'''2009 H1N1 swine flu genome and protein analysis'''

This page was created by Michael Strong, other contributers include ...

[[User:Michael_Strong|home]] • [[User:Michael_Strong/H1N1|H1N1]] • [[User:Michael_Strong/H1N1/PB2|PB2]]• [[User:Michael_Strong/H1N1/PB1|PB1]]• [[User:Michael_Strong/H1N1/PA|PA]] • [[User:Michael_Strong/H1N1/HA|HA]] • [[User:Michael_Strong/H1N1/NP|NP]] • [[User:Michael_Strong/H1N1/NA|NA]] • [[User:Michael_Strong/H1N1/MP|MP]] • [[User:Michael_Strong/H1N1/NS|NS]]

Shown below are Clustal Multiple Sequence Alignmnents of the Protein Sequences from five strains of the recent 2009 H1N1 Swine Influenza Virus, including isolates from Mexico, California, Texas, New York, and Canada. Protein sequences obtained from: http://www.ncbi.nlm.nih.gov/genomes/FLU/SwineFlu.html. Multiple sequence alignments of the PB2, PB1, PA, HA, NP, NA, MP, and NS proteins are provided.
== PB2 Protein Structural Homolgy Model ==

<applet load='MPB21.pdb' size='300' frame='true' align='center' caption='PB2 Homology Model, Mexico Strain, [http://www.ncbi.nlm.nih.gov/nuccore/FJ998206 A/Mexico/InDRE4487/2009 PB2], residues 535-742, 95% sequence identity to pdp template [http://proteopedia.org/wiki/index.php/3cw4 3cw4]' scene ='User:Michael_Strong/H1N1/PB2/MSA/1/1' />

=== PB2 Sequence Polymorphisms ===

{| class="wikitable"
|Protein
|Polymorphism
|Strain with Polymorphism
|Number of Strains with Polymorphism
|----
|PB2
|I30V
|gi|229892696_A/Canada-AB/RV153
|1
|----
|PB2
|N82S
|gi|229484025_A/Mexico/InDRE448
|all others
|----
|PB2
|H151Q
|gi|237624321_A/swine/Alberta/O
|1
|----
|PB2
|D161N
|gi|227831783_A/California/06/2
|1
|----
|PB2
|V267I
|gi|229783414_A/New_York/1682/2
|1
|----
|PB2
|S324R
|gi|237624321_A/swine/Alberta/O
|1
|----
|PB2
|H432Y
|gi|237624321_A/swine/Alberta/O
|1
|----
|PB2
|L464M
|gi|229892692_A/Mexico/InDRE411
|1
|----
|PB2
|K526R
|gi|229892698_A/Canada-NS/RV153
|5
|----
|PB2
|G698D
|gi|227831783_A/California/06/2
|1
|<scene name='User:Michael_Strong/H1N1/PB2/MSA/2/1'>G698</scene>
|----
|}

== PA Structure ==

<applet load='MSPA1.pdb' size='300' frame='true' align='center' caption='PA Homology Model, Mexico Strain, A/Mexico/InDRE4487/2009, residues 257-716, 97% sequence identity to pdp template [http://proteopedia.org/wiki/index.php/3cm8 3cm8]' scene ='User:Michael_Strong/H1N1/PA/MSA/1/1'/>

=== PA Polymorphisms ===

{| class="wikitable"
|Protein
|Polymorphism
|Strain with Polymorphism
|Number of Strains with Polymorphism
|----
|PA
|S224P
|gi|227977170_A/California/07/2
|6
|----
|PA
|R269K
|gi|229484063_A/Canada-NS/RV153
|2
|<scene name='User:Michael_Strong/H1N1/PA/MSA/269/2'>269</scene>
|----
|PA
|L275I
|gi|229484065_A/Mexico/InDRE448
|all others
|<scene name='User:Michael_Strong/H1N1/PA/MSA/275/3'>275</scene>
|----
|PA
|M581L
|gi|237511889_A/Mexico/4108/200
|11
|<scene name='User:Michael_Strong/H1N1/PA/MSA/581/2'>581</scene>
|----
|PA
|L702P
|gi|237624325_A/swine/Alberta/O
|1
|<scene name='User:Michael_Strong/H1N1/PA/MSA/702/1'>702</scene>
|----
|}

===multiple sequence alignment of PB2===

CLUSTAL 2.0.10 multiple sequence alignment

--------------------
'''PB2'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of PB2

A/California/04/2009 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM 50
A/New_York/18/2009 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM 50
A/Canada-ON/RV1527/2009 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM 50
A/Texas/09/2009 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM 50
A/Mexico/InDRE4487/2009 MERIKELRDLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWM 50
**************************************************

A/California/04/2009 MAMRYPITADKRIMDMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWN 100
A/New_York/18/2009 MAMRYPITADKRIMDMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWN 100
A/Canada-ON/RV1527/2009 MAMRYPITADKRIMDMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWN 100
A/Texas/09/2009 MAMRYPITADKRIMDMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWN 100
A/Mexico/InDRE4487/2009 MAMRYPITADKRIMDMIPERNEQGQTLWSKTSDAGSDRVMVSPLAVTWWN 100
*******************************.******************

