View source for 5fsb


==Structure of tectonin 2 from laccaria bicolor in complex with 2-o-methyl-methyl-seleno-beta-l-fucopyranoside==
<StructureSection load='5fsb' size='340' side='right'caption='[[5fsb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5fsb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Laccaria_bicolor_S238N-H82 Laccaria bicolor S238N-H82]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FSB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6YR:2-O-METHYL-METHYL-SELENO-L-FUCOPYRANOSIDE'>6YR</scene>, <scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsb OCA], [https://pdbe.org/5fsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fsb RCSB], [https://www.ebi.ac.uk/pdbsum/5fsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B0CZL6_LACBS B0CZL6_LACBS] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Innate immunity is the first line of defense against pathogens and predators. To initiate a response, it relies on the detection of invaders, where lectin-carbohydrate interactions play a major role. O-Methylated glycans were previously identified as non-self epitopes and conserved targets for defense effector proteins belonging to the tectonin superfamily. Here, we present two crystal structures of Tectonin 2 from the mushroom Laccaria bicolor in complex with methylated ligands, unraveling the molecular basis for this original specificity. Furthermore, they revealed the formation of a ball-shaped tetramer with 24 binding sites distributed at its surface, resembling a small virus capsid. Based on the crystal structures, a methylation recognition motif was identified and found in the sequence of many tectonins from bacteria to human. Our results support a key role of tectonins in innate defense based on a distinctive and conserved type of lectin-glycan interaction.

Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.,Sommer R, Makshakova ON, Wohlschlager T, Hutin S, Marsh M, Titz A, Kunzler M, Varrot A Structure. 2018 Mar 6;26(3):391-402.e4. doi: 10.1016/j.str.2018.01.003. Epub 2018, Feb 1. PMID:29398527<ref>PMID:29398527</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5fsb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Laccaria bicolor S238N-H82]]
[[Category: Large Structures]]
[[Category: Bleuer S]]
[[Category: Kunzler M]]
[[Category: Sommer R]]
[[Category: Titz A]]
[[Category: Varrot A]]