View source for 6jcq


==AAV1 in complex with AAVR==
<SX load='6jcq' size='340' side='right' viewer='molstar' caption='[[6jcq]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6jcq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_-_1 Adeno-associated virus - 1] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JCQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jcq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcq OCA], [https://pdbe.org/6jcq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jcq RCSB], [https://www.ebi.ac.uk/pdbsum/6jcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9WBP8_9VIRU Q9WBP8_9VIRU] 
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== Publication Abstract from PubMed ==
Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.

Divergent engagements between adeno-associated viruses with their cellular receptor AAVR.,Zhang R, Xu G, Cao L, Sun Z, He Y, Cui M, Sun Y, Li S, Li H, Qin L, Hu M, Yuan Z, Rao Z, Ding W, Rao Z, Lou Z Nat Commun. 2019 Aug 21;10(1):3760. doi: 10.1038/s41467-019-11668-x. PMID:31434885<ref>PMID:31434885</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6jcq" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
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</SX>
[[Category: Adeno-associated virus - 1]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Lou Z]]
[[Category: Zhang R]]