Proteopedia - User contributions [en]

Nuclear receptor

2012-09-06T10:41:09Z

Schwarz Benjamin:

''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain, mainly alpha
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
composed of
<scene name='Nuclear_receptor/Nr-lbd-alpha/1'>12 alpha-helices</scene>
arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T09:35:05Z

Schwarz Benjamin:

''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
and composed of 12 alpha-helices arranged in a three layered sandwich, and a <scene name='Nuclear_receptor/Nr-lbd-beta/1'>beta-sheet</scene>.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T09:05:12Z

Schwarz Benjamin:

''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain
<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T09:02:14Z

Schwarz Benjamin:

''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is a globular domain<scene name='Nuclear_receptor/Nr-lbd-/1'>well folded</scene>
and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T08:32:26Z

Schwarz Benjamin:

''the nuclear receptors facts book''
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is completely folded and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T08:29:00Z

Schwarz Benjamin: /* Nuclear Receptor */

As exposed in the nuclear receptors facts book
<ref>Vincent Laudet, Hinrich Gronemeyer,
"The nuclear receptor factsbook",
Publisher Academic Press, 2002,
ISBN 0124377351, 9780124377356
</ref>

== Structure ==

=== DBD (DNA Binding Domain) ===
=== LBD (Ligand Binding Domain) ===
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is completely folded and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

</StructureSection>
<references/>

Nuclear receptor

2012-09-06T08:14:08Z

Schwarz Benjamin:

== Nuclear Receptor ==

=== Structure ===
==== DBD (DNA Binding Domain) ====
==== LBD (Ligand Binding Domain) ====
<StructureSection load='1ie8' size='350' side='right' caption='Structure of the LBD of a VDR (vitamin D receptor) complexed to 1alpha,25(OH)(2)D(3) and the 20-epi analogs(PDB entry [[1ie8]])' scene=''>

The structure of the LBD is strongly conserved throughout the familly of nuclear receptors.
It is completely folded and composed of a beta-sheet, and 12 alpha-helices arranged in a three layered sandwich.

</StructureSection>

Nuclear receptor

2012-09-06T08:07:53Z

Schwarz Benjamin: New page: == Nuclear Receptor == === Structure === ==== DBD (DNA Binding Domain) ==== ==== LBD (Ligand Binding Domain) ==== <StructureSection load='1ie8' size='350' side='right' caption='Structure ...

== Nuclear Receptor ==

=== Structure ===
==== DBD (DNA Binding Domain) ====
==== LBD (Ligand Binding Domain) ====
<StructureSection load='1ie8' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1ie8]])' scene=''>

The LBD of a nuclear receptor has a common three layer sandwich

</StructureSection>