9gci | pdb_00009gci

The crystal structure of beta-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus determined at 1.47 A resolution

spinqualitylabelsall models 9gci, resolution 1.47Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9gci is a 2 chain structure with sequence from Caldicellulosiruptor saccharolyticus DSM 8903. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.47Å Ligands: 1PE, CL, EDO, GOL, PEG, PGE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A4XIG7_CALS8 Publication Abstract from PubMed beta-Glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus (Bgl1) has been denoted as having an attractive catalytic profile for various industrial applications. Bgl1 catalyses the final step of in the decomposition of cellulose, an unbranched glucose polymer that has attracted the attention of researchers in recent years as it is the most abundant renewable source of reduced carbon in the biosphere. With the aim of enhancing the thermostability of Bgl1 for a broad spectrum of biotechnological processes, it has been subjected to structural studies. Crystal structures of Bgl1 and its complex with glucose were determined at 1.47 and 1.95 A resolution, respectively. Bgl1 is a member of glycosyl hydrolase family 1 (GH1 superfamily, EC 3.2.1.21) and the results showed that the 3D structure of Bgl1 follows the overall architecture of the GH1 family, with a classical (beta/alpha)(8) TIM-barrel fold. Comparisons of Bgl1 with sequence or structural homologues of beta-glucosidase reveal quite similar structures but also unique structural features in Bgl1 with plausible functional roles. Structural studies of beta-glucosidase from the thermophilic bacterium Caldicellulosiruptor saccharolyticus.,Sotiropoulou AI, Hatzinikolaou DG, Chrysina ED Acta Crystallogr D Struct Biol. 2024 Oct 1;80(Pt 10):733-743. doi: , 10.1107/S2059798324009252. Epub 2024 Oct 1. PMID:39361356 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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