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2026-09-16T18:30:32Z
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https://proteopedia.org/index.php?title=Elastase&diff=1243862
Elastase
2011-05-15T11:13:31Z
<p>Guido Hansen: </p>
<hr />
<div>[[Image:3ba0.png|left|200px|thumb|Crystal structure of full-length human Elastase (Metalloproteinase-12), [[3ba0]]]]<br />
{{STRUCTURE_3ba0| PDB=3ba0 | SIZE=300| SCENE=Elastase/Cv/2 |right|CAPTION=Human Elastase (Metalloproteinase-12), [[3ba0]] }}<br />
<br />
[[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative elastase structure, ''i.e.'' the human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA ([[3ba0]]). Calcium ions are shown as green balls, zinc ions are grey balls and acetohydroxamic acid is shown as space filling object. <br />
<br />
{{TOC limit|limit=2}}<br />
<br />
<br />
== MMP12 ==<br />
<br />
<br />
[[3lka]] - hMMP12 catalytic domain+hydroxamic acid+paramethoxy-sulfonyl amide – human<br /><br />
[[3ba0]], [[1jk3]] – hMMP12<br /><br />
[[3ehx]], [[3ehy]], [[1utt]], [[1utz]], [[1ros]] - hMMP12 catalytic domain+inhibitor<br /><br />
[[2oxu]] - hMMP12 catalytic domain<br /><br />
[[2oxw]], [[2oxz]] - hMMP12 catalytic domain+peptide<br /><br />
[[2hu6]] - hMMP12 catalytic domain+bicyclic inhibitor<br /><br />
[[1rmz]] - hMMP12 catalytic domain+ inhibitor NNGH<br /><br />
[[1y93]] - hMMP12 catalytic domain+acetohydroxamic acid<br /><br />
[[1jiz]] – hMMP12+ hydroxamic acid<br /><br />
[[1os2]] - hMMP12 (mutant)+hydroxamic acid<br /><br />
[[1os9]] - hMMP12 (mutant)<br /><br />
[[3f15]], [[3f16]], [[3f17]], [[3f18]], [[3f19]], [[3f1a]] - hMMP12 catalytic domain+sulfonamide inhibitor<br /><br />
[[2w0d]] - hMMP12 catalytic domain (mutant)<br /><br />
[[2krj]], [[2k9c]] – hMMP12 fraction – NMR<br /><br />
[[2jxy]] - hMMP12 hemopexin-like domain – NMR<br /><br />
[[2k2g]] - hMMP12 catalytic domain+inhibitor – NMR<br /><br />
[[2poj]] - hMMP12 catalytic domain – NMR<br /><br />
[[2z2d]] - hMMP12 catalytic domain+butanoic acid – NMR<br /><br />
[[1ycm]], [[1z3j]] – hMMP12 (mutant)+hydroxamic acid derivative - NMR<br /><br />
[[3lk8]] - hMMP12 catalytic domain (mutant)+hydroxamic acid derivative<br /><br />
[[2wo8]], [[2wo9]], [[2woa]] – hMMP12 fraction+hydroxy carboxylic acid<br /><br />
[[3lik]], [[3lil]], [[3lir]], [[3ljg]] – hMMP12 catalytic domain (mutant)+chelating inhibitor<br />
<br />
== MMP16 ==<br />
<br />
<br />
[[1rm8]] – hMMP16+batimastat<br />
<br />
<br />
== ELA ==<br />
<br />
<br />
[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]] – pELA1 – pig<br /><br />
[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br /><br />
[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br /><br />
[[1fzz]] – pELA1+ONO-6818<br /><br />
[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br /><br />
[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br /><br />
[[1eai]] – pELA1+Ascaris inhibitor<br /><br />
[[2d26]] – pELA1+α-1-antitrypsin<br /><br />
[[1fle]] – pELA1+elafin<br /><br />
[[1b0e]], [[1b0f]] – pELA1+MDL<br /><br />
[[2v35]] – pELA1+JM54<br /><br />
[[2iot]] – pELA1+clavulanic acid<br /><br />
[[2de9]] – pELA1+tris<br /><br />
[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br /><br />
[[1gwa]] – pELA1+I3<br /><br />
[[1uo6]], [[1c1m]] – pELA1+Xe<br /><br />
[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br /><br />
[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br /><br />
[[2bda]] – pELA1+N-acetyl-NPI<br /><br />
[[1mcv]] – pELA1+squash inhibitor<br /><br />
[[1bma]] – pELA1+aminimide<br /><br />
[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br /><br />
[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br /><br />
[[1esa]], [[1esb]] – pELA1 intermediate<br /><br />
[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br /><br />
[[1inc]] – pELA1+benzoxazinone<br /><br />
[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br /><br />
[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br /><br />
[[3dbk]] – PaELA+phophoramidon – Pseudomonas aeruginosa<br /><br />
[[1u4g]] – PaELA+HPI<br /><br />
[[1ezm]] - PaELA<br /><br />
[[1elt]] – ELA - salmon<br /><br />
<br />
<br />
== ELA2 ==<br />
<br />
<br />
[[3q76]] – hELA2<br /><br />
[[3q77]] – hELA2+dihydropyrimidone inhibitor<br /><br />
[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br /><br />
[[2rg3]] – hELA2+sulfonic inhibitor<br /><br />
[[1h1b]], [[1ppg]], [[1hne]] – hELA2+inhibitor<br /><br />
[[1ppf]] – hELA2+ovomucoid<br /><br />
[[1b0f]] – hELA2+MDL101146<br /><br />
<br />
<br />
[[Category:Topic Page]]</div>
Guido Hansen
https://proteopedia.org/index.php?title=Elastase&diff=1243829
Elastase
2011-05-15T03:33:33Z
<p>Guido Hansen: </p>
<hr />
<div>[[Image:3ba0.png|left|200px|thumb|Crystal structure of full-length human Elastase (Metalloproteinase-12), [[3ba0]]]]<br />
{{STRUCTURE_3ba0| PDB=3ba0 | SIZE=300| SCENE=Elastase/Cv/2 |right|CAPTION=Human Elastase (Metalloproteinase-12), [[3ba0]] }}<br />
<br />
[[Elastase]] (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative elastase structure, ''i.e.'' the human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA ([[3ba0]]). Calcium ions are shown as green balls, zinc ions are grey balls and acetohydroxamic acid is shown as space filling object. <br />
<br />
{{TOC limit|limit=2}}<br />
<br />
<br />
== MMP12 ==<br />
<br />
<br />
[[3lka]] - hMMP12 catalytic domain+hydroxamic acid+paramethoxy-sulfonyl amide – human<br /><br />
[[3ba0]], [[1jk3]] – hMMP12<br /><br />
[[3ehx]], [[3ehy]], [[1utt]], [[1utz]], [[1ros]] - hMMP12 catalytic domain+inhibitor<br /><br />
[[2oxu]] - hMMP12 catalytic domain<br /><br />
[[2oxw]], [[2oxz]] - hMMP12 catalytic domain+peptide<br /><br />
[[2hu6]] - hMMP12 catalytic domain+bicyclic inhibitor<br /><br />
[[1rmz]] - hMMP12 catalytic domain+ inhibitor NNGH<br /><br />
[[1y93]] - hMMP12 catalytic domain+acetohydroxamic acid<br /><br />
[[1jiz]] – hMMP12+ hydroxamic acid<br /><br />
[[1os2]] - hMMP12 (mutant)+hydroxamic acid<br /><br />
[[1os9]] - hMMP12 (mutant)<br /><br />
[[3f15]], [[3f16]], [[3f17]], [[3f18]], [[3f19]], [[3f1a]] - hMMP12 catalytic domain+sulfonamide inhibitor<br /><br />
[[2w0d]] - hMMP12 catalytic domain (mutant)<br /><br />
[[2krj]], [[2k9c]] – hMMP12 fraction – NMR<br /><br />
[[2jxy]] - hMMP12 hemopexin-like domain – NMR<br /><br />
[[2k2g]] - hMMP12 catalytic domain+inhibitor – NMR<br /><br />
[[2poj]] - hMMP12 catalytic domain – NMR<br /><br />
[[2z2d]] - hMMP12 catalytic domain+butanoic acid – NMR<br /><br />
[[1ycm]], [[1z3j]] – hMMP12 (mutant)+hydroxamic acid derivative - NMR<br /><br />
[[3lk8]] - hMMP12 catalytic domain (mutant)+hydroxamic acid derivative<br /><br />
[[2wo8]], [[2wo9]], [[2woa]] – hMMP12 fraction+hydroxy carboxylic acid<br /><br />
[[3lik]], [[3lil]], [[3lir]], [[3ljg]] – hMMP12 catalytic domain (mutant)+chelating inhibitor<br />
<br />
== MMP16 ==<br />
<br />
<br />
[[1rm8]] – hMMP16+batimastat<br />
<br />
<br />
== ELA ==<br />
<br />
<br />
[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]] – pELA1 – pig<br /><br />
[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br /><br />
[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br /><br />
[[1fzz]] – pELA1+ONO-6818<br /><br />
[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br /><br />
[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br /><br />
[[1eai]] – pELA1+Ascaris inhibitor<br /><br />
[[2d26]] – pELA1+α-1-antitrypsin<br /><br />
[[1fle]] – pELA1+elafin<br /><br />
[[1b0e]], [[1b0f]] – pELA1+MDL<br /><br />
[[2v35]] – pELA1+JM54<br /><br />
[[2iot]] – pELA1+clavulanic acid<br /><br />
[[2de9]] – pELA1+tris<br /><br />
[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br /><br />
[[1gwa]] – pELA1+I3<br /><br />
[[1uo6]], [[1c1m]] – pELA1+Xe<br /><br />
[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br /><br />
[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br /><br />
[[2bda]] – pELA1+N-acetyl-NPI<br /><br />
[[1mcv]] – pELA1+squash inhibitor<br /><br />
[[1bma]] – pELA1+aminimide<br /><br />
[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br /><br />
[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br /><br />
[[1esa]], [[1esb]] – pELA1 intermediate<br /><br />
[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br /><br />
[[1inc]] – pELA1+benzoxazinone<br /><br />
[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br /><br />
[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br /><br />
[[3dbk]] – PaELA+phophoramidon – Pseudomonas aeruginosa<br /><br />
[[1u4g]] – PaELA+HPI<br /><br />
[[1ezm]] - PaELA<br /><br />
[[1elt]] – ELA - salmon<br /><br />
<br />
<br />
== ELA2 ==<br />
<br />
<br />
[[3q76]] – hELA2<br /><br />
[[3q75]] – hELA2+dihydropyrimidone inhibitor<br /><br />
[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br /><br />
[[2rg3]] – hELA2+sulfonic inhibitor<br /><br />
[[1h1b]], [[1ppg]], [[1hne]] – hELA2+inhibitor<br /><br />
[[1ppf]] – hELA2+ovomucoid<br /><br />
[[1b0f]] – hELA2+MDL101146<br /><br />
<br />
<br />
[[Category:Topic Page]]</div>
Guido Hansen