A/California/04/2009 RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDTNPG 150
A/New_York/18/2009 RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDTNPG 150
A/Canada-ON/RV1527/2009 RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDTNPG 150
A/Texas/09/2009 RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDTNPG 150
A/Mexico/InDRE4487/2009 RNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDTNPG 150
**************************************************

A/California/04/2009 HADLSAKEAQDVIMEVVFPNEVGARILTSESQLAITKEKKEELQDCKIAP 200
A/New_York/18/2009 HADLSAKEAQDVIMEVVFPNEVGARILTSESQLAITKEKKEELQDCKIAP 200
A/Canada-ON/RV1527/2009 HADLSAKEAQDVIMEVVFPNEVGARILTSESQLAITKEKKEELQDCKIAP 200
A/Texas/09/2009 HADLSAKEAQDVIMEVVFPNEVGARILTSESQLAITKEKKEELQDCKIAP 200
A/Mexico/InDRE4487/2009 HADLSAKEAQDVIMEVVFPNEVGARILTSESQLAITKEKKEELQDCKIAP 200
**************************************************

A/California/04/2009 LMVAYMLERELVRKTRFLPVAGGTGSVYIEVLHLTQGTCWEQMYTPGGEV 250
A/New_York/18/2009 LMVAYMLERELVRKTRFLPVAGGTGSVYIEVLHLTQGTCWEQMYTPGGEV 250
A/Canada-ON/RV1527/2009 LMVAYMLERELVRKTRFLPVAGGTGSVYIEVLHLTQGTCWEQMYTPGGEV 250
A/Texas/09/2009 LMVAYMLERELVRKTRFLPVAGGTGSVYIEVLHLTQGTCWEQMYTPGGEV 250
A/Mexico/InDRE4487/2009 LMVAYMLERELVRKTRFLPVAGGTGSVYIEVLHLTQGTCWEQMYTPGGEV 250
**************************************************

A/California/04/2009 RNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGVRMVDILRQ 300
A/New_York/18/2009 RNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGVRMVDILRQ 300
A/Canada-ON/RV1527/2009 RNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGVRMVDILRQ 300
A/Texas/09/2009 RNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGVRMVDILRQ 300
A/Mexico/InDRE4487/2009 RNDDVDQSLIIAARNIVRRAAVSADPLASLLEMCHSTQIGGVRMVDILRQ 300
**************************************************

A/California/04/2009 NPTEEQAVDICKAAIGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQ 350
A/New_York/18/2009 NPTEEQAVDICKAAIGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQ 350
A/Canada-ON/RV1527/2009 NPTEEQAVDICKAAIGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQ 350
A/Texas/09/2009 NPTEEQAVDICKAAIGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQ 350
A/Mexico/InDRE4487/2009 NPTEEQAVDICKAAIGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQ 350
**************************************************

A/California/04/2009 TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIV 400
A/New_York/18/2009 TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIV 400
A/Canada-ON/RV1527/2009 TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIV 400
A/Texas/09/2009 TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIV 400
A/Mexico/InDRE4487/2009 TLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIV 400
**************************************************

A/California/04/2009 AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG 450
A/New_York/18/2009 AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG 450
A/Canada-ON/RV1527/2009 AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG 450
A/Texas/09/2009 AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG 450
A/Mexico/InDRE4487/2009 AMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKVLFQNWG 450
**************************************************

A/California/04/2009 IESIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDR 500
A/New_York/18/2009 IESIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDR 500
A/Canada-ON/RV1527/2009 IESIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDR 500
A/Texas/09/2009 IESIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDR 500
A/Mexico/InDRE4487/2009 IESIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDR 500
**************************************************

A/California/04/2009 FLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTY 550
A/New_York/18/2009 FLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTY 550
A/Canada-ON/RV1527/2009 FLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTY 550
A/Texas/09/2009 FLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTY 550
A/Mexico/InDRE4487/2009 FLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTY 550
**************************************************

A/California/04/2009 QWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPKATRSRYSGFVRTLF 600
A/New_York/18/2009 QWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPKATRSRYSGFVRTLF 600
A/Canada-ON/RV1527/2009 QWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPKATRSRYSGFVRTLF 600
A/Texas/09/2009 QWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPKATRSRYSGFVRTLF 600
A/Mexico/InDRE4487/2009 QWIIRNWEIVKIQWSQDPTMLYNKMEFEPFQSLVPKATRSRYSGFVRTLF 600
**************************************************

A/California/04/2009 QQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGLRILVR 650
A/New_York/18/2009 QQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGLRILVR 650
A/Canada-ON/RV1527/2009 QQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGLRILVR 650
A/Texas/09/2009 QQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGLRILVR 650
A/Mexico/InDRE4487/2009 QQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGLRILVR 650
**************************************************

