https://proteopedia.org/api.php?action=feedcontributions&feedformat=atom&user=Logan+Brushart 2026-09-24T21:46:53Z User contributions MediaWiki 1.43.8 https://proteopedia.org/index.php?title=Glucose-dependent_Insulinotropic_Polypeptide_Receptor&diff=1329859 2011-12-09T19:24:45Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- <br /> Please use the &quot;3D&quot; button above this box to insert a Jmol applet (molecule) on this page.<br /> Or use the four-green-boxes-button to insert scrollable text adjacent<br /> to a Jmol applet. Check out the other buttons as well! <br /> --&gt;<br /> <br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function===<br /> The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes action of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin&lt;ref&gt;PMID:11334402&lt;/ref&gt;. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;.<br /> <br /> [[Image:F3.large.jpg|thumb|400px|left|GIP-induced Pathway.&lt;ref&gt;PMID:12475913&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Glucose-dependent_Insulinotropic_Polypeptide_Receptor&diff=1329858 2011-12-09T19:24:21Z

<p>Logan Brushart: New page: &lt;!-- Please use the &quot;3D&quot; button above this box to insert a Jmol applet (molecule) on this page. Or use the four-green-boxes-button to insert scrollable text adjacent to a Jmol applet. Che...</p> <hr /> <div>&lt;!-- <br /> Please use the &quot;3D&quot; button above this box to insert a Jmol applet (molecule) on this page.<br /> Or use the four-green-boxes-button to insert scrollable text adjacent<br /> to a Jmol applet. Check out the other buttons as well! <br /> --&gt;<br /> <br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function===<br /> The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes action of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin&lt;ref&gt;PMID:11334402&lt;/ref&gt;. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;.<br /> <br /> [[Image:F3.large.jpg|thumb|400px|left|GIP-induced Pathway.&lt;ref&gt;PMID:12475913&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1329851 2011-12-09T19:14:26Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function===<br /> The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes action of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin&lt;ref&gt;PMID:11334402&lt;/ref&gt;. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;.<br /> <br /> [[Image:F3.large.jpg|thumb|400px|left|GIP-induced Pathway.&lt;ref&gt;PMID:12475913&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1329850 2011-12-09T19:13:08Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function===<br /> The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;.<br /> <br /> [[Image:F3.large.jpg|thumb|400px|left|GIP-induced Pathway.&lt;ref&gt;PMID:12475913&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1329849 2011-12-09T19:12:34Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function===<br /> The purpose of the receptor is to bind glucose-dependent insulinotropic polypeptide (GIP) in the presence of glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors, which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;. One such example is glucagon-like peptide-1 (GLP-1), which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta.<br /> <br /> [[Image:F3.large.jpg|thumb|400px|left|GIP-induced Pathway.&lt;ref&gt;PMID:12475913&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327557 2011-12-02T21:20:36Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is Glucagon-like peptide-1 (GLP-1) which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. The benefit of synthetic GLP-1 is that it is not protein and so would not be degraded as easily therefore prolonging the benefits of the drug. One such example is Byetta&lt;ref&gt;&quot;Byetta.&quot; BYETTA (exenatide) Injection | Welcome to BYETTA.com. Amylin Pharmaceuticals, Inc., 2011. Web. 02 Dec. 2011. &lt;http://www.byetta.com/Pages/index.aspx&gt;&lt;/ref&gt;.<br /> <br /> [[Image:F3.large.jpg |400px| |left| |caption=&lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;|]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327554 2011-12-02T21:15:01Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. Incretins are a class of biological molecules that act like gastrointestinal hormones. One such example is Glucagon-like peptide-1 (GLP-1) which works with GIP to regulate the body's insulin levels. Synthetic versions of this peptide hormone have been made to treat people with type-2 diabetes. It works by stimulating GIP production as well as insulin secretion causing the body to properly regulate its blood glucose levels like someone without diabetes. <br /> <br /> [[Image:F3.large.jpg |400px| |left| |caption=&lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;|]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327550 2011-12-02T20:56:04Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left| |caption=&lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;|]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327549 2011-12-02T20:55:35Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left| caption=&lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327548 2011-12-02T20:55:19Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left| cation=&lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327547 2011-12-02T20:54:47Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> <br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left| &lt;ref&gt;&quot;A Novel Pathway for Regulation of Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor Expression in ß Cells.&quot; The FASEB Journal 17.1 (2003): 91-93. Print.&lt;/ref&gt;]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327303 2011-11-30T21:55:37Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> <br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327302 2011-11-30T21:53:28Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327301 2011-11-30T21:52:55Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='' scene='Sandbox_Reserved_384/Standard_scene/1&gt;Glucose-dependant insulinotropic polypeptide receptor&lt;/scene&gt;' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327300 2011-11-30T21:52:14Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='' scene='&lt;scene name='Sandbox_Reserved_384/Standard_scene/1'&gt;Glucose-dependant insulinotropic polypeptide receptor&lt;/scene&gt;' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327299 2011-11-30T21:49:40Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='&lt;scene name='Sandbox_Reserved_384/Standard_scene/1'&gt;TextToBeDisplayed&lt;/scene&gt;' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though &lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327298 2011-11-30T21:47:41Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though&lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327297 2011-11-30T21:47:00Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though&lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions&lt;|brown|/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327296 2011-11-30T21:45:53Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though&lt;scene name='Sandbox_Reserved_384/Hydrophobics/1'&gt;hydrophobic interactions |brown|&lt;/scene&gt; and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327295 2011-11-30T21:19:17Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> =Glucose-dependent Insulinotropic Polypeptide Receptor=<br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Ongoing Research===<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327294 2011-11-30T20:58:56Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.&lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ==Ongoing Research==<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> ===References=== <br /> <br /> &lt;references /&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327293 2011-11-30T20:57:53Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. &lt;ref&gt;PMID:11334402&lt;/ref&gt;<br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<br /> <br /> ==Ongoing Research==<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327292 2011-11-30T20:55:01Z

