Erythropoietin receptor

spinqualitylabelsall models 2 extracellular domains of Human erythropoietin receptor (green) complex with erythropoietin (magenta) (PDB code 1cn4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Erythropoietin receptor (EpoR) is a cytokine receptor. Upon binding of erythropoietin (Epo), EpoR changes from a monomer to a dimer. This change induces the activation of Jak2 kinase via its autophosphorylation. Specific tyrosines in the intracellular part of EpoR are phosphorylated and activate various cascades of signal transduction which lead to the formation and maturation of red blood cells. See also: Cytokine receptors and Immune receptors Relevance EpoR rescues red blood cells progenitors from apoptosis. Beneficial mutations of EpoR result in increase of red blood cell number and hence better athletic performance. Disease Mutations in EpoR are the cause of erythroleukemia and erythrocytosis. Structural highlights Human erythropoietin receptor with erythropoietin (PDB code 1cn4).

3D Structures of erythropoietin receptor

Updated on 03-June-2025

cytokine receptor – hEpoR extracellular domain 25-249 - human
Cytokine receptors – hEpoR transmembrane domain 237-284 - NMR
Immune receptors, 1cn4 – hEpoR extracellular domain + Epo peptide
1cn4, 1eer – hEpoR extracellular domain (mutant) + Epo (mutant)
2jix, 8vui – hEpoR extracellular domain + antibody
8vvm, 8vvo – hEpoR extracellular domain (mutant) + antibody
4y5x, 4y5v, 4y5y – hEpoR extracellular domain + diabody
6moe, 6moh, 6moj, 6mof, 6moi, 6mok, 6mol – hEpoR extracellular domain + darpin
6mol, 6e2q – hEpoR residues 273-338 + JAK2
2mxb – EpoR transmembrane domain – mouse - NMR

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