A/California/04/2009 GNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTSGVESAVLRGFLILGKE 700
A/New_York/18/2009 GNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTSGVESAVLRGFLILGKE 700
A/Canada-ON/RV1527/2009 GNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTSGVESAVLRGFLILGKE 700
A/Texas/09/2009 GNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTSGVESAVLRGFLILGKE 700
A/Mexico/InDRE4487/2009 GNSPVFNYNKATKRLTVLGKDAGALTEDPDEGTSGVESAVLRGFLILGKE 700
**************************************************

A/California/04/2009 DKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA 750
A/New_York/18/2009 DKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA 750
A/Canada-ON/RV1527/2009 DKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA 750
A/Texas/09/2009 DKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA 750
A/Mexico/InDRE4487/2009 DKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA 750
**************************************************

A/California/04/2009 TKRIRMAIN 759
A/New_York/18/2009 TKRIRMAIN 759
A/Canada-ON/RV1527/2009 TKRIRMAIN 759
A/Texas/09/2009 TKRIRMAIN 759
A/Mexico/InDRE4487/2009 TKRIRMAIN 759
*********
</PRE>

--------------------
'''PB1'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of PB1

A/Canada-ON/RV1527/2009 MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS 50
A/Texas/09/2009 MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS 50
A/Mexico/InDRE4487/2009 MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS 50
A/California/04/2009 MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS 50
A/New_York/18/2009 MDVNPTLLFLKIPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS 50
**************************************************

A/Canada-ON/RV1527/2009 EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP 100
A/Texas/09/2009 EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP 100
A/Mexico/InDRE4487/2009 EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP 100
A/California/04/2009 EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP 100
A/New_York/18/2009 EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP 100
**************************************************

A/Canada-ON/RV1527/2009 GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF 150
A/Texas/09/2009 GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF 150
A/Mexico/InDRE4487/2009 GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF 150
A/California/04/2009 GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF 150
A/New_York/18/2009 GIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF 150
**************************************************

A/Canada-ON/RV1527/2009 RSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMV 200
A/Texas/09/2009 RSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMV 200
A/Mexico/InDRE4487/2009 RSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMV 200
A/California/04/2009 RSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMV 200
A/New_York/18/2009 RSNGLTANESGRLIDFLKDVMESMNKEEIEITTHFQRKRRVRDNMTKKMV 200
**************************************************

A/Canada-ON/RV1527/2009 TQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG 250
A/Texas/09/2009 TQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG 250
A/Mexico/InDRE4487/2009 TQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG 250
A/California/04/2009 TQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG 250
A/New_York/18/2009 TQRTIGKKKQRLNKRGYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG 250
**************************************************

A/Canada-ON/RV1527/2009 FVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISF 300
A/Texas/09/2009 FVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISF 300
A/Mexico/InDRE4487/2009 FVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISF 300
A/California/04/2009 FVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISF 300
A/New_York/18/2009 FVYFVETLARSICEKLEQSGLPVGGNEKKAKLANVVRKMMTNSQDTEISF 300
**************************************************

A/Canada-ON/RV1527/2009 TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMAR 350
A/Texas/09/2009 TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMAR 350
A/Mexico/InDRE4487/2009 TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMAR 350
A/California/04/2009 TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMAR 350
A/New_York/18/2009 TITGDNTKWNENQNPRMFLAMITYITRNQPEWFRNILSMAPIMFSNKMAR 350
**************************************************

A/Canada-ON/RV1527/2009 LGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGT 400
A/Texas/09/2009 LGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGT 400
A/Mexico/InDRE4487/2009 LGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGT 400
A/California/04/2009 LGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGT 400
A/New_York/18/2009 LGKGYMFESKRMKIRTQIPAEMLASIDLKYFNESTKKKIEKIRPLLIDGT 400
**************************************************

A/Canada-ON/RV1527/2009 ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALI 450
A/Texas/09/2009 ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALI 450
A/Mexico/InDRE4487/2009 ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALI 450
A/California/04/2009 ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALI 450
A/New_York/18/2009 ASLSPGMMMGMFNMLSTVLGVSILNLGQKKYTKTIYWWDGLQSSDDFALI 450
**************************************************

A/Canada-ON/RV1527/2009 VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYG 500
A/Texas/09/2009 VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYG 500
A/Mexico/InDRE4487/2009 VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYG 500
A/California/04/2009 VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYG 500
A/New_York/18/2009 VNAPNHEGIQAGVDRFYRTCKLVGINMSKKKSYINKTGTFEFTSFFYRYG 500
**************************************************

A/Canada-ON/RV1527/2009 FVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQL 550
A/Texas/09/2009 FVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQL 550
A/Mexico/InDRE4487/2009 FVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQL 550
A/California/04/2009 FVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQL 550
A/New_York/18/2009 FVANFSMELPSFGVSGVNESADMSIGVTVIKNNMINNDLGPATAQMALQL 550
**************************************************

A/Canada-ON/RV1527/2009 FIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYN 600
A/Texas/09/2009 FIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYN 600
A/Mexico/InDRE4487/2009 FIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYN 600
A/California/04/2009 FIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYN 600
A/New_York/18/2009 FIKDYRYTYRCHRGDTQIQTRRSFELKKLWDQTQSKVGLLVSDGGPNLYN 600
**************************************************

