Proteopedia - User contributions [en]

Institute of Clinical Biochemistry

2008-06-18T11:50:59Z

Ida Rosnes:

=About IKB=

Institute of Clinical Biochemistry (IKB) is situated at the Rikshospitalet University Hospital, and is part of the University of Oslo (Norway)

=Research at IKB=

[[Image:1web.jpg|400px|thumb|Photo: Killian Munch]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

[[Image:Oxygraph_study.JPG|300px|thumb|Photo: Killian Munch]]

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide<@>rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid<@>medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-10T12:39:20Z

Ida Rosnes:

=About IKB=

Institute of Clinical Biochemistry (IKB) is situated at the Rikshospitalet University Hospital, and is part of the University of Oslo (Norway)

=Research at IKB=

[[Image:1web.jpg|400px|thumb|Photo: Killian Munch]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

[[Image:Oxygraph_study.JPG|300px|thumb|Photo: Killian Munch]]

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-10T11:03:28Z

Ida Rosnes:

=Research at IKB=

[[Image:1web.jpg|400px|thumb|Photo: Killian Munch]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

[[Image:Oxygraph_study.JPG|300px|thumb|Photo: Killian Munch]]

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-10T10:59:20Z

Ida Rosnes:

File:Oxygraph study.JPG

2008-06-10T10:58:07Z

Ida Rosnes:

== Licensing ==
{{subst:Permission from license selector}}

Institute of Clinical Biochemistry

2008-06-10T07:28:13Z

Ida Rosnes:

=Research at IKB=

[[Image:1web.jpg|400px|thumb|Photo: Killian Munch]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-10T07:25:55Z

Ida Rosnes:

=Research at IKB=

[[1web.jpg|400px|thumb|Photo: Killian Munch]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

User talk:Ida Rosnes

2008-06-10T07:22:22Z

Ida Rosnes:

'''Welcome to ''Proteopedia''!''' We hope you will contribute much and well.
You will probably want to read the [[Help:Contents|help pages]]. Again, welcome and have fun! [[User:Eran Hodis|Eran Hodis]] 17:33, 6 June 2008 (IDT)

== IKB Page ==

Hi Ida,

Your IKB page looks good. Try adding some pictures as well as 3D sections explaining about some proteins solved or studied at IKB. Alternatively you could expand the pages of those proteins and then link to them from the IKB page. This will certainly make the page much more interactive!

It was great meeting you in Erice. Keep in touch and congratulations on your prize! I was very happy for you when they announced your name.

Best,
[[User:Eran Hodis|Eran Hodis]] 23:57, 9 June 2008 (IDT)

Hello ;o)

Nice to hear from you so soon! You have full control over Proteopedia...scary ;0) Hehe. The IKB page is quite boring right now, and I'm planning to add some photos soon. Right now I'm a little bit busy solving some structures, but hopefully I will try to teach my colleges how to use it in some weeks. Proteopedia is really cool!!! I'm going to write about the meeting in a Norwegian Biochemistry paper, and wan't to tell about Proteopedia as well. If you got some great sentences to describe Proteopedia, just tell me. But I'm sure I will find all what I need here.

I really miss Erice. I did'nt have time to say goodbye...Hopefully I will see you again in 2 years or so. And thank you, I really happy about the price. Wow!!

We'll be in touch

Ida

Hopefully :). Congratulations about the Prize, again.

Some Proteopedia related stuff: If you want to write me a note, you can visit my user page and click on "discussion". Anything you edit there, I will get a notice in my email saying that my page has been changed. Of course I don't have full control over Proteopedia, it's a community resource :), but it would be just great if you wrote about it in your Norwegian Biochemistry paper -- please keep me updated about that. Oh yea, and to sign your name, you just type <nowiki>~~~~</nowiki>. It automatically adds your name, and the time. For example: Ciao! [[User:Eran Hodis|Eran Hodis]] 00:44, 10 June 2008 (IDT)

== Uploading Images ==

Hi Ida,

It is kind of funny that I'm on the website exactly when you are, but I noticed that you uploaded an image. Try to give a more descriptive name to your images (under the "destination name" input area). Enjoy!
Eran

Hi

Haha...This is spooky!! Will do

Ida

Institute of Clinical Biochemistry

2008-06-10T07:14:16Z

Ida Rosnes:

=Research at IKB=

[[1web.jpg]]

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

File:1web.jpg

2008-06-10T07:07:18Z

Ida Rosnes:

== Licensing ==
{{subst:Permission from license selector}}

User talk:Ida Rosnes

2008-06-09T21:29:44Z

Ida Rosnes:

Institute of Clinical Biochemistry

2008-06-08T20:38:38Z

Ida Rosnes:

=Research at IKB=

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visit the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-08T20:05:16Z

Ida Rosnes:

=Research at IKB=

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visitt the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-08T20:04:06Z

Ida Rosnes:

=Research at IKB=

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: the molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visitt the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an External Master Degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-07T09:39:37Z

Ida Rosnes:

=Research at IKB=

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: the molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visitt the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

=Studies=

Academic staff at the institute is involved in PBL-based teaching.

Lars Eide 23071062; (lars.eide@rr-research.no)
Lars Mørkrid 23071075; (lars.morkrid@medisin.uio.no)

==External Master Degree==

We have previously supervised students who want to arrange an external Master degree. In addition, we can accommodate students from "forskerlinjen" in medicine.

Institute of Clinical Biochemistry

2008-06-07T09:31:57Z

Ida Rosnes:

=Research at IKB=

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

===Mitochondria: DNA and function===

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

===DNA-repair: the molecular- and structural biology of DNA base lesions===

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

===Core facility for structural biology===

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visitt the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

Institute of Clinical Biochemistry

2008-06-07T09:30:18Z

Ida Rosnes:

===Research at IKB===

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).

==Research areas==

=Mitochondria: DNA and function=

The mitogroup focuses on function of mitochondria in relation to oxidative stress and mtDNA damage. Oxidative stress damages mtDNA but also suppresses respiratory function of mitochondria. Particular interest is the interplay between respiration function and mtDNA damage accumulation/repair. Molecular methods are used to characterize damage and repair of mtDNA, assembly of mitochondrial complexes in the mitochondrial inner membrane in addition to functional assessment by high-resolution respirometry and in vivo confocal imaging.

=DNA-repair: the molecular- and structural biology of DNA base lesions=

The DNA repair group focuses on how DNA base lesions are detected and processed by the various DNA repair proteins within the cell. We aim at mapping the molecular principles of recognition of specific base lesions that occur in DNA as a consequence of different processes like oxidation of DNA, damages by electromagnetic radiation, contact with reactive chemicals or different carcinogenic compounds. We use both biological and biochemical methods to study the function of single DNA repair proteins as well as the interplay between different proteins. Further, we also use methods within molecular biology like site-spesific mutagenesis and cloning in order to map the function and lesion specificity of the DNA repair proteins. We also take the advantage of structural biology (protein structure determination) and the optical laser tweezers to study the molecular interactions and dynamics of the different repair proteins.

=Core facility for structural biology=

The DNA repair group also operate the Core facility for structural biology, which serves research groups associated with Rikshospitalet-Radiumhospitalet Medical Center as well as groups belonging to the University of Oslo. We can offer counseling and practical training within protein expression and purification. We also offer experimental structure determination of protein structures and different bioinformatics analysis on a collaborative basis. For more information, please visitt the Core Facility home page:

[http://core.rr-research.no/index.php?section=4]

Institute of Clinical Biochemistry

2008-06-07T09:25:17Z

Ida Rosnes: New page: ==Research at Institute of Clinical Biochemistry (IKB)== Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to underst...

==Research at Institute of Clinical Biochemistry (IKB)==

Research at IKB aims to unravel the dynamic interplay between cellular processes on a molecular level, that can be used to understand and treat disease. Of particular interest are processes related to DNA integrity and mitochondrial biology.
IKB has established methodology within structural and mitochondrial biology like advanced protein purification, X-ray crystallography, separation and analysis of large protein complexes, high resolution respirometry, confocal microscopy for in vivo imaging in addition to laser-tweezers microscopy to study molecular interactions.
The research groups at IKB have collaborative projects with external groups at Rikshospitalet-Radiumhospitalet Medical Centre, with various institutes at the University of Oslo as well as with research groups abroad. The institute hosts the core facility for structural biology (protein crystallography) at Rikshospitalet-Radiumhospitalet Medical Centre. Two of the research groups are involved in the Centre for Molecular Biology and Neuroscience (CMBN; one of the Centers of Excellence in Science in Norway).