<p>Logan Brushart: /* Molecular Function */</p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The purpose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. This occurs in the pancreatic islet beta-cells. It is likely that the cause of type 2 diabetes is due to the inability of GIP to bind properly to GIPR.<br /> <br /> ==Ongoing Research==<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327275 2011-11-30T19:09:01Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> ==Ongoing Research==<br /> The significance of this receptor makes it a prime target for diabetes research. <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327274 2011-11-30T19:06:58Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |400px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327273 2011-11-30T19:06:39Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |300px| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327272 2011-11-30T19:05:18Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |thumb| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327271 2011-11-30T19:04:46Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg size='100' |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327270 2011-11-30T19:04:27Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |size='100'| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327269 2011-11-30T19:04:09Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |size='400'| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327268 2011-11-30T19:03:39Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |thumb| |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=File:F3.large.jpg&diff=1327267 2011-11-30T19:02:45Z

<p>Logan Brushart: </p> <hr /> <div>http://www.fasebj.org/content/17/1/91/F3.expansion.html</div>

Logan Brushart https://proteopedia.org/index.php?title=File:F3.large.jpg&diff=1327266 2011-11-30T19:02:28Z

<p>Logan Brushart: </p> <hr /> <div></div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327265 2011-11-30T19:00:57Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> <br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules. GIP binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increased secretion of insulin. <br /> <br /> [[Image:F3.large.jpg |left|]]<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Guanine_riboswitch&diff=1327264 2011-11-30T18:56:28Z