A/Canada-ON/RV1527/2009 IRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHG 650
A/Texas/09/2009 IRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHG 650
A/Mexico/InDRE4487/2009 IRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHG 650
A/California/04/2009 IRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHG 650
A/New_York/18/2009 IRNLHIPEVCLKWELMDDDYRGRLCNPLNPFVSHKEIDSVNNAVVMPAHG 650
**************************************************

A/Canada-ON/RV1527/2009 PAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFF 700
A/Texas/09/2009 PAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFF 700
A/Mexico/InDRE4487/2009 PAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFF 700
A/California/04/2009 PAKSMEYDAVATTHSWIPKRNRSILNTSQRGILEDEQMYQKCCNLFEKFF 700
A/New_York/18/2009 PAKSMEYDAVATTHSWIPKRNRSILNTNQRGILEDEQMYQKCCNLFEKFF 700
***************************.**********************

A/Canada-ON/RV1527/2009 PSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTI 750
A/Texas/09/2009 PSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTI 750
A/Mexico/InDRE4487/2009 PSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTI 750
A/California/04/2009 PSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTI 750
A/New_York/18/2009 PSSSYRRPVGISSMVEAMVSRARIDARVDFESGRIKKEEFSEIMKICSTI 750
**************************************************

A/Canada-ON/RV1527/2009 EELRRQK 757
A/Texas/09/2009 EELRRQK 757
A/Mexico/InDRE4487/2009 EELRRQK 757
A/California/04/2009 EELRRQK 757
A/New_York/18/2009 EELRRQK 757
*******
</PRE>

--------------------
'''PA'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of PA

A/Canada-ON/RV1527/2009 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD 50
A/Texas/09/2009 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD 50
A/Mexico/InDRE4487/2009 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD 50
A/New_York/18/2009 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD 50
A/California/04/2009 MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFMYSD 50
**************************************************

A/Canada-ON/RV1527/2009 FHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGV 100
A/Texas/09/2009 FHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGV 100
A/Mexico/InDRE4487/2009 FHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGV 100
A/New_York/18/2009 FHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGV 100
A/California/04/2009 FHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSICNTTGV 100
**************************************************

A/Canada-ON/RV1527/2009 EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF 150
A/Texas/09/2009 EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF 150
A/Mexico/InDRE4487/2009 EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF 150
A/New_York/18/2009 EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF 150
A/California/04/2009 EKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSF 150
**************************************************

A/Canada-ON/RV1527/2009 TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEET 200
A/Texas/09/2009 TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEET 200
A/Mexico/InDRE4487/2009 TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEET 200
A/New_York/18/2009 TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEET 200
A/California/04/2009 TGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSERGEET 200
**************************************************

A/Canada-ON/RV1527/2009 IEEKFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMS 250
A/Texas/09/2009 IEEKFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMS 250
A/Mexico/InDRE4487/2009 IEEKFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMS 250
A/New_York/18/2009 IEEKFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMS 250
A/California/04/2009 IEEKFEITGTMRKLADQSLPPNFPSLENFRAYVDGFEPNGCIEGKLSQMS 250
***********************.**************************

A/Canada-ON/RV1527/2009 KEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGE 300
A/Texas/09/2009 KEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGE 300
A/Mexico/InDRE4487/2009 KEVNAKIEPFLRTTPRPLRLPDGPICHQRSKFLLMDALKLSIEDPSHEGE 300
A/New_York/18/2009 KEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGE 300
A/California/04/2009 KEVNAKIEPFLRTTPRPLRLPDGPLCHQRSKFLLMDALKLSIEDPSHEGE 300
************************:*************************

A/Canada-ON/RV1527/2009 GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIEN 350
A/Texas/09/2009 GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIEN 350
A/Mexico/InDRE4487/2009 GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIEN 350
A/New_York/18/2009 GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIEN 350
A/California/04/2009 GIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLMAWKQVLAELQDIEN 350
**************************************************

A/Canada-ON/RV1527/2009 EEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEP 400
A/Texas/09/2009 EEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEP 400
A/Mexico/InDRE4487/2009 EEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEP 400
A/New_York/18/2009 EEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEP 400
A/California/04/2009 EEKIPRTKNMKRTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPEP 400
**************************************************

A/Canada-ON/RV1527/2009 RSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV 450
A/Texas/09/2009 RSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV 450
A/Mexico/InDRE4487/2009 RSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV 450
A/New_York/18/2009 RSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV 450
A/California/04/2009 RSLASWVQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTAEV 450
**************************************************

A/Canada-ON/RV1527/2009 SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL 500
A/Texas/09/2009 SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL 500
A/Mexico/InDRE4487/2009 SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL 500
A/New_York/18/2009 SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL 500
A/California/04/2009 SHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNL 500
**************************************************

A/Canada-ON/RV1527/2009 YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL 550
A/Texas/09/2009 YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL 550
A/Mexico/InDRE4487/2009 YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL 550
A/New_York/18/2009 YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL 550
A/California/04/2009 YGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLL 550
**************************************************

