5wdd

Crystal structure of chicken BOK

spinqualitylabelsall models 5wdd, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wdd is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.799Å Ligands: EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BOK_CHICK May play a role in apoptosis.[UniProtKB:O35425] Publication Abstract from PubMed Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been fully explored in mammals. Our structural analysis of BOK suggests close resemblance to BAX and BAK structures. Notably, Bok(-/-)Bax(-/-)Bak(-/-) animals exhibited more severe defects and died earlier than Bax(-/-)Bak(-/-) mice, implying that BOK has overlapping roles with BAX and BAK during developmental cell death. By analyzing Bok(-/-)Bax(-/-)Bak(-/-) triple-knockout mice whose cells are incapable of undergoing intrinsic apoptosis, we identified tissues that formed well without this process. We provide evidence that necroptosis, pyroptosis, or autophagy does not substantially substitute for the loss of apoptosis. Albeit very rare, unexpected attainment of adult Bok(-/-)Bax(-/-)Bak(-/-) mice suggests that morphogenesis can proceed entirely without apoptosis mediated by these proteins and possibly without cell death in general. Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK.,Ke FFS, Vanyai HK, Cowan AD, Delbridge ARD, Whitehead L, Grabow S, Czabotar PE, Voss AK, Strasser A Cell. 2018 May 17;173(5):1217-1230.e17. doi: 10.1016/j.cell.2018.04.036. PMID:29775594 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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