<p>Logan Brushart: </p> <hr /> <div>&lt;Structure load='1Y27' size='400' frame='true' align='right' caption='Guanine-Riboswitch-Guanine complex' scene='Insert optional scene name here' /&gt;<br /> '''<br /> == Guanine Riboswitch ==<br /> '''<br /> Riboswitches are highly conserved metabolite binding domains that are present in the 5'-untranslated region (5'-UTR) of certain mRNAs in bacteria which can act in the absence of protein cofactors. Riboswitches have been found to be broadly distributed among all forms of life, but all most frequently found in bacteria. These structural elements bind specific metabolites in the aptamer (binding site) domain that results in allosteric rearrangement in the adjacent expression platform that interacts with RNA elements to regulate gene expression associated with biosythesis and transport. In bacteria, riboswitches account for the regulation of 2% of the genes, thus making them attractive for genetic research.<br /> Within the bacterium, ''Bacillus subtilus'', the guanine riboswitch is found. The &lt;scene name='Sandbox_Reserved_402/Initial_structure_with_bases/2'&gt;guanine riboswitch&lt;/scene&gt; operates by the binding of a guanine, hypoxanthine, or xanthine to the aptamer domain. Through allosteric effects the aptamer then changes the conformation of the expression platform which results in the premature termination of transcription. Thus, the guanine riboswitch has two distinct conformations in which it operates: a metabolite bound and metabolite-free folds, involving the alternative base-pairing of the regulatory RNA region.&lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> == Riboswitch Structure ==<br /> The guanine riboswitch is comprised of three helices which are labeled P1, P2, and P3 which connect to form a junction. It is within this junction that ligand binding occurs. When the g-riboswitch-guanine complex is formed the kissing interactions of two hairpin loops force P2 and P3 to align in a parallel fashion and form hydrogen bonds. The &lt;scene name='Sandbox_Reserved_402/Binding_site/2'&gt;ligand&lt;/scene&gt; is bound to the junction within the guanine riboswitch via several hydrogen bonds to nucleotides U22, U47, U51, C74. Due to the compactness of the binding site the ligand must utilize the induced-fit binding mechanism. &lt;ref&gt;PMID: 17175531 &lt;/ref&gt;<br /> <br /> <br /> <br /> == Regulation Mechanism ==<br /> <br /> Metabolite-binding riboswitches are triggered if a high concentration of the metabolite is present within the cell. Under these conditions, the metabolite will interact with the aptamer domain, with high affinity and selectivity, which will then stabilize the metabolite bound fold in the nascent RNA, and in so doing prevents the formation of the metabolite-free fold. This typically results in the stabilization or disruption of a regulatory hairpin, which prematurely terminates transcription or sequesters the ribosome-binding site, thereby regulating gene expression. In the absence of the metabolite when the 5’-UTR is transcribed the riboswitch folds into the metabolite-free fold which does not interfere with the expression of the adjacent open reading frame.<br /> In Bacillus subtilis, the 5'-UTR of xpt-pbuX mRNA binds guanine with high precision to down regulate the expression of genes by forming transcription terminator structures. Due to the mechanism and function of riboswitches, they are an attractive target for drug development. &lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> <br /> == References ==<br /> <br /> <br /> &lt;references/&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327262 2011-11-30T18:54:29Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox reserved 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also known as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. <br /> [[Image:F3.small.jpg |left| ]]<br /> ===Molecular Function=== <br /> The prupose of the receptor is to bind Glucose-dependent insulinotropic polypeptide (GIP) in the presence of Glucose. This causes a chain reaction that increases secretion of insulin molecules.It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> <br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Sandbox_Reserved_384&diff=1327260 2011-11-30T18:45:06Z

<p>Logan Brushart: </p> <hr /> <div>&lt;!-- PLEASE DO NOT DELETE THIS TEMPLATE --&gt;<br /> {{Sandbox_Reserved_JMeans}}<br /> &lt;!-- PLEASE ADD YOUR CONTENT BELOW HERE --&gt;<br /> <br /> *[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> [[Image:F3.small.jpg]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1327259 2011-11-30T18:45:01Z

<p>Logan Brushart: </p> <hr /> <div>Senior Biology Student at University of Rio Grande<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325094 2011-11-30T02:31:41Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> [[Image:F3.small.jpg]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325093 2011-11-30T02:29:57Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> {{Clear}}<br /> [[2qkh]]<br /> <br /> [[Image:F3.large.jpg]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325090 2011-11-30T02:12:27Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325089 2011-11-30T02:11:48Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose. It binds to GIPR though hydrophobic interactions and causes the release of G protein-coupled receptors which in turn results causes an enzymatic cascade resulting in the increase secretion of insulin. <br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325088 2011-11-30T02:01:57Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets binded in several locations with disulfide bonds within itself. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose.<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325086 2011-11-30T02:00:43Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) consisting of an alpha helix and beta sheets binded with disulfide bonds. The ligand which binds to GIPR is Glucose-dependent insulinotropic polypeptide (GIP) also know as Gastric inhibitory polypeptide(shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose.<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325084 2011-11-30T01:55:31Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) which binds to its ligand, Glucose-dependent insulinotropic polypeptide (GIP) (shown in green). GIP is an alpha helical endogenous polypeptide hormone which is released upon the ingestion of food, specifically the carbohydrate glucose.<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Guanine_riboswitch&diff=1325082 2011-11-30T01:54:15Z