A/Canada-ON/RV1527/2009 RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES 600
A/Texas/09/2009 RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES 600
A/Mexico/InDRE4487/2009 RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES 600
A/New_York/18/2009 RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES 600
A/California/04/2009 RTAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAES 600
**************************************************

A/Canada-ON/RV1527/2009 SVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLY 650
A/Texas/09/2009 SVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLY 650
A/Mexico/InDRE4487/2009 SVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLY 650
A/New_York/18/2009 SVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLY 650
A/California/04/2009 SVKEKDMTKEFFENKSETWPIGESPRGVEEGSIGKVCRTLLAKSVFNSLY 650
**************************************************

A/Canada-ON/RV1527/2009 ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV 700
A/Texas/09/2009 ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV 700
A/Mexico/InDRE4487/2009 ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV 700
A/New_York/18/2009 ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV 700
A/California/04/2009 ASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWV 700
**************************************************

A/Canada-ON/RV1527/2009 LLNASWFNSFLTHALK 716
A/Texas/09/2009 LLNASWFNSFLTHALK 716
A/Mexico/InDRE4487/2009 LLNASWFNSFLTHALK 716
A/New_York/18/2009 LLNASWFNSFLTHALK 716
A/California/04/2009 LLNASWFNSFLTHALK 716
****************

</PRE>

--------------------
'''HA'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of HA

A/Texas/04/2009 MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLL 50
A/Mexico/InDRE4487/2009 MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLL 50
A/New_York/18/2009 MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLL 50
A/Canada-ON/RV1527/2009 MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLL 50
A/California/04/2009 MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLL 50
**************************************************

A/Texas/04/2009 EDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETS 100
A/Mexico/InDRE4487/2009 EDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETS 100
A/New_York/18/2009 EDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETS 100
A/Canada-ON/RV1527/2009 EDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETS 100
A/California/04/2009 EDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETP 100
*************************************************.

A/Texas/04/2009 SSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVT 150
A/Mexico/InDRE4487/2009 SSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVT 150
A/New_York/18/2009 SSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVT 150
A/Canada-ON/RV1527/2009 SSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVT 150
A/California/04/2009 SSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVT 150
**************************************************

A/Texas/04/2009 AACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPS 200
A/Mexico/InDRE4487/2009 AACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPS 200
A/New_York/18/2009 AACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPS 200
A/Canada-ON/RV1527/2009 AACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPS 200
A/California/04/2009 AACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPS 200
**************************************************

A/Texas/04/2009 TSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTL 250
A/Mexico/InDRE4487/2009 TSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTL 250
A/New_York/18/2009 TSADQQSLYQNADAYVFVGTSRYSKKFKPEIAIRPKVRDQEGRMNYYWTL 250
A/Canada-ON/RV1527/2009 TSADQQSLYQNADAYVFVGTSRYSKKFKPEIAIRPKVRDQEGRMNYYWTL 250
A/California/04/2009 TSADQQSLYQNADTYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTL 250
*************:*****:******************************

A/Texas/04/2009 VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK 300
A/Mexico/InDRE4487/2009 VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK 300
A/New_York/18/2009 VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK 300
A/Canada-ON/RV1527/2009 VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK 300
A/California/04/2009 VEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK 300
**************************************************

A/Texas/04/2009 GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAI 350
A/Mexico/InDRE4487/2009 GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAI 350
A/New_York/18/2009 GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAI 350
A/Canada-ON/RV1527/2009 GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAI 350
A/California/04/2009 GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSRGLFGAI 350
*************************************:************

A/Texas/04/2009 AGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVI 400
A/Mexico/InDRE4487/2009 AGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVI 400
A/New_York/18/2009 AGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVI 400
A/Canada-ON/RV1527/2009 AGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVI 400
A/California/04/2009 AGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVI 400
**************************************************

A/Texas/04/2009 EKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER 450
A/Mexico/InDRE4487/2009 EKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER 450
A/New_York/18/2009 EKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER 450
A/Canada-ON/RV1527/2009 EKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER 450
A/California/04/2009 EKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENER 450
**************************************************

A/Texas/04/2009 TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGT 500
A/Mexico/InDRE4487/2009 TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGT 500
A/New_York/18/2009 TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGT 500
A/Canada-ON/RV1527/2009 TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGT 500
A/California/04/2009 TLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGT 500
**************************************************

A/Texas/04/2009 YDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAI 550
A/Mexico/InDRE4487/2009 YDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAI 550
A/New_York/18/2009 YDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAI 550
A/Canada-ON/RV1527/2009 YDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAI 550
A/California/04/2009 YDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAI 550
**************************************************

A/Texas/04/2009 SFWMCSNGSLQCRICI 566
A/Mexico/InDRE4487/2009 SFWMCSNGSLQCRICI 566
A/New_York/18/2009 SFWMCSNGSLQCRICI 566
A/Canada-ON/RV1527/2009 SFWMCSNGSLQCRICI 566
A/California/04/2009 SFWMCSNGSLQCRICI 566
****************
</PRE>

--------------------
'''NP'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of NP

A/California/04/2009 ------MASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMC 44
A/Texas/04/2009 ------MASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMC 44
A/Mexico/InDRE4487/2009 MSDIEAMASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMC 50
A/New_York/18/2009 ------MASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMC 44
A/Canada-ON/RV1527/2009 MSDIEAMASQGTKRSYEQMETGGERQDATEIRASVGRMIGGIGRFYIQMC 50
********************************************

A/California/04/2009 TELKLSDYDGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG 94
A/Texas/04/2009 TELKLSDYDGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG 94
A/Mexico/InDRE4487/2009 TELKLSDYDGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG 100
A/New_York/18/2009 TELKLSDYDGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG 94
A/Canada-ON/RV1527/2009 TELKLSDYDGRLIQNSITIERMVLSAFDERRNKYLEEHPSAGKDPKKTGG 100
**************************************************

A/California/04/2009 PIYRRVDGKWMRELILYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLN 144
A/Texas/04/2009 PIYRRVDGKWMRELILYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLN 144
A/Mexico/InDRE4487/2009 PIYRRVDGKWMRELILYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLN 150
A/New_York/18/2009 PIYRRIDGKWMRELILYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLN 144
A/Canada-ON/RV1527/2009 PIYRRIDGKWMRELILYDKEEIRRVWRQANNGEDATAGLTHIMIWHSNLN 150
*****:********************************************

A/California/04/2009 DATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELI 194
A/Texas/04/2009 DATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELI 194
A/Mexico/InDRE4487/2009 DATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELI 200
A/New_York/18/2009 DATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELI 194
A/Canada-ON/RV1527/2009 DATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTIAMELI 200
**************************************************

A/California/04/2009 RMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRE 244
A/Texas/04/2009 RMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRE 244
A/Mexico/InDRE4487/2009 RMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRE 250
A/New_York/18/2009 RMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRE 244
A/Canada-ON/RV1527/2009 RMIKRGINDRNFWRGENGRRTRVAYERMCNILKGKFQTAAQRAMMDQVRE 250
**************************************************

A/California/04/2009 SRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFERE 294
A/Texas/04/2009 SRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFERE 294
A/Mexico/InDRE4487/2009 SRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFERE 300
A/New_York/18/2009 SRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFERE 294
A/Canada-ON/RV1527/2009 SRNPGNAEIEDLIFLARSALILRGSVAHKSCLPACVYGLAVASGHDFERE 300
**************************************************

A/California/04/2009 GYSLVGIDPFKLLQNSQVVSLMRPNENPAHKSQLVWMACHSAAFEDLRVS 344
A/Texas/04/2009 GYSLVGIDPFKLLQNSQVVSLMRPNENPAHKSQLVWMACHSAAFEDLRVS 344
A/Mexico/InDRE4487/2009 GYSLVGIDPFKLLQNSQVVSLMRPNENPAHKSQLVWMACHSAAFEDLRVS 350
A/New_York/18/2009 GYSLVGIDPFKLLQNSQVVSLMRPNENPAHKSQLVWMACHSAAFEDLRVS 344
A/Canada-ON/RV1527/2009 GYSLVGIDPFKLLQNSQVVSLMRPNENPAHKSQLVWMACHSAAFEDLRVS 350
**************************************************

A/California/04/2009 SFIRGKKVIPRGKLSTRGVQIASNENVETMDSNTLELRSRYWAIRTRSGG 394
A/Texas/04/2009 SFIRGKKVIPRGKLSTRGVQIASNENVETMDSNTLELRSRYWAIRTRSGG 394
A/Mexico/InDRE4487/2009 SFIRGKKVIPRGKLSTRGVQIASNENVETMDSNTLELRSRYWAIRTRSGG 400
A/New_York/18/2009 SFIRGKKVIPRGKLSTRGVQIASNENVETMDSNTLELRSRYWAIRTRSGG 394
A/Canada-ON/RV1527/2009 SFIRGKKVIPRGKLSTRGVQIASNENVETMDSNTLELRSRYWAIRTRSGG 400
**************************************************

A/California/04/2009 NTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFSGNNEGRTSDMRTEV 444
A/Texas/04/2009 NTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFSGNNEGRTSDMRTEV 444
A/Mexico/InDRE4487/2009 NTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFSGNNEGRTSDMRTEV 450
A/New_York/18/2009 NTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFSGNNEGRTSDMRTEV 444
A/Canada-ON/RV1527/2009 NTNQQKASAGQISVQPTFSVQRNLPFERATVMAAFSGNNEGRTSDMRTEV 450
**************************************************

A/California/04/2009 IRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAE 494
A/Texas/04/2009 IRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAE 494
A/Mexico/InDRE4487/2009 IRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAE 500
A/New_York/18/2009 IRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAE 494
A/Canada-ON/RV1527/2009 IRMMESAKPEDLSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAE 500
**************************************************

A/California/04/2009 EYDS 498
A/Texas/04/2009 EYDS 498
A/Mexico/InDRE4487/2009 EYDS 504
A/New_York/18/2009 EYDS 498
A/Canada-ON/RV1527/2009 EYDS 504
****
</PRE>

--------------------
'''NA'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of NA

A/California/04/2009 MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCN 50
A/Texas/04/2009 MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCN 50
A/Mexico/InDRE4487/2009 MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCN 50
A/New_York/18/2009 MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCN 50
A/Canada-ON/RV1527/2009 MNPNQKIITIGSVCMTIGMANLILQIGNIISIWISHSIQLGNQNQIETCN 50
**************************************************

A/California/04/2009 QSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIY 100
A/Texas/04/2009 QSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIY 100
A/Mexico/InDRE4487/2009 QSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIY 100
A/New_York/18/2009 QSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIY 100
A/Canada-ON/RV1527/2009 QSVITYENNTWVNQTYVNISNTNFAAGQSVVSVKLAGNSSLCPVSGWAIY 100
**************************************************

A/California/04/2009 SKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIK 150
A/Texas/04/2009 SKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIK 150
A/Mexico/InDRE4487/2009 SKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIK 150
A/New_York/18/2009 SKDNSIRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIK 150
A/Canada-ON/RV1527/2009 SKDNSIRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIK 150
*****:********************************************

A/California/04/2009 DRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDN 200
A/Texas/04/2009 DRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDN 200
A/Mexico/InDRE4487/2009 DRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDN 200
A/New_York/18/2009 DRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDN 200
A/Canada-ON/RV1527/2009 DRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDN 200
**************************************************

A/California/04/2009 GAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQ 250
A/Texas/04/2009 GAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQ 250
A/Mexico/InDRE4487/2009 GAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQ 250
A/New_York/18/2009 GAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSDGQ 250
A/Canada-ON/RV1527/2009 GAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSDGQ 250
***********************************************:**

A/California/04/2009 ASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN 300
A/Texas/04/2009 ASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN 300
A/Mexico/InDRE4487/2009 ASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN 300
A/New_York/18/2009 ASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN 300
A/Canada-ON/RV1527/2009 ASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSN 300
**************************************************

A/California/04/2009 RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFS 350
A/Texas/04/2009 RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFS 350
A/Mexico/InDRE4487/2009 RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFS 350
A/New_York/18/2009 RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFS 350
A/Canada-ON/RV1527/2009 RPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFS 350
**************************************************

A/California/04/2009 FKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWS 400
A/Texas/04/2009 FKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWS 400
A/Mexico/InDRE4487/2009 FKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWS 400
A/New_York/18/2009 FKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWS 400
A/Canada-ON/RV1527/2009 FKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWS 400
**************************************************

A/California/04/2009 GYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNS 450
A/Texas/04/2009 GYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNS 450
A/Mexico/InDRE4487/2009 GYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNS 450
A/New_York/18/2009 GYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNS 450
A/Canada-ON/RV1527/2009 GYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNS 450
**************************************************

A/California/04/2009 DTVGWSWPDGAELPFTIDK 469
A/Texas/04/2009 DTVGWSWPDGAELPFTIDK 469
A/Mexico/InDRE4487/2009 DTVGWSWPDGAELPFTIDK 469
A/New_York/18/2009 DTVGWSWPDGAELPFTIDK 469
A/Canada-ON/RV1527/2009 DTVGWSWPDGAELPFTIDK 469
*******************
</PRE>

--------------------
'''MP'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of MP

A/California/04/2009 ----TEVETYVLSIIPSGPLKAEIAQRLESVFAGKNTDLEALMEWLKTRP 46
A/Texas/04/2009 MSLLTEVETYVLSIIPSGPLKAEIAQRLESVFAGKNTDLEALMEWLKTRP 50
A/New_York/18/2009 MSLLTEVETYVLSIIPSGPLKAEIAQRLESVFAGKNTDLEALMEWLKTRP 50
A/Mexico/InDRE4487/2009 MSLLTEVETYVLSIIPSGPLKAEIAQRLESVFAGKNTDLEALMEWLKTRP 50
A/Canada-ON/RV1527/2009 MSLLTEVETYVLSIIPSGPLKAEIAQRLESVFAGKNTDLEALMEWLKTRP 50
**********************************************

A/California/04/2009 ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLY 96
A/Texas/04/2009 ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLY 100
A/New_York/18/2009 ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLY 100
A/Mexico/InDRE4487/2009 ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLY 100
A/Canada-ON/RV1527/2009 ILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDRAVKLY 100
**************************************************

A/California/04/2009 KKLKREITFHGAKEVSLSYSTGALASCMGLIYNRMGTVTTEAAFGLVCAT 146
A/Texas/04/2009 KKLKREITFHGAKEVSLSYSTGALASCMGLIYNRMGTVTTEAAFGLVCAT 150
A/New_York/18/2009 KKLKREITFHGAKEVSLSYSTGALASCMGLIYNRMGTVTTEAAFGLVCAT 150
A/Mexico/InDRE4487/2009 KKLKREITFHGAKEVSLSYSTGALASCMGLIYNRMGTVTTEAAFGLVCAT 150
A/Canada-ON/RV1527/2009 KKLKREITFHGAKEVSLSYSTGALASCMGLIYNRMGTVTTEAAFGLVCAT 150
**************************************************

A/California/04/2009 CEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAA 196
A/Texas/04/2009 CEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAA 200
A/New_York/18/2009 CEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAA 200
A/Mexico/InDRE4487/2009 CEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAA 200
A/Canada-ON/RV1527/2009 CEQIADSQHRSHRQMATTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAA 200
**************************************************

A/California/04/2009 EAMEVANQTRQMVHAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQR 246
A/Texas/04/2009 EAMEVANQTRQMVHAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQR 250
A/New_York/18/2009 EAMEVANQTRQMVHAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQR 250
A/Mexico/InDRE4487/2009 EAMEVANQTRQMVHAMRTIGTHPSSSAGLKDDLLENLQAYQKRMGVQMQR 250
A/Canada-ON/RV1527/2009 EAMEVANQTRQMVHAMRTIGTHPSSSTGLKDDLLENLQAYQKRMGVQMQR 250
**************************:***********************

A/California/04/2009 FK 248
A/Texas/04/2009 FK 252
A/New_York/18/2009 FK 252
A/Mexico/InDRE4487/2009 FK 252
A/Canada-ON/RV1527/2009 FK 252
**
</PRE>

--------------------
'''NS'''
<PRE>CLUSTAL 2.0.10 =
multiple sequence alignment of NS

A/California/04/2009 MDSNTMSSFQVDCFLWHIRKRFADNGLGDAPFLDRLRRDQKSLKGRGNTL 50
A/Texas/04/2009 MDSNTMSSFQVDCFLWHIRKRFADNGLGDAPFLDRLRRDQKSLKGRGNTL 50
A/Mexico/InDRE4487/2009 MDSNTMSSFQVDCFLWHIRKRFADNGLGDAPFLDRLRRDQKSLKGRGNTL 50
A/New_York/18/2009 MDSNTMSSFQVDCFLWHIRKRFADNGLGDAPFLDRLRRDQKSLKGRGNTL 50
A/Canada-ON/RV1527/2009 MDSNTMSSFQVDCFLWHIRKRFADNGLGDAPFLDRLRRDQKSLKGRGNTL 50
**************************************************

A/California/04/2009 GLDIETATLVGKQIVEWILKEESSETLRMTIASVPTSRYLSDMTLEEMSR 100
A/Texas/04/2009 GLDIETATLVGKQIVEWILKEESSETLRMTIASVPTSRYLSDMTLEEMSR 100
A/Mexico/InDRE4487/2009 GLDIETATLVGKQIVEWILKEESSETLRMTIASVPTSRYLSDMTLEEMSR 100
A/New_York/18/2009 GLDIETATLVGKQIVEWILKEESSETLRMTIASVPTSRYLSDMTLEEMSR 100
A/Canada-ON/RV1527/2009 GLDIETATLVGKQIVEWILKEESSETLRMTIASVPTSRYLSDMTLEEMSR 100
**************************************************

A/California/04/2009 DWFMLMPRQKIIGPLCVRLDQAIMEKNIVLKANFSVIFNRLETLILLRAF 150
A/Texas/04/2009 DWFMLMPRQKIIGPLCVRLDQAIMEKNIVLKANFSVIFNRLETLILLRAF 150
A/Mexico/InDRE4487/2009 DWFMLMPRQKIIGPLCVRLDQAIMEKNIVLKANFSVIFNRLETLILLRAF 150
A/New_York/18/2009 DWFMLMPRQKIIGPLCVRLDQAVMEKNIVLKANFSVIFNRLETLILLRAF 150
A/Canada-ON/RV1527/2009 DWFMLMPRQKIIGPLCVRLDQAVMEKNIVLKANFSVIFNRLETLILLRAF 150
**********************:***************************

A/California/04/2009 TEEGAIVGEISPLPSLPGHTYEDVKNAVGVLIGGLEWNGNTVRVSENIQR 200
A/Texas/04/2009 TEEGAIVGEISPLPSLPGHTYEDVKNAVGVLIGGLEWNGNTVRVSENIQR 200
A/Mexico/InDRE4487/2009 TEEGAIVGEISPLPSLPGHTYEDVKNAVGVLIGGLEWNGNTVRVSENIQR 200
A/New_York/18/2009 TEEGAIVGEISPLPSLPGHTYEDVKNAVGVLIGGLEWNGNTVRVSENIQR 200
A/Canada-ON/RV1527/2009 TEEGAIVGEISPLPSLPGHTYEDVKNAVGVLIGGLEWNGNTVRVSENIQR 200
**************************************************

A/California/04/2009 FAWRNCDENGRPSLPPEQK 219
A/Texas/04/2009 FAWRNCDENGRPSLPPEQK 219
A/Mexico/InDRE4487/2009 FAWRNCDENGRPSLPPEQK 219
A/New_York/18/2009 FAWRNCDENGRPSLPPEQK 219
A/Canada-ON/RV1527/2009 FAWRNCDENGRPSLPPEQK 219
*******************
</PRE>

User:Michael Strong/H1N1/NS

2009-05-18T22:31:35Z

Michael Strong:

User:Michael Strong/H1N1/MP

2009-05-18T22:30:20Z

Michael Strong: