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https://proteopedia.org/index.php?title=Adenosine_A2A_receptor&diff=2907745
Adenosine A2A receptor
2018-06-05T07:47:42Z
<p>Nina Clavio: </p>
<hr />
<div><StructureSection load='' size='350' side='right' scene='54/540144/Cv/1' caption='Human A2AR (mutant) complex with adenosine [[2ydo]]'><br />
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== Function ==<br />
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'''Adenosine A2A receptor''' (A2AR) is one of the G protein-coupled receptors. The protein uses adenosine as the preferred endogenous agonist and is involved in increasing intracellular cAMP levels.<ref>PMID:21593763</ref><br />
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== Disease ==<br />
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A2AR antagonists are being tested in the treatment of Alzheimer's Disease.<br />
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== Relevance ==<br />
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A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]].<br />
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== Structural highlights ==<br />
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Like other G proteins, <scene name='54/540144/Cv/5'>A2AR has 7 transmembrane helices</scene>. <br />
*<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>. <br />
*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>.<br />
</StructureSection><br />
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== 3D Structures of adenosine A2A receptor ==<br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}<br />
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[[3eml]] – hA2AR/lysozyme + antagonist – human<br /><br />
[[5k2a]], [[5k2b]], [[5k2c]], [[5k2d]] – hA2AR/cytochrome b562 <br /><br />
[[5iu4]], [[5iu7]], [[5iu8]], [[5iua]], [[5iub]] – hA2AR/cytochrome b562 (mutant) + inhibitor<br /><br />
[[4ug2]], [[4uhr]] – hA2AR (mutant) + inhibitor<br /><br />
[[5g53]] – hA2AR + G protein <br /><br />
[[3qak]] – hA2AR/lysozyme + agonist <br /><br />
[[2ydo]] – hA2AR (mutant) + adenosine<br /><br />
[[2ydv]], [[5wf5]], [[5wf6]] – hA2AR (mutant) + agonist<br /><br />
[[3pwh]], [[3rey]], [[3rfm]], [[3uza]], [[3uzc]] – hA2AR (mutant) + antagonist<br /><br />
[[3rfm]] – hA2AR (mutant) + caffeine<br /><br />
[[3vg9]], [[3vga]] – hA2AR (mutant) + antibody<br /><br />
[[5jtb]], [[5nlx]], [[5nm2]], [[5nm4]], [[5uvi]], [[5vra]] – hA2AR/cytochrome b562 <br /><br />
[[5olg]], [[5olh]], [[5olo]], [[5olv]], [[5olz]], [[5om1]], [[5om4]] – hA2AR/cytochrome b562 (mutant) <br /><br />
[[4eiy]] – hA2AR/cytochrome b562 + antagonist <br /><br />
[[5uig]], [[6aqf]] – hA2AR/cytochrome b562 (mutant) + antagonist <br /><br />
[[5mzj]] – hA2AR/cytochrome b562 (mutant) + theophylline <br /><br />
[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br /><br />
[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br /><br />
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== References ==<br />
<references/><br />
[[Category:Topic Page]]</div>
Nina Clavio