<p>Logan Brushart: </p> <hr /> <div><br /> &lt;Structure load='1Y27' size='400' frame='true' align='right' caption='Guanine-Riboswitch-Guanine complex' scene='Insert optional scene name here' /&gt;<br /> '''<br /> == Guanine Riboswitch ==<br /> '''<br /> Riboswitches are highly conserved metabolite binding domains that are present in the 5'-untranslated region (5'-UTR) of certain mRNAs in bacteria which can act in the absence of protein cofactors. Riboswitches have been found to be broadly distributed among all forms of life, but all most frequently found in bacteria. These structural elements bind specific metabolites in the aptamer (binding site) domain that results in allosteric rearrangement in the adjacent expression platform that interacts with RNA elements to regulate gene expression associated with biosythesis and transport. In bacteria, riboswitches account for the regulation of 2% of the genes, thus making them attractive for genetic research.<br /> Within the bacterium, ''Bacillus subtilus'', the guanine riboswitch is found. The &lt;scene name='Sandbox_Reserved_402/Initial_structure_with_bases/2'&gt;guanine riboswitch&lt;/scene&gt; operates by the binding of a guanine, hypoxanthine, or xanthine to the aptamer domain. Through allosteric effects the aptamer then changes the conformation of the expression platform which results in the premature termination of transcription. Thus, the guanine riboswitch has two distinct conformations in which it operates: a metabolite bound and metabolite-free folds, involving the alternative base-pairing of the regulatory RNA region.&lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> == Riboswitch Structure ==<br /> The guanine riboswitch is comprised of three helices which are labeled P1, P2, and P3 which connect to form a junction. It is within this junction that ligand binding occurs. When the g-riboswitch-guanine complex is formed the kissing interactions of two hairpin loops force P2 and P3 to align in a parallel fashion and form hydrogen bonds. The &lt;scene name='Sandbox_Reserved_402/Binding_site/2'&gt;ligand&lt;/scene&gt; is bound to the junction within the guanine riboswitch via several hydrogen bonds to nucleotides U22, U47, U51, C74. Due to the compactness of the binding site the ligand must utilize the induced-fit binding mechanism. &lt;ref&gt;PMID: 17175531 &lt;/ref&gt;<br /> <br /> <br /> <br /> == Regulation Mechanism ==<br /> <br /> Metabolite-binding riboswitches are triggered if a high concentration of the metabolite is present within the cell. Under these conditions, the metabolite will interact with the aptamer domain, with high affinity and selectivity, which will then stabilize the metabolite bound fold in the nascent RNA, and in so doing prevents the formation of the metabolite-free fold. This typically results in the stabilization or disruption of a regulatory hairpin, which prematurely terminates transcription or sequesters the ribosome-binding site, thereby regulating gene expression. In the absence of the metabolite when the 5’-UTR is transcribed the riboswitch folds into the metabolite-free fold which does not interfere with the expression of the adjacent open reading frame.<br /> In Bacillus subtilis, the 5'-UTR of xpt-pbuX mRNA binds guanine with high precision to down regulate the expression of genes by forming transcription terminator structures. Due to the mechanism and function of riboswitches, they are an attractive target for drug development. &lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> <br /> == References ==<br /> <br /> <br /> &lt;references/&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325079 2011-11-30T01:48:14Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in blue) which binds to its ligand, Glucose-dependent insulinotropic polypeptide (GIP) (shown in green).<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325078 2011-11-30T01:46:35Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration. The receptor in a multispan membrane bound protein (shown in grey) which binds to its ligand Glucose-dependent insulinotropic polypeptide (GIP)(shown in green).<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart https://proteopedia.org/index.php?title=Guanine_riboswitch&diff=1325075 2011-11-30T01:39:38Z

