View source for 3zxb


==Wild type single insulin-like growth factor binding domain protein (SIBD-1) from Cupiennius salei==
<StructureSection load='3zxb' size='340' side='right'caption='[[3zxb]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3zxb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cupiennius_salei Cupiennius salei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZXB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxb OCA], [https://pdbe.org/3zxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zxb RCSB], [https://www.ebi.ac.uk/pdbsum/3zxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zxb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SIBD1_CUPSA SIBD1_CUPSA] Has a role in the innate immune system.<ref>PMID:21888974</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Cupiennius salei single insulin-like growth factor binding domain protein (SIBD-1) is an 8.6 kDa Cys-, Pro-, and Gly-rich protein, discovered in the hemocytes of the Central American hunting spider Cupiennius salei. SIBD-1 exhibits high sequence similarity to the N-terminal domain of the insulin-like growth factor-binding protein superfamily and has been reported to play an important role in the spider's immune system. Here, the recombinant expression as well as the elucidation of the three dimensional structure of recombinant SIBD-1 and the characterization of the sugar moiety at Thr2 of native SIBD-1 is described in detail. Proteins 2012. (c) 2012 Wiley-Liss, Inc.

Structural and Biochemical Characterization of Native and Recombinant Single Insulin-like Growth Factor-Binding Domain Protein (SIBD-1) from the Central American Hunting Spider Cupiennius salei (Ctenidae).,Trachsel C, Widmer C, Kampfer U, Buhr C, Baumann T, Kuhn-Nentwig L, Schurch S, Schaller J, Baumann U Proteins. 2012 May 24. doi: 10.1002/prot.24119. PMID:22622866<ref>PMID:22622866</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zxb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Cupiennius salei]]
[[Category: Large Structures]]
[[Category: Baumann U]]
[[Category: Widmer C]]