Poly (ADP-ribose) glycohydrolase

spinqualitylabelsall models Structure of human poly (ADP-ribose) glycohydrolase catalytic domain complex with ADP-ribose (PDB code 3sig). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Poly (ADP-ribose) glycohydrolase (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers. Relevance PARG deficiency leads to cell death. Over-activation of PARP due to oxidative stress culminates in cell dysfunction and necrosis. PARP inhibitors have anti-inflammatory effect. Structural highlights The active site of PARG contains two catalytic glutamic acid residues. Water molecules are shown as red spheres. 3D Structures of poly (ADP-ribose) glycohydrolase Poly(ADP-ribose) glycohydrolase 3D structures

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