina/Sandbox7 Leader

2014-05-16T14:52:51Z

Gisselle Medina: /* Structure */

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
The leader protein from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> which contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

User:Gisselle Medina/Sandbox7 Leader

2012-05-07T02:52:08Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> which contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

User:Gisselle Medina/Sandbox7 Leader

2012-05-06T21:29:13Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> which contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

<Structure load='1PY9' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T20:50:09Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> which contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T19:12:01Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site. <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T19:02:06Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> contributes to self-processing.
CTE is composed of 18 amino acid residues and presumably can fold back into its own active site.

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:56:51Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==

==Structure==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> contributes to this self-processing. CTE is composed of 18 amino acid residues and presumably it can fold back into its own active site.

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:56:09Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==
<Structure load='2JQG' size='400' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> contributes to this self-processing. CTE is composed of 18 amino acid residues and presumably it can fold back into its own active site.

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:55:06Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==
<Structure load='2JQG' size='500' frame='true' align='right' caption='Insert caption here' scene='Leader Protease' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> contributes to this self-processing. CTE is composed of 18 amino acid residues and presumably it can fold back into its own active site.

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:47:57Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==
<Structure load='2JQG' size='500' frame='true' align='right' caption='Insert caption here' scene='Leader Protease' />
Lpro upon translation frees itself from the growing polypeptide. This self-processing event is believed to occurred intramolecularly. A flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/1'>C-terminal extension (CTE)</scene> contributes to this self-processing. CTE is composed of 18 amino acid residues and presumably it can fold back into its own active site.

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:34:46Z

Gisselle Medina:

User:Gisselle Medina/Sandbox7 Leader

2012-05-04T18:33:28Z

Gisselle Medina:

[[Image:Leader 1QMY.jpg|left|300px]]
==Introduction==
<scene name='User:Gisselle_Medina/Sandbox7_Leader/2_structure/1'>secondary structure </scene>
<scene name='User:Gisselle_Medina/Sandbox7_Leader/2_structure/2'>alpha helices and beta sheets</scene>

<Structure load='1QMY' size='500' frame='true' align='right' caption='FMDV Leader Protease' scene='Insert optional scene name here' />

<scene name='User:Gisselle_Medina/Sandbox7_Leader/His48_leader/1'>HIS48</scene>

<Structure load='2JQG' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
<scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/1'>C-terminal extension (CTE)</scene>

User:Gisselle Medina/Sandbox7 Leader

2012-03-27T22:50:47Z

Gisselle Medina: