6ffx

Crystal structure of R. ruber ADH-A, mutant F43H

spinqualitylabelsall models 6ffx, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ffx is a 4 chain structure with sequence from Rhodococcus sp. m8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAD, ZN Gene: BKE56_025765 (Rhodococcus sp. M8) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Laboratory evolution of alcohol dehydrogenase produced enzyme variants with improved turnover numbers with a vicinal 1,2-diol and its corresponding hydroxyketone. Crystal structure and transient kinetics analysis aids in rationalizing the new functions of these variants. Directed Evolution of Alcohol Dehydrogenase for Improved Stereoselective Redox Transformations of 1-Phenylethane-1,2-diol and Its Corresponding Acyloin.,Hamnevik E, Maurer D, Enugala TR, Chu T, Lofgren R, Dobritzsch D, Widersten M Biochemistry. 2018 Feb 2. doi: 10.1021/acs.biochem.8b00055. PMID:29384657 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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