<p>Logan Brushart: </p> <hr /> <div><br /> <br /> &lt;Structure load='1Y27' size='400' frame='true' align='right' caption='Guanine-Riboswitch-Guanine complex' scene='Insert optional scene name here' /&gt;<br /> '''<br /> == Guanine Riboswitch ==<br /> '''<br /> Riboswitches are highly conserved metabolite binding domains that are present in the 5'-untranslated region (5'-UTR) of certain mRNAs in bacteria which can act in the absence of protein cofactors. Riboswitches have been found to be broadly distributed among all forms of life, but all most frequently found in bacteria. These structural elements bind specific metabolites in the aptamer (binding site) domain that results in allosteric rearrangement in the adjacent expression platform that interacts with RNA elements to regulate gene expression associated with biosythesis and transport. In bacteria, riboswitches account for the regulation of 2% of the genes, thus making them attractive for genetic research.<br /> Within the bacterium, ''Bacillus subtilus'', the guanine riboswitch is found. The &lt;scene name='Sandbox_Reserved_402/Initial_structure_with_bases/2'&gt;guanine riboswitch&lt;/scene&gt; operates by the binding of a guanine, hypoxanthine, or xanthine to the aptamer domain. Through allosteric effects the aptamer then changes the conformation of the expression platform which results in the premature termination of transcription. Thus, the guanine riboswitch has two distinct conformations in which it operates: a metabolite bound and metabolite-free folds, involving the alternative base-pairing of the regulatory RNA region.&lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> == Riboswitch Structure ==<br /> The guanine riboswitch is comprised of three helices which are labeled P1, P2, and P3 which connect to form a junction. It is within this junction that ligand binding occurs. When the g-riboswitch-guanine complex is formed the kissing interactions of two hairpin loops force P2 and P3 to align in a parallel fashion and form hydrogen bonds. The &lt;scene name='Sandbox_Reserved_402/Binding_site/2'&gt;ligand&lt;/scene&gt; is bound to the junction within the guanine riboswitch via several hydrogen bonds to nucleotides U22, U47, U51, C74. Due to the compactness of the binding site the ligand must utilize the induced-fit binding mechanism. &lt;ref&gt;PMID: 17175531 &lt;/ref&gt;<br /> <br /> <br /> <br /> == Regulation Mechanism ==<br /> <br /> Metabolite-binding riboswitches are triggered if a high concentration of the metabolite is present within the cell. Under these conditions, the metabolite will interact with the aptamer domain, with high affinity and selectivity, which will then stabilize the metabolite bound fold in the nascent RNA, and in so doing prevents the formation of the metabolite-free fold. This typically results in the stabilization or disruption of a regulatory hairpin, which prematurely terminates transcription or sequesters the ribosome-binding site, thereby regulating gene expression. In the absence of the metabolite when the 5’-UTR is transcribed the riboswitch folds into the metabolite-free fold which does not interfere with the expression of the adjacent open reading frame.<br /> In Bacillus subtilis, the 5'-UTR of xpt-pbuX mRNA binds guanine with high precision to down regulate the expression of genes by forming transcription terminator structures. Due to the mechanism and function of riboswitches, they are an attractive target for drug development. &lt;ref&gt;PMID: 15610857 &lt;/ref&gt;<br /> <br /> <br /> <br /> == References ==<br /> <br /> <br /> &lt;references/&gt;</div>

Logan Brushart https://proteopedia.org/index.php?title=User:Logan_Brushart&diff=1325072 2011-11-30T01:29:52Z

<p>Logan Brushart: </p> <hr /> <div>*[[User:LoganBrushart/Sandbox 384]]<br /> &lt;Structure load='2qkh' size='400' frame='true' align='right' caption='Glucose-dependant insulinotropic polypeptide receptor, [[2qkh]]' scene='' /&gt;<br /> &lt;!--<br /> {{STRUCTURE_2qkh| PDB=2qkh | SIZE=400| SCENE= |right|CAPTION=Glucose-dependent insulinotropic polypeptide receptor, [[2qkh]] }}<br /> --&gt;<br /> <br /> ==Background==<br /> two men walk into a bar. The first man says to the bartender &quot;I'll have some H2O.&quot; The second man says &quot;That sounds good, I'll have some H2O too.&quot;<br /> The second man died.<br /> ===About The Receptor===<br /> Glucose-dependent insulinotropic polypeptide receptor (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules, GIPR is expressed in higher levels when glucose is in higher concentration.<br /> {{Clear}}<br /> [[2qkh]]</div>

Logan Brushart