View source for 5btb


==Crystal Structure of Ashbya gossypii Rai1==
<StructureSection load='5btb' size='340' side='right'caption='[[5btb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5btb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Eremothecium_gossypii_ATCC_10895 Eremothecium gossypii ATCC 10895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BTB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5btb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5btb OCA], [https://pdbe.org/5btb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5btb RCSB], [https://www.ebi.ac.uk/pdbsum/5btb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5btb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DXO_ASHGO DXO_ASHGO] Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (By similarity). In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (PubMed:26101253). Specifically degrades pre-mRNAs with a defective m7G cap and is part of a pre-mRNA capping quality control (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also has 5'-3' exonuclease activity (PubMed:26101253). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:26101253).[UniProtKB:O13836][UniProtKB:O70348][UniProtKB:Q06349]<ref>PMID:26101253</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Eremothecium gossypii ATCC 10895]]
[[Category: Large Structures]]
[[Category: Tong L]]
[[Category: Wang VY]]