Proteopedia - User contributions [en]

User:Holly Rowe/Sandbox 1

2020-04-06T01:03:47Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial Calcium Uniporter 6DT0' scene=’’>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

Calcium is a very important signaling molecule in the body with many physiological functions including muscle contraction, neuron excitability, cell migration and growth. The mitochondria are important regulators of calcium in the body and the calcium uniporter (MCU) maintains calcium homeostasis within the mitochondria. Calcium moves in one direction from the intermembrane space through the inner mitochondrial membrane into the matrix. The matrix is more negative driven by the respiratory chain which draws calcium in and allows calcium to move down its gradient.
The MCU is a complex. Its MICU1 and MICU2 bind together and associate with EMRE which regulates MCU. The MICU1 and MICU2 act as gatekeepers. EMRE connects the MICU1 and MICU2 sensors to MCU therefore regulating calcium uptake for the protein

<scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene>
The selectivity pore is an integral part of the protein. This pore contains a group of glutamate with oxygen facing inward forming a carboxylate ring through which calcium enters. This negative carboxylate ring does a good job of pulling the positive calcium into the selectivity pore at the top of the protein. [[Image:carboxylate_ring.png|300 px|right|thumb|Figure 1 Carboxylate ring within the selectivity pore.]]
[https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy] Cryogenic electron microscopy (Cryo-EM) was instrumental in outlining the complete structure of this protein.

==Structure==
[[Image:Bubble_pic.png|300 px|right|thumb|Figure 2 Representation of the calcium fitting into the selectivity pore.]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>
<ref name=”Ransey”>PMID:28504306</ref>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

Sandbox Reserved 1609

2020-03-30T22:37:41Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial Calcium Uniporter 6DT0' scene=’’>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

Calcium is a very important signaling molecule in the body with many physiological functions including muscle contraction, neuron excitability, cell migration and growth. The mitochondria are important regulators of calcium in the body and the calcium uniporter (MCU) maintains calcium homeostasis within the mitochondria. Calcium moves in one direction from the intermembrane space through the inner mitochondrial membrane into the matrix. The matrix is more negative driven by the respiratory chain which draws calcium in and allows calcium to move down its gradient.
The MCU is a complex. Its MICU1 and MICU2 bind together and associate with EMRE which regulates MCU. The MICU1 and MICU2 act as gatekeepers. EMRE connects the MICU1 and MICU2 sensors to MCU therefore regulating calcium uptake for the protein

<scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene>
The selectivity pore is an integral part of the protein. This pore contains a group of glutamate with oxygen facing inward forming a carboxylate ring through which calcium enters. This negative carboxylate ring does a good job of pulling the positive calcium into the selectivity pore at the top of the protein. [[Image:carboxylate_ring.png|300 px|right|thumb|Figure 1 Carboxylate ring within the selectivity pore.]]

==Structure==
[[Image:Bubble_pic.png|300 px|right|thumb|Figure 2 Representation of the calcium fitting into the selectivity pore.]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>
<ref name=”Ransey”>PMID:28504306</ref>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

User:Holly Rowe/Sandbox 1

2020-03-24T12:47:30Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial Calcium Uniporter 6DT0' scene=’’>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

Calcium is a very important signaling molecule in the body with many physiological functions including muscle contraction, neuron excitability, cell migration and growth. The mitochondria are important regulators of calcium in the body and the calcium uniporter (MCU) maintains calcium homeostasis within the mitochondria. Calcium moves in one direction from the intermembrane space through the inner mitochondrial membrane into the matrix. The matrix is more negative driven by the respiratory chain which draws calcium in and allows calcium to move down its gradient.
The MCU is a complex. Its MICU1 and MICU2 bind together and associate with EMRE which regulates MCU. The MICU1 and MICU2 act as gatekeepers. EMRE connects the MICU1 and MICU2 sensors to MCU therefore regulating calcium uptake for the protein

<scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene>
The selectivity pore is an integral part of the protein. This pore contains a group of glutamate with oxygen facing inward forming a carboxylate ring through which calcium enters. This negative carboxylate ring does a good job of pulling the positive calcium into the selectivity pore at the top of the protein. [[Image:carboxylate_ring.png|300 px|right|thumb|Figure 1 Carboxylate ring within the selectivity pore.]]

==Structure==
[[Image:Bubble_pic.png|300 px|right|thumb|Figure 2 Representation of the calcium fitting into the selectivity pore.]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>
<ref name=”Ransey”>PMID:28504306</ref>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

File:Carboxylate ring.png

2020-03-24T12:38:59Z

Holly Rowe: Carboxylate ring within the selectivity pore.

Carboxylate ring within the selectivity pore.

User:Holly Rowe/Sandbox 1

2020-03-24T12:33:23Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial Calcium Uniporter 6DT0' scene=’’>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

Calcium is a very important signaling molecule in the body with many physiological functions including muscle contraction, neuron excitability, cell migration and growth. The mitochondria are important regulators of calcium in the body and the calcium uniporter (MCU) maintains calcium homeostasis within the mitochondria. Calcium moves in one direction from the intermembrane space through the inner mitochondrial membrane into the matrix. The matrix is more negative driven by the respiratory chain which draws calcium in and allows calcium to move down its gradient.
The MCU is a complex. Its MICU1 and MICU2 bind together and associate with EMRE which regulates MCU. The MICU1 and MICU2 act as gatekeepers. EMRE connects the MICU1 and MICU2 sensors to MCU therefore regulating calcium uptake for the protein

<scene name='83/837219/Selectivity_pore/1'>Selectivity Pore</scene>
The selectivity pore is an integral part of the protein. This pore contains a group of glutamate with oxygen facing inward forming a carboxylate ring through which calcium enters. This negative carboxylate ring does a good job of pulling the positive calcium into the selectivity pore at the top of the protein.

==Structure==
[[Image:Bubble_pic.png|400 px|right|thumb|Figure 1 The coolest image of this protein!]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>
<ref name=”Ransey”>PMID:28504306</ref>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

User:Holly Rowe/Sandbox 1

2020-03-02T20:34:52Z

Holly Rowe:

User:Holly Rowe/Sandbox 1

2020-03-02T20:31:40Z

Holly Rowe:

User:Holly Rowe/Sandbox 1

2020-03-02T20:19:04Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='6DT0' size='350' frame='true' side='right' caption='Mitochondrial Calcium Uniporter 6DT0' scene=’<scene name='83/837219/Selectivity_pore/1'>TextToBeDisplayed</scene>’>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

==Structure==
[[Image:Bubble_pic.png|400 px|right|thumb|Figure 1 The coolest image of this protein!]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

User:Holly Rowe/Sandbox 1

2020-03-02T20:05:13Z

Holly Rowe:

User:Holly Rowe/Sandbox 1

2020-03-02T20:02:18Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
[https://www.rcsb.org/structure/6dt0 Calcium Uniporter PDB File]

==Structure==
[[Image:Bubble_pic.png|400 px|right|thumb|Figure 1 The coolest image of this protein!]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

User:Holly Rowe/Sandbox 1

2020-03-02T19:57:37Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==

==Structure==
[[Image:Bubble_pic.png|400 px|right|thumb|Figure 1 The coolest image of this protein!]]

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

File:Bubble pic.png

2020-03-02T19:45:40Z

Holly Rowe:

User:Holly Rowe/Sandbox 1

2020-03-02T19:37:21Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==

==Structure==

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

==Student Contributors==
*Holly Rowe
*Lizzy Ratz
*Maddi Summers

User:Holly Rowe/Sandbox 1

2020-03-02T19:35:00Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==

==Structure==

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

User:Holly Rowe/Sandbox 1

2020-03-02T19:33:40Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==
===Structure===

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

User:Holly Rowe/Sandbox 1

2020-03-02T19:31:03Z

Holly Rowe:

=''Mitochondrial Calcium Uniporter''=
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
==Introduction==

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

User:Holly Rowe/Sandbox 1

2020-03-02T19:27:02Z

Holly Rowe:

==Mitochondrial Calcium Uniporter==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

User:Holly Rowe/Sandbox 1

2020-03-02T19:22:14Z

Holly Rowe: New page: ==Your Heading Here (maybe something like 'Structure')== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for you...

==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page '''Holly Rowe/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

User:Holly Rowe

2020-03-02T19:19:51Z

Holly Rowe:

*[[User:Holly Rowe/Sandbox 1]]
* Full Real Name: Holly Rowe

* Position: Student

* Institution (NO ABBREVIATIONS): Butler University

* City, State/Province, Country: Indianapolis, IN, USA

* Field of Expertise or Study: Biochemistry

User:Holly Rowe

2020-03-02T19:19:34Z

Holly Rowe:

*[[User:Holly Rowe/Sandbox 1]]* Full Real Name: Holly Rowe

* Position: Student

* Institution (NO ABBREVIATIONS): Butler University

* City, State/Province, Country: Indianapolis, IN, USA

* Field of Expertise or Study: Biochemistry