View source for 9hvd


==Native human P-eIF2-eIF2B complex==
<StructureSection load='9hvd' size='340' side='right'caption='[[9hvd]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9hvd]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9HVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9HVD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9hvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9hvd OCA], [https://pdbe.org/9hvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9hvd RCSB], [https://www.ebi.ac.uk/pdbsum/9hvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9hvd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/EI2BG_HUMAN EI2BG_HUMAN] Juvenile or adult CACH syndrome;Congenital or early infantile CACH syndrome;Cree leukoencephalopathy;Late infantile CACH syndrome;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/EI2BG_HUMAN EI2BG_HUMAN] Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bertolotti A]]
[[Category: De Miguel C]]
[[Category: Thorkelsson SR]]
[[Category: Wang C]]