View source for 2mxz


==Bacteriophage T5 l-alanoyl-d-glutamate peptidase comlpex with Zn2+ (Endo T5-ZN2+)==
<StructureSection load='2mxz' size='340' side='right'caption='[[2mxz]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2mxz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T5 Escherichia virus T5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MXZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxz OCA], [https://pdbe.org/2mxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mxz RCSB], [https://www.ebi.ac.uk/pdbsum/2mxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT5 ENLYS_BPT5] Endolysin with L-alanyl-D-glutamate peptidase activity that degrades host peptidoglycans and participates with the holin in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer by hydrolyzing the link between L-alanine and D-glutamate residues.<ref>PMID:19919545</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia virus T5]]
[[Category: Large Structures]]
[[Category: Kutyshenko VP]]
[[Category: Mikoulinskaia GV]]
[[Category: Prokhorov DA]]