Proteopedia - User contributions [en]

Tetherin

2009-12-15T03:24:31Z

Kim Smith:

==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==
Tetherin has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles.
The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine.

While tetherin may be an effective inhibitor of some viruses, other viruses have been shown to produce viral proteins that downregulates the production and expression of some cellular proteins, including tetherin. Some strains of HIV-1 as well as Ebola viral particles produce viral proteins shown to downregulation tetherin expression on the surface of the cell membrane.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

== References ==
Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. ''Journal of Virology''. 83:2382-2385.

Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. ''Nature''.'' 451: 425-430.

Tetherin

2009-12-15T03:19:07Z

Kim Smith:

==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==
Tetherin has been shown to prevent the release of HIV-1 virions and may be an effective inhibitor of other enveloped viruses as well such as Lassa and Marburg viruses. Tetherin inhibits the release of virions by binding to viral particles budding from the cell membrane, preventing the release of these infectious particles.
The tetherin protein is always found on the surface of B lymphocytes, dendritic cells, and activated T lymphocytes. In brain, kidney, liver, skeletal muscle, pancreas and heart cells, the tetherin gene can be stimulated to be expressed by the production of alpha Interferon, a cytokine.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

== References ==
Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. ''Journal of Virology''. 83:2382-2385.

Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. ''Nature''.'' 451: 425-430.

Tetherin

2009-08-28T21:43:56Z

Kim Smith:

==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells==

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_3cin | PDB=3cin | SCENE= }}

== References ==
Sakuma, Noda, Urata, Kawaoka, & Yasuda (2009). Inhibition of Lassa and Marburg Virus Production by Tetherin. ''Journal of Virology''. 83:2382-2385.

Neil, Zang, & Beiniasz (2008). Tetherin inhibits retroviral release and is antagonized by HIV-1 Vpu. ''Nature''.'' 451: 425-430.

User:Kim Smith

2009-08-28T21:30:08Z

Kim Smith:

I currently teach AP Biology and Microbiology at Homewood-Flossmoor High School. I hold an MS in Biology from Purdue University, Calumet, an MA in Education from Saint Xavier University, a BS in Biology from Saint Xavier University in Chicago.
I have always been interested in molecular biology and continue to take courses at Chicago universities. I was introduced to Proteopedia while taking a course at MSOE in Milwaukee and started a Proteopedia site about C-myc and have been incorporating what I have learned about C-myc and Proteopedia into my classroom. At the present time, one of my students, Hillary Sigale is continuing to research C-myc and will be contributing to the C-myc website in the near future.

Tetherin

2009-08-27T01:11:21Z

Kim Smith: New page: ==Tetherin is a membrane-associated protein that may prevent the release of enveloped viruses from their host cells== Replace the PDB id (use lowercase!) after the STRUCTURE_ and after P...

C-Myc

2009-07-16T17:54:17Z

Kim Smith:

<applet load='2A93-custom.pdb' size='400' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]' scene='C-Myc/Custom/2'/>

== Overview ==

----

<scene name='C-Myc/Custom/2'>TextToBeDisplayed</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:52:16Z

Kim Smith:

<applet load='2A93-custom.pdb' size='400' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]' scene name='C-Myc/Custom/2'/>

== Overview ==

----

<scene name='C-Myc/Custom/2'>TextToBeDisplayed</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:46:07Z

Kim Smith:

<applet load='2A93-custom.pdb' size='400' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

File:2A93-custom.pdb

2009-07-16T17:44:21Z

Kim Smith: Custom PDB file 2A93 (models 2-40 deleted)

Custom PDB file 2A93 (models 2-40 deleted)

C-Myc

2009-07-16T17:37:48Z

Kim Smith:

<applet load='2a93' size='400' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

<scene name='C-Myc/Custom/1'>Click this</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:36:12Z

Kim Smith:

<applet load='2a93' size='400' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]' scene name='C-Myc/Custom/1'/>

== Overview ==

----

<scene name='C-Myc/Custom/1'>Click this</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:31:46Z

Kim Smith:

C-Myc

2009-07-16T17:27:02Z

Kim Smith:

<applet load='2a93' size='400' frame='true' align='right' scene name='C-Myc/Custom/1' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

<scene name='C-Myc/Custom/1'>Click this</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:24:16Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

<scene name='C-Myc/Custom/1'>Click this</scene>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T17:00:35Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

Kaji, Norrby, Paca, Mileikovsky, Mohseni, & Woltjen (2009) Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-776.

C-Myc

2009-07-16T16:57:22Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

== Overview ==

----

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12.

C-Myc

2009-07-16T16:52:55Z

Kim Smith:

<nowiki>Insert non-formatted text here</nowiki><applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. [http://www.ncbi.nlm.nih.gov/pubmed/9858526 Molecular and Cellular Biology], 19: 1-11.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179.

C-Myc

2009-07-16T16:50:19Z

Kim Smith:

C-Myc

2009-07-16T16:47:58Z

Kim Smith:

<nowiki>Insert non-formatted text here</nowiki><applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. Molecular and Cellular Biology, 19: 1-12.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. [http://www.ncbi.nlm.nih.gov/pubmed/12553908 Cell], 112:193-205.

C-Myc

2009-07-16T16:41:14Z

Kim Smith:

<nowiki>Insert non-formatted text here</nowiki><applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

== References ==

----
Dang, C.V.(1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. Molecular and Cellular Biology, volume 19, number 1.

Nair & Burley (2003) X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA: Molecular Bases of Regulation by Proto-Oncogenic Transcription Factors. Cell, 112:193-205.

C-Myc

2009-07-16T15:32:24Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-16T15:29:28Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/>

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-16T15:26:31Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein'] />

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T21:33:54Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a DNA binding protein' />

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T20:18:17Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T20:11:36Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T20:06:47Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T20:05:31Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc, which is involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T19:59:40Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc --[[User:Kim Smith|Kim Smith]] 22:59, 15 July 2009 (IDT)oncogene[[Media:http://en.wikipedia.org/wiki/Oncogene ]] encodes a transcription factor, c-Myc, which is involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T19:55:00Z

Kim Smith: c-Myc forms a hetero-dimer with Max

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc [[onco-protein]] is a transcription factor involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

C-Myc

2009-07-15T19:51:58Z

Kim Smith:

<applet load='2a93' size='300' frame='true' align='right' caption='Insert caption here' />19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2a93 | SCENE= }}

The c-Myc onco-protein is a transcription factor involved in the regulation of the cell cycle. C-Myc belongs to the Myc family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a b-HLH-LZ (basic helix-loop-helix-leucine zipper) protein that must form a heterodimer with another b-HLH-LZ protein, Max, in order to bind DNA and activate transcription.
Mutations in myc proteins or overexpression of their encoding genes has been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.

User:Kim Smith

2009-07-15T19:18:03Z

Kim Smith:

I currently teach AP Biology and Microbiology at Homewood-Flossmoor High School. I currently hold an MS in Biology from Purdue University, Calumet, an MA in Education from Saint Xavier University, a BS in Biology from Saint Xavier University in Chicago and I am continuing my education in molecular and microbiology at various Chicagoland Universities.

C-Myc

2009-07-15T18:54:18Z

Kim Smith:

C-Myc

2009-07-15T16:45:08Z

Kim Smith: c-Myc is a common transcription factor

19:45, 15 July 2009 (IDT)[[User:Kim Smith|Kim Smith]]==This is a placeholder==
This is a placeholder text to help you get started in
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.

Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.

{{STRUCTURE_c-Myc PDB=2A93A | SCENE= }}