21aw

Crystal structure of Nicotiana benthamiana importin alpha-Cucumber mosaic virus (strain FNY) suppressor of silencing 2b NLS peptide complex

spinqualitylabelsall models 21aw, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 21aw is a 6 chain structure with sequence from Cucumber mosaic virus (strain FNY) and Nicotiana benthamiana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function 2B_CMVFN Multifunctional protein that plays two independent roles: viral suppressor of host RNAi (VSR) and viral inducer of host attractiveness to insect vectors (VIA). Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25380036). May directly interfere with mobile silencing signaling (By similarity). Also inhibits signal transduction by the phytohormone jasmonate, making the infected plant more attractive to aphids, which are the second host to play a role as a dissemination vector. Acts by binding to and inhibiting JAZ degradation in the host (By similarity).[UniProtKB:Q66125]

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