4e20

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

spinqualitylabelsall models 4e20, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4e20 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.6Å Ligands: 0MY Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TYK2_MOUSE Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities. See Also Tyrosine kinase 3D structures

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