9lw3 | pdb_00009lw3

TMEM164-substrate

spinqualitylabelsall models 9lw3, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9lw3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3Å Ligands: 4I1, CLR, LPC, PEE, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TM164_HUMAN Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis (PubMed:36782012). Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death (PubMed:35947500).

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