View source for 8uoi


==Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #65==
<StructureSection load='8uoi' size='340' side='right'caption='[[8uoi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8uoi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UOI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X3Q:7-imidazo[1,2-b]pyridazin-3-yl-1-[(1~{R})-1-phenylethyl]-3-piperazin-1-yl-pyrido[3,4-b]pyrazin-2-one'>X3Q</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uoi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uoi OCA], [https://pdbe.org/8uoi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uoi RCSB], [https://www.ebi.ac.uk/pdbsum/8uoi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uoi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MARK3_HUMAN MARK3_HUMAN] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.<ref>PMID:16980613</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abendroth J]]
[[Category: Delker SL]]