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ISSN 2310-6301 As life is more than 2D, Proteopedia helps to bridge the gap between 3D structure & function of biomacromolecules Proteopedia presents this information in a user-friendly way as a collaborative & free 3D-encyclopedia of proteins & other biomolecules.
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Coronavirus Spike Protein Membrane Fusion by Eric Martz SARS-CoV-2 spike protein "spears" the host membrane with a fusion peptide and drags the virus envelope membrane transmembrane domain close to the host membrane, initiating fusion. This moves the virus RNA genome into the host cell, initiating infection. >>> Visit this page >>>	Structure of Anticancer Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3ß G Atilla-Gocumen, L Di Costanzo, E Meggers. J Biol Inorg Chem. 2010 doi: 10.1007/s00775-010-0699-x A crystal structure of an organometallic half-sandwich ruthenium complex bound to glycogen synthase kinase 3ß (GSK-3ß) reveals that the inhibitor binds to the ATP binding site via an induced fit mechanism utilizing several hydrogen bonds and hydrophobic interactions. Importantly, the metal is not involved in any direct interaction with the protein kinase but fulfills a purely structural role. >>> Visit this I3DC complement >>>	Virus Capsid Geometry The Capsid of a virus is its outer shell or "skin". Viruses have evolved intricate and elegant ways to assemble capsid protein chains into complete, usually spherical capsids, often with icosahedral symmetry. Pictured is an extremely simplified model of a capsid, where a single enlarged atom represents each of the 360 protein chains in the capsid of the Simian Virus 40 (SV40), a member of a group of cancer-causing viruses that has been extensively researched for decades. >>> See more animations and explanation >>>
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