View source for 8vg3


==Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure==
<StructureSection load='8vg3' size='340' side='right'caption='[[8vg3]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8vg3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VG3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vg3 OCA], [https://pdbe.org/8vg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vg3 RCSB], [https://www.ebi.ac.uk/pdbsum/8vg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vg3 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/ZN711_HUMAN ZN711_HUMAN] X-linked non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/ZN711_HUMAN ZN711_HUMAN] Transcription regulator required for brain development (PubMed:20346720). Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activated expression of genes involved in neuron development, such as KDM5C (PubMed:20346720, PubMed:31691806). May compete with transcription factor ARX for activation of expression of KDM5C (PubMed:31691806).<ref>PMID:20346720</ref> <ref>PMID:31691806</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Alexandrescu AT]]
[[Category: Rua AJ]]