View source for 2zaj


==Solution structure of the short-isoform of the second WW domain from the human membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI-1)==
<StructureSection load='2zaj' size='340' side='right'caption='[[2zaj]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2zaj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZAJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zaj OCA], [https://pdbe.org/2zaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zaj RCSB], [https://www.ebi.ac.uk/pdbsum/2zaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zaj ProSAT], [https://www.topsan.org/Proteins/RSGI/2zaj TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/za/2zaj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zaj ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Harada T]]
[[Category: Kigawa T]]
[[Category: Koshiba S]]
[[Category: Ohnishi S]]
[[Category: Tochio N]]
[[Category: Tomizawa T]]
[[Category: Watanabe S]]
[[Category: Yokoyama S]]