View source for 4ml0


==Crystal structure of E.coli DinJ-YafQ complex==
<StructureSection load='4ml0' size='340' side='right'caption='[[4ml0]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ml0]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B_str._REL606 Escherichia coli B str. REL606]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ML0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ML0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ml0 OCA], [https://pdbe.org/4ml0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ml0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ml0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ml0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DINJ_ECOBD DINJ_ECOBD] Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:24923448). A labile antitoxin that counteracts the effect of cognate toxin YafQ (PubMed:24923448). The YafQ-DinJ heterotetramer binds the consensus sequence 5'-TTTGAGCTACA-3' in the dinJ promoter; DinJ also binds DNA but not as well as the YafQ-DinJ complex (PubMed:24923448). Binding to the dinJ represses expression of the promoter (By similarity).[UniProtKB:Q47150]<ref>PMID:24923448</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli B str. REL606]]
[[Category: Large Structures]]
[[Category: Dong YH]]
[[Category: Gao ZQ]]
[[Category: Liang YJ]]
[[Category: Liu QS]]