Proteopedia - User contributions [en]

DNA Polymerase in Thermococcus gorgonarius

2018-10-28T23:36:53Z

Kayla Briley: Sandbox Reserved 1108 moved to DNA Polymerase in Thermococcus gorgonarius: name chang

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase in ''Thermococcus gorgonarius''==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
'''DNA polymerase''' is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' (''Tgo'') plays an important role in the development of life for this organism. In ''Tgo'', DNA polymerase take on the same role of synthesizing new DNA as it does in every organism. Although ''Tgo''’s DNA polymerase plays the same role, it does deffer from the human DNA polymerase. The DNA polymerase in ''Tgo'' is more thermally stable. Its stability can withstand temperature up to around 95 degrees Celsius (203 degrees Fahrenheit). <ref name="Thermococcus">PMID:10097083</ref> Human DNA polymerase optimum temperature is around 75 degrees Celsius (167 degrees Fahrenheit). <ref>PMID:3200828</ref>

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. ''Tgo'' is a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in ''Tgo'' are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the preexisting base. The thumb (red) helps the positioning of the DNA and with translocation. <ref name="Thermococcus">PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius (131-203 degrees Fahrenheit). In order to replicate properly, the DNA polymerase must be stable and be able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref name="Thermococcus">PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located within the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius (239 degrees Fahrenheit). With these disulfide bond and structural folding this molecule is more thermostable. <ref name="Thermococcus">PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T06:03:26Z

Kayla Briley:

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:55:43Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase in ''Thermococcus gorgonarius''==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
'''DNA polymerase''' is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' (''Tgo'') plays an important role in the development of life for this organism. In ''Tgo'', DNA polymerase take on the same role of synthesizing new DNA as it does in every organism. Although ''Tgo''’s DNA polymerase plays the same role, it does deffer from the human DNA polymerase. The DNA polymerase in ''Tgo'' is more thermally stable. Its stability can withstand temperature up to around 95 degrees Celsius (203 degrees Fahrenheit). <ref name="Thermococcus">PMID:10097083</ref> Human DNA polymerase optimum temperature is around 75 degrees Celsius (167 degrees Fahrenheit). <ref>PMID:3200828</ref>

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref name="Thermococcus">PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref name="Thermococcus">PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable. <ref name="Thermococcus">PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:48:03Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase in ''Thermococcus gorgonarius''==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' (''Tgo'') plays an important role in the development of life. In ''Tgo'', DNA polymerase take on the same role of synthesizing new DNA as it does in every organism. Although ''Tgo''’s DNA polymerase plays the same role, it does have a few difference from the human DNA polymerase. The DNA polymerase in ''Tgo'' is more thermally stable. Its stability can withstand temperature up to around 95 degrees Celsius (203 degrees Fahrenheit). <ref name="Thermococcus">PMID:10097083</ref> Human DNA polymerase optimum temperature is around 75 degrees Celsius (167 degrees Fahrenheit). <ref>PMID:3200828</ref>

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref name="Thermococcus">PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref name="Thermococcus">PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable. <ref name="Thermococcus">PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:18:39Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase in ''Thermococcus gorgonarius''==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' plays an important role in the development of life.

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref name="Thermococcus">PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref name="Thermococcus">PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable. <ref name="Thermococcus">PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:13:49Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' plays an important role in the development of life.

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref name="Thermococcus">PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref name="Thermococcus">PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable. <ref name="Thermococcus">PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:12:09Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' plays an important role in the development of life.

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMID:10097083</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding. <ref>PMID:10097083</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable. <ref>PMID:10097083</ref>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T05:05:06Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. DNA polymerases are the enzymes which catalyze the attachment of nucleotides one by one to synthesize a new DNA strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading of new DNA from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states there is an equal amount of purines to pyrimidines. From Chargaff’s rule it is known that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase makes roughly only one mistake per every billion base. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases, after replication, is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' plays an important role in the development of life.

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T04:50:32Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>
'''DNA polymerase''' is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of DNA polymerase in ''Thermococcus gorgonarius'' plays an important role in the development of life.

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T04:47:02Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>

'''DNA polymerase''' has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of ''Thermococcus gorgonarius''

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T04:46:22Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>

DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of ''Thermococcus gorgonarius''

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T04:38:10Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>

== Overview ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Function ==
The function of ''Thermococcus gorgonarius''

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T04:01:24Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase from ''Thermococcus gorgonarius'' ' scene=''>

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Structural Highlights ==
DNA polymerase from ''Thermococcus gorgonarius'' (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T03:52:06Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref name="PDBDNAPOL">DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Structural Highlights ==
DNA polymerase from Thermococcus gorgonarius (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T03:48:54Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref> DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Structural Highlights ==
DNA polymerase from Thermococcus gorgonarius (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T03:37:38Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>

== Structural Highlights ==
DNA polymerase from Thermococcus gorgonarius (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>
== Stabilization ==
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T03:34:44Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/

== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (''Tgo'') is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>

==Stabilization==http://www.proteopedia.org/wiki/skins/common/images/button_italic.png
''Thermococcus gorgonarius'' (''Tgo'') is a very thermophilic molecule with a growth range between 55-95 degrees Celsius. In order to replicate properly, the DNA polymerase must be stable and able to tolerate binding to the substrate DNA. ''Tgo'' polymerase contains 41% helix, 22% beta-stands, and 19% turns and also has an increase in hydrogen bonding.

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene>, which are formed at two different cysteine pairs in ''Thermococcus gorgonarius''. Each sulfur atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (residue 428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond composed of cysteine (506) and cysteine (509) creates more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point is about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T03:04:57Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/

== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene> are formed at two different cysteine pairs in Thermococcus gorgonarius. Each sulfide atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond created by cysteine (506) and cysteine (509) create more stabilization for the helix in the palm domain at a helical turn. Sulfurs can withstand high temperature because their melting point about 115 degrees Celsius. With these disulfide bond and structural folding this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T02:45:03Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/

== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>

There are two separate <scene name='71/713469/Disulfidebond/2'>disulfide bonds</scene> are formed at two different cysteine pairs in Thermococcus gorgonarius. Each sulfide atom is shown in yellow. Both of the cysteines are located on the palm domain. One disulfide bonds between cysteine (428) and cysteine (442) stabilize the molecule at one of the folds between a helix in the palm domain and a helix located in the finger domain. While the other disulfide bond created by cysteine (506) and cysteine (509) create more stabilization for the helix in the palm domain at a helical turn. With these disulfide bond this molecule is more thermostable.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T02:25:26Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/

== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>

<scene name='71/713469/Disulfidebond/2'>TextToBeDisplayed</scene>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T02:22:55Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/

== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region (blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and with translocation. <ref>PMCID:PMC22340</ref>

<scene name='71/713469/Disulfidebond/1'>disulfide bonds</scene>

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T02:03:19Z

Kayla Briley:

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T01:49:50Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI:10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and also helps with the translocation. <ref>PMCID:PMC22340</ref>

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T01:34:17Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule. The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and also helps with the translocation. <ref>PMCID:PMC22340</ref>

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T01:32:38Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule <ref>PMCID:PMC22340</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the newly incoming nucleotides and the template bases that are paired together with the nucleotides. The thumb (red) helps position the DNA and also helps with the translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T00:11:40Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule <ref>PMCID:PMC22340</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T00:09:58Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule <ref>PMID:1tgo</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-04T00:07:20Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius (Tgo) is composed of 2,319 nucleotides. Tgo a single polypeptide chain made up of 773 amino acids which are folded into five domains. The five domains in Tgo are the N-terminal, 3’ to 5’ exonuclease, palm, fingers, and the thumb. These five domain are arranged to form a ring shaped molecule <ref>PMCID:PMC22340</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T23:31:41Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius is composed of 2,319 nucleotides. The polypeptide is compiled of 773 residues, once it is completely translated.DNA polymerase contain 30 α-helices (39%) and 29 β-sheets(22%). <ref>DOI: 10.2210/pdb1tgo/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T23:09:57Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>PMID:10036207</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase from Thermococcus gorgonarius is composed of 2,496 nucleotides. The polypeptide is compiled of 832 amino acid, once it is completely translated. <ref>PMID:9514116</ref> DNA polymerase contain nineteen α-helices and twenty-nine β-sheets. <ref>PMID:10097083</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T22:28:57Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. <ref>DOI10.1007/BF02173653/pdb</ref> Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. <ref>DOI10.2210/pdb7icg/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region(blue) catalyzes the phosphoric transfer. The finger region (green) interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T21:31:10Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. <ref>DOI10.2210/pdb7icg/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a <scene name='71/713469/Palmthumbfinger/1'>“palm”, “fingers”, and “thumb” regions</scene>. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T21:16:43Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1TGO' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. <ref>DOI10.2210/pdb7icg/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a “palm”, “fingers”, and “thumb” regions. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T03:53:54Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. <ref>DOI10.2210/rcsb_pdb/mom_2000_3</ref>
== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. <ref>DOI10.2210/pdb7icg/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a “palm”, “fingers”, and “thumb” regions. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-03T03:43:29Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. <ref>DOI10.2210/pdb7icg/pdb</ref>
The structure of DNA polymerase can be described by using the “right hand model” which has a “palm”, “fingers”, and “thumb” regions. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-02T02:18:01Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
DNA polymerase is composed of 1,005 nucleotides. The polypeptide is compiled of 335 residues, once it is translated. DNA polymerase contain nineteen α-helices and eight β-sheets. (http://www.rcsb.org/pdb/explore.do?structureId=7ICG)
The structure of DNA polymerase can be described by using the “right hand model” which has a “palm”, “fingers”, and “thumb” regions. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-02T02:00:49Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
The structure of DNA polymerase can be described by using the “right hand model” which has a “palm”, “fingers”, and “thumb” regions. The palm region catalyzes the phosphoric transfer. The finger region interacts with the incoming nucleotides and the template base they are paired with and the thumb helps in positioning the DNA and in translocation.(http://www.worthington-biochem.com/DNAECI/default.html)

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-02T01:30:47Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==
Right Hand Model
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-02T01:16:20Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='DNA Polymerase-Beta' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==
DNA polymerase has an important role in the development of life. DNA polymerase is an enzyme, which synthesizes new stands of DNA from preexisting DNA. It does this by adding one nucleotide at a time to the 3’ end of a growing strand. The new DNA strands are always synthesized from 5’ to the 3’ direction. (GENETICS BOOK) The original DNA stands are used as templates for the synthesis of new strands of DNA. DNA polymerases are the enzymes that catalyze the attachment of nucleotides to synthesize a new DNA strand. DNA polymerase I is composed of a single polypeptide that removes the RNA primers and replaces them with DNA. DNA polymerase III is responsible for the majority of the DNA replication and the proofreading from 3’ to 5’. DNA follows Chargaff’s rule, which states that cytosine binds to guanine and adenine binds to thymine. (http://www.slideshare.net/JordiMartin1/chap11-studyppt) Each time a cell divides, DNA polymerase duplicates all of the cell’s DNA, and the cell passes one copy of DNA to each daughter cell. DNA polymerase roughly makes only one mistake every billion bases. Although Chargaff’s rule help makes the replication on DNA polymerase easier, an extra step of proofreading and cutting out the mismatched bases after replication is the reason why DNA polymerase is the most accurate enzyme. (http://www.rcsb.org/pdb/101/motm.do?momID=3)

== Disease ==
http://tools.niehs.nih.gov/polg/
== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-12-01T22:41:39Z

Kayla Briley:

DNA Polymerase in Thermococcus gorgonarius

2015-12-01T22:35:28Z

Kayla Briley:

DNA Polymerase in Thermococcus gorgonarius

2015-11-18T01:01:01Z

Kayla Briley:

DNA Polymerase in Thermococcus gorgonarius

2015-11-18T00:59:13Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='7icg' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-11-18T00:11:19Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==DNA Polymerase==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>

DNA Polymerase in Thermococcus gorgonarius

2015-11-04T17:44:11Z

Kayla Briley:

{{Sandbox_Reserved_JMeans}}
==Your Heading Here (maybe something like 'Structure')==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name="structure">PMID:21638687</ref> to the rescue.<ref name="structure" />

== Function ==

== Disease ==

== Relevance ==

== Structural highlights ==

This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>
== References ==
<references/>