View source for 1ezn


==SOLUTION STRUCTURE OF A DNA THREE-WAY JUNCTION==
<StructureSection load='1ezn' size='340' side='right'caption='[[1ezn]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ezn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EZN FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ezn OCA], [https://pdbe.org/1ezn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ezn RCSB], [https://www.ebi.ac.uk/pdbsum/1ezn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ezn ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of a DNA three-way junction (3H) containing two unpaired thymidine bases at the branch site (3HT2), was determined by NMR. Arms A and B of the 3HT2 form a quasi-continuous stacked helix, which is underwound at the junction and has an increased helical rise. The unstacked arm C forms an acute angle of approximately 55 degrees with the unique arm A. The stacking of the unpaired thymidine bases on arm C resembles the folding of hairpin loops. From this data, combined with the reported stacking behavior of 23 other 3HS2 s, two rules are derived that together correctly reproduce their stacking preference. These rules predict, from the sequence of any 3HS2, its stacking preference. The structure also suggests a plausible mechanism for structure-specific recognition of branched nucleic acids by proteins.

Solution structure of a DNA three-way junction containing two unpaired thymidine bases. Identification of sequence features that decide conformer selection.,van Buuren BN, Overmars FJ, Ippel JH, Altona C, Wijmenga SS J Mol Biol. 2000 Dec 1;304(3):371-83. PMID:11090280<ref>PMID:11090280</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ezn" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Altona C]]
[[Category: Ippel JH]]
[[Category: Overmars FJ]]
[[Category: Wijmenga SS]]
[[Category: Van Buuren BNM]]