3ux4 | pdb_00003ux4

Crystal structure of the urea channel from the human gastric pathogen Helicobacter pylori

spinqualitylabelsall models 3ux4, resolution 3.26Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ux4 is a 3 chain structure with sequence from Helicobacter pylori J99. The February 2013 RCSB PDB Molecule of the Month feature on Proton-Gated Urea Channel by David Goodsell is 10.2210/rcsb_pdb/mom_2013_2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.26Å Ligands: XP4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function UREI_HELPJ Functions as a specific, H(+)-activated urea channel that increases the rate of urea entry into the cytoplasm, resulting in activation of cytoplasmic urease at acidic medium pH. Is essential for H.pylori gastric survival and colonization. Is necessary for the adaptation of urease activity to the extracellular pH, as in the presence of urea, UreI rapidly enhances the production of ammonia in the extracellular medium when the pH of the medium was decreased to pH5 or below (By similarity). See Also Urease accessory protein

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