Proteopedia - User contributions [en]

Heather Kirby-sandbox

2014-12-10T15:37:34Z

Heather Kirby:

[[Media:Insulin.MOV]]==Insulin Molecule==

<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/10'>Cysteine on chain A</scene>

<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>
<scene name='61/611452/Proinsulin/1'>Proinsulin</scene>

Insulin is a hormone which is responsible for carbohydrate metabolism and storage. The body senses the concentration of glucose in the blood and responds by secreting insulin. Insulin is produced by beta cells in the pancreas.

The two chains shown, A and B, are the two pieces that make up insulin. These chains are joined by two disulfide bonds. The location of these bonds are represented by the labeled cysteine molecules on chains A and B. This is the active form of insulin. This form binds to muscle or fat cells to signal them to take up glucose, or sugar from the blood for storage.

Proinsulin is the precursor of insulin. It is produced by the pancreas and then converted into insulin. It can bind to the insulin receptor and exhibits 5% to 10% of the metabolic activity of insulin. A high concentration of proinsulin in the blood can be a warning sign of islet cell tumors.

Heather Kirby-sandbox

2014-12-10T15:35:13Z

Heather Kirby:

[[Media:Insulin.MOV]]==Insulin Molecule==

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/10'>Cysteine on chain A</scene>

<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>
<scene name='61/611452/Proinsulin/1'>Proinsulin</scene>

Insulin is a hormone which is responsible for carbohydrate metabolism and storage. The body senses the concentration of glucose in the blood and responds by secreting insulin. Insulin is produced by beta cells in the pancreas.

The two chains shown, A and B, are the two pieces that make up insulin. These chains are joined by two disulfide bonds. The location of these bonds are represented by the labeled cysteine molecules on chains A and B. This is the active form of insulin. This form binds to muscle or fat cells to signal them to take up glucose, or sugar from the blood for storage.

Proinsulin is the precursor of insulin. It is produced by the pancreas and then converted into insulin. It can bind to the insulin receptor and exhibits 5% to 10% of the metabolic activity of insulin. A high concentration of proinsulin in the blood can be a warning sign of islet cell tumors.

Heather Kirby-sandbox

2014-12-10T15:34:03Z

Heather Kirby:

[[Media:Insulin.MOV]]==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/10'>Cysteine on chain A</scene>

<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>
<scene name='61/611452/Proinsulin/1'>Proinsulin</scene>

Insulin is a hormone which is responsible for carbohydrate metabolism and storage. The body senses the concentration of glucose in the blood and responds by secreting insulin. Insulin is produced by beta cells in the pancreas.

The two chains shown, A and B, are the two pieces that make up insulin. These chains are joined by two disulfide bonds. The location of these bonds are represented by the labeled cysteine molecules on chains A and B. This is the active form of insulin. This form binds to muscle or fat cells to signal them to take up glucose, or sugar from the blood for storage.

Proinsulin is the precursor of insulin. It is produced by the pancreas and then converted into insulin. It can bind to the insulin receptor and exhibits 5% to 10% of the metabolic activity of insulin. A high concentration of proinsulin in the blood can be a warning sign of islet cell tumors.

[[Image:Example.jpg]]

Heather Kirby-sandbox

2014-12-10T14:28:45Z

Heather Kirby:

[[Media:Insulin.MOV]]==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/10'>Cysteine on chain A</scene>

<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>
<scene name='61/611452/Proinsulin/1'>Proinsulin</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-08T19:32:53Z

Heather Kirby:

File:Insulin.MOV

2014-12-08T19:31:29Z

Heather Kirby:

Heather Kirby-sandbox

2014-12-08T19:24:56Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/10'>Cysteine on chain A</scene>

<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-08T19:16:14Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/9'>Cysteine on chain A</scene>
<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-03T19:51:49Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/8'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-03T19:44:10Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/7'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-03T19:41:30Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/5'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-03T19:39:14Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/4'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-03T19:33:53Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Insulin,chains A(blue) and B(green)</scene>
<scene name='61/611452/All_atom/3'>Cysteine on chain B</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-01T19:36:39Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Start here</scene>
<scene name='61/611452/All_atom/3'>Cysteine on chain a</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-01T19:28:36Z

Heather Kirby:

==Insulin Molecule==
<StructureSection load='4ins' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

<scene name='61/611452/All_atom/1'>Start here</scene>

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

Heather Kirby-sandbox

2014-12-01T19:19:37Z

Heather Kirby: New page: ==Insulin Molecule== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Heather Kirby-sandbox'''. ...

==Insulin Molecule==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Heather Kirby-sandbox'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>