View source for 2wfo


==Crystal structure of Machupo virus envelope glycoprotein GP1==
<StructureSection load='2wfo' size='340' side='right'caption='[[2wfo]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2wfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Machu Machu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfo OCA], [https://pdbe.org/2wfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfo RCSB], [https://www.ebi.ac.uk/pdbsum/2wfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfo ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wfo ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
New World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor. This first structure of an arenavirus glycoprotein shows that GP1 consists of a novel alpha/beta fold. This provides a blueprint of the New World arenavirus attachment glycoproteins and reveals a new architecture of viral attachment, using a protein fold of unknown origins.

Unusual molecular architecture of the machupo virus attachment glycoprotein.,Bowden TA, Crispin M, Graham SC, Harvey DJ, Grimes JM, Jones EY, Stuart DI J Virol. 2009 Aug;83(16):8259-65. Epub 2009 Jun 3. PMID:19494008<ref>PMID:19494008</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2wfo" style="background-color:#fffaf0;"></div>

==See Also==
*[[Glycoprotein GP 3D structures|Glycoprotein GP 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Machu]]
[[Category: Bowden, T A]]
[[Category: Crispin, M]]
[[Category: Graham, S C]]
[[Category: Grimes, J M]]
[[Category: Harvey, D J]]
[[Category: Jones, E Y]]
[[Category: Stuart, D I]]
[[Category: Arenavirus]]
[[Category: Chapare]]
[[Category: Envelope protein]]
[[Category: Glycoprotein]]
[[Category: Gp1]]
[[Category: Guanarito]]
[[Category: Hemorrhagic fever virus]]
[[Category: Junin]]
[[Category: Machupo]]
[[Category: Macv]]
[[Category: New world arenavirus]]
[[Category: Sabia]]
[[Category: Transferrin receptor]]
[[Category: Viral attachment]]
[[Category: Viral protein]]
[[Category